Evaluation of a computer-based adverse-drug-event monitor

Abstract

The computer-based ADE monitor successfully identified most of the ADEs and almost all of the severe ADEs that occurred in the hospitalized patients. However, the accuracy of the computer-based ADE monitor needs to be improved.

Adverse drug events in hospitals: a systematic review

“…Twenty-eight articles remained 6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33 for evaluation, plus one more article retrieved by manual search 34 . Table 1 describes the studies, conducted in 13 countries from North America, Europe, South America, and Asia.…”

“…Most of the studies were performed in one hospital (19/29) 7,8,12,13,15,16,17,18,19,20,21,25,26,27,28,31,32,33,34 . Six were multi-center 6,9,22,23,24,29 and Figure 1 Flowchart of systematic article search and selection on in-hospital adverse drug events.…”

“…Interestingly, 62.1% of the studies (18/29) 6,7,8,9,12,13,15,16,19,20,21,22,25,26,27,31,33,34 involved university, academic, or teaching hospitals, i.e., presumably large-scale, high-complexity hospital units.…”

“…Only 41.4% (12/29) 6,7,10,11,12,20,21,26,27,28,29,33 provided information about age, and 24.1% (7/29) 6,7,10,20,26,27,33 on gender. As for the unit of analysis, 62.1% (18/29) 6,7,10,11,12,15,18,20,21,24,25,26,27,30,31,32,33,34 used the number of patients or patient charts, 48.3% (14/29) 6,8,9,12,14,16,17,20,22,23,25,28,29,33 the number of admissions or discharges, and 24.1% (7/29) 13,16,17,19,31,…”

“…The most widely used techniques included monitoring with screening criteria, review of patient charts, and use of the International Classification of Diseases (ICD) associated with ADEs. Monitoring with screening criteria related to the events was performed by 34.5% of the studies (10/29) 7,9,13,15,18,19,22,26,28,31 , either alone (3/29) 18,22,28 or in association (7/29) 7,9,13,15,19,26,31 . The filters consisted basically of rescue drugs, altered laboratory findings, or signs and symptoms related to adverse events.…”