Evaluation of a ferret-specific formula for determining body surface area to improve chemotherapeutic dosing

Abstract

CT-derived BSA measurements of ferrets obtained via open-source imaging software were reliable. On the basis of study results, the recommended formula for BSA in ferrets would be 9.94 × (body weight)(2/3); however, this represented a relatively minor difference from the feline-derived formula currently used by most practitioners and would result in little practical change in drug doses.

Nota técnica: El área corporal en bovino de engorde está más correlacionada con la longitud corporal que con el peso corporal

“…Tradicionalmente, la BSA ha sido evaluada midiendo físicamente la superficie (por ejemplo, a partir de muestras de piel, por triangulación, usando un rodillo, utilizando moldes sobre cadáver…) (Elting, 1926;Jones et al, 2015;Kasabova y Holliday, 2015;Itoh et al, 2016). Más recientemente, se ha recurrido a la tomografía computerizada, que permite establecer la BSA de manera no invasiva (Jones et al, 2015). Nuestro método está basado en la obtención directa por fotogrametría -y por tanto se espera que muy ajustado a lo real- (Gaudioso et al, 2014).…”

“…El cálculo del área corporal ("Body Surface Area", BSA) es necesario para estudios de adaptación climática (Daniell et al, 2012;Kasabova y Holliday, 2015), farmacológicos (Daniell et al, 2012;Jones et al, 2015;Itoh et al, 2016), metabólicos (Elting, 1926;Berman, 2003;Daniell et al, 2012), de nutrición (Hogan y Skouby, 1923), para la evaluación de quemaduras (Daniell et al, 2012), en veterinaria forense (Henríquez et al, 2013), etc.…”

“…La primera ecuación desarrollada para estimar la BSA fue la de Meeh en 1879 (Hogan y Skouby, 1923;Daniell et al, 2012), que incluía el peso vivo, PV, como predictor, y que estaba basada en la proposición euclidiana de que para cuerpos de similar forma, el área de la superficie es proporcional a dos tercios de su volumen (Elting, 1926;Berman, 2003). En la estimación de Meeh, BSA (cm 2 ) = K × (PV en kg) 2/3 , donde K es una constante de la forma, cuyo valor difiere entre especies (Jones et al, 2015). Así, la BSA en perros se ha establecido como BSA = 10,1 × PV 2/3 , y para gatos BSA = 10 × PV 2/3 (Aiello et al, 2016).…”

Use of computed tomography and radiation therapy planning software to develop a novel formula for body surface area calculation in dogs

“…In that study, CT images from 12 pet rabbits were transferred to radiation therapy planning software and 1 mm slices were used to generate the surface contours to determine BSA, and nonlinear regression was then used in the current formula to generate a K constant of 9.9 . This was similar to another CT‐based derivation of a BSA formula for ferrets which yielded a K constant of 9.94 with the help of 3D surface modeling using open‐source imaging software to determine BSA . These values are similar to the K constant of 10 used in cats and 10.1 used in dogs .…”

Introductory Chapter - Morphometric Studies: Beyond Pure Anatomical Form Analysis

“…Similarly in animals, initial BSA data were obtained by pasting strips of strong manila paper, gummed on one side, to the hair of the animals [6] or rolling a revolving metal cylinder of a known area, attached to a revolution counter [7]. Recently, however, complex techniques, such as computed tomography have been applied [8], and these have undoubtedly improved the quality (precision, ease) of data (and, frankly, I cannot imagine a live ferret being wrapped in a sheet of paper to estimate its BSA! ).…”