Evaluation of 5-fluorouracil released from a foldable capsular vitreous body in vitro and in vivo

Zheng, Hao; Wang, Zhimin; Wang, Peijuan; Liu, Yaqin; Jiang, Zhaoxin; Gao, Qianying

doi:10.1007/s00417-011-1862-y

Cited by 17 publications

(15 citation statements)

References 28 publications

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“…In the FCVB capsule, mini-apertures of 300 nm were detected via the scanning electron microscope1755 and in our previous studies, we noted that these mini-apertures can slowly release micromolecular substances, such as dexamethasone sodium phosphate56, 5-fluorouracil (5-Fu)57 and siRNA-PKCα55. Therefore, the thin capsule membrane was highly oxygen permeable due to the mini-apertures.…”

Section: Discussionmentioning

confidence: 96%

Preliminary Study on Retinal Vascular and Oxygen-related Changes after Long-term Silicone Oil and Foldable Capsular Vitreous Body Tamponade

Yang

Yuan

Zong

et al. 2014

Sci Rep

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Silicone oil has been the only long-term vitreous substitute used in the treatment of retinal detachment since 1962 by Cibis. Nevertheless, its effects on retinal vascular morphology and oxygen supply to the retina are ambiguous in current research. We previously invented a foldable capsular vitreous body (FCVB) to use as a new vitreous substitute in the treatment of severe retinal detachment, but its effects on the retinal vessel were unknown. Therefore, in this study, a standard three-port pars plana vitrectomy (PPV) was performed on the right eye of each rabbit and then silicone oil and FCVB were injected into the vitreous cavity as vitreous substitutes. After 180 days of retention, the retinal vascular morphology did not display any distinct abnormalities, and hypoxia-induced factor-1alpha (HIF-1α) and vascular endothelial growth factor (VEGF) did not vary markedly during the observation period in silicone oil tamponade- and FCVB-implanted eyes. This study may suggest that silicone oil and FCVB tamponade in rabbit eyes did not cause retinal vascular pathologic changes or retinal hypoxia for 180 days.

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Section: Discussionmentioning

confidence: 96%

Preliminary Study on Retinal Vascular and Oxygen-related Changes after Long-term Silicone Oil and Foldable Capsular Vitreous Body Tamponade

Yang

Yuan

Zong

et al. 2014

Sci Rep

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“…Beyond that, since there are numerous 300 nm tiny apertures designed on the surface of the capsule, the FCVB can act as an intravitreal drug delivery system (DDS), and release drugs following associated pharmacokinetics synchronously. Plus, FCVB will not change the chemical property of drugs [34,[36][37][38]. For instance, the implanted FCVB can sustainably and mechanically release dexamethasone sodium phosphate (the molecular mass = 516.41 Da) through the apertures in a time-dependent and a dose-dependent manner [22].…”

Section: Discussionmentioning

confidence: 99%

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Zhang

Tian²,

Zhang³

et al. 2019

BMC Ophthalmol

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Background: Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1-year follow-up. Methods: A retrospective analysis was conducted for 20 patients with severe ocular trauma or silicone oil (SO) dependent eyes underwent vitrectomy and FCVB implantation in a 1-year follow-up. All treated eyes were peformed clinical examinations involved the visual acuity (VA) examination, Goldmann applanation tonometer, noncontact specular microscopy, fundus photography, B-Scan examination and optical coherence tomography (OCT). The groups were compared with t-test and the McNemar-Bowker test. Results: In 1-year follow-up, 20 eyes were evaluated in the study. FCVB well supported the vitreous retina in all treated eyes, and 6 treated eyes achieved retinal reattachment 12 months after FCVB implantation. There were no significant differences in VA before and after FCVB implantation (P = 1.000). In addition, the postoperative IOP markedly elevated from the preoperative IOP of 12.90 ± 7.06 mmHg to 15.15 ± 3.36 mmHg (P = 0.000017). The intraocular pressure (IOP) of 10 eyes maintained at a normal level after surgeries. The other 10 eyes showed slightly lower IOP within the acceptable level. Though two patients developed keratopathy and ocular inflammation respectively, other treated eyes were symmetric with fellow eyes showing satisfactory appearance. Moreover, there was no SO emulsification or leakage happened in the observation. Conclusions: FCVB implantation was an effective and safe treatment in the eyes with severe retinal detachment.

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“…PVP, PAA) tamponade. Moreover, many nanometer-wide apertures exist in the FCVB, and drugs can be released from the FCVB3637383940, so a drug may be added to the hydrogels, providing clinicians with a slow-release drug device. Therefore, this novel approach may develop into a new ideal vitreous substitute and open new options for the prevention and treatment of vitreous retinal diseases.…”

Section: Discussionmentioning

confidence: 99%

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

Feng

Chen

Liu

et al. 2013

Sci Rep

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Hydrogels may be the ideal vitreous substitutes due to their wonderful physical features and biocompatibility. However, their drawbacks, short residence time, and biodegradation in vivo, have led to the fact that none of them have been approved for clinical use. In this study, we developed a novel approach of using a foldable capsular vitreous body (FCVB) injected with polyvinylalcohol (PVA) hydrogel as a vitreous substitute for long-term tamponade. The 3% PVA hydrogel that was cross-linked by gamma irradiation showed good rheological and physical properties and had no toxicity in vitro. After 180 days retention, the 3% PVA hydrogel inside FCVB remained transparent and showed good viscoelasticity without biodegradation and showed good biocompatibility and retina support. This new approach may develop into a valuable tool to improve the stability performance of PVA hydrogel as a vitreous substitute and to extend the application function of FCVB for long-term implantation in vitreous cavity.

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Evaluation of 5-fluorouracil released from a foldable capsular vitreous body in vitro and in vivo

Cited by 17 publications

References 28 publications

Preliminary Study on Retinal Vascular and Oxygen-related Changes after Long-term Silicone Oil and Foldable Capsular Vitreous Body Tamponade

Preliminary Study on Retinal Vascular and Oxygen-related Changes after Long-term Silicone Oil and Foldable Capsular Vitreous Body Tamponade

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

A Novel Vitreous Substitute of Using a Foldable Capsular Vitreous Body Injected with Polyvinylalcohol Hydrogel

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