Preliminary Study on Retinal Vascular and Oxygen-related Changes after Long-term Silicone Oil and Foldable Capsular Vitreous Body Tamponade

Yang, Wei; Yuan, Yongguang; Zong, Yao; Huang, Zhen; Mai, Shuyi; Li, Yujie; Qian, Xiaobing; Liu, Yaqin; Gao, Qianying

doi:10.1038/srep05272

Cited by 24 publications

(19 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This indicated that silicone oil had no effect on the retinal vasculature when used for <6 months, suggesting that it has no significant toxic effect on the retinal vasculature. Furthermore, the present results were consistent with those of Yang et al (17), which demonstrated that SOT in rabbit eyes may not cause any pathological changes in the retinal vascular or retinal hypoxia over a period of 6 months.…”

Section: Discussionsupporting

confidence: 93%

Effect of silicone oil on macular capillary vessel density and thickness

et al. 2019

View full text Add to dashboard Cite

The present study assessed changes in macular capillary vessel density and thickness associated with ocular silicone oil tamponade (SOT) following complex vitreoretinal surgery. A total of 23 patients who underwent pars plana vitrectomy combined with intravitreal SOT were retrospectively enrolled, and a single eye was assessed in each participant. Furthermore, 20 patients who required silicone oil removal (SOR) were included. The macular capillary vessel density and the foveal avascular zone (FAZ) area were analyzed using optical coherence tomography angiography (OCTA) and retinal thickness was assessed by OCT. The results demonstrated that the macular capillary vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP), the FAZ area and full retinal thickness were retained at a stable level following SOT (P>0.05), and also following SOR (P>0.05). Furthermore, the parafoveal (P=0.008), superior-hemi (P=0.007), temporal (P=0.015), superior (P=0.028) and nasal (P=0.002) inner retinal thickness decreased in the SOT group, whereas the inner retinal thickness was unaltered after SOR vs. baseline (P>0.05). In conclusion, silicone oil has no significant effect on macular capillary vessel density within a 6-month period but may compress and reduce the thickness of the inner retina.

show abstract

Section: Discussionsupporting

confidence: 93%

Effect of silicone oil on macular capillary vessel density and thickness

et al. 2019

View full text Add to dashboard Cite

show abstract

“…It is therefore clear that the direct physical effect of silicone oil on retinal saturation is negligible. This conclusion is coincident with that of another study, which demonstrated that, after silicone oil tamponade for 6 months, the retinal vascular morphology did not display any distinct abnormalities and the hypoxia-induced factor-1 alpha (HIF-1 α ) and vascular endothelial growth factor (VEGF) concentrations did not vary markedly [ 23 ]. In addition, the partially recovered AVD after silicone oil removal may indicate the partial reversibility of the retinal pathological changes due to the silicone oil if the silicone oil is removed in time.…”

Section: Discussionsupporting

confidence: 86%

The Changes of Retinal Saturation after Long-Term Tamponade with Silicone Oil

Lou

Yuan

et al. 2015

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Purpose. To evaluate the effects of long-term tamponade with silicone oil on retinal saturation. Methods. A total of 49 eyes that received tamponade with silicone oil were included. The patients were divided into 3 groups (3–6 months, 6–9 months, and >9 months) according to the duration of silicone oil tamponade. Retinal oximetry was performed using the Oxymap system before and 2 months after silicone oil removal. Results. The mean retinal oxygen saturation before silicone oil removal was 107% ± 12% in the arterioles and 60% ± 10% in the venules, with an overall arteriovenous difference (AVD) of 47% ± 14%. The AVD in the >9-month group was significantly higher than that in the 3–6-month group (54% ± 16% versus 44% ± 11%, P = 0.042). After silicone oil removal, the AVD in the >9-month group was significantly decreased (45% ± 9% versus 54% ± 16%, P = 0.009); additionally, the arterioles were significantly wider than before surgery (10.8 ± 0.7 pixels versus 10.4 ± 0.9 pixels, P = 0.015). Conclusions. The tamponade with silicone oil for more than 9 months will cause the alterations of retinal saturation and the narrowing of retinal arterioles, which may further interfere with the oxygen metabolism in the retina.

show abstract

“…Since 2008, there have been at least 20 publications on the FCVB, ranging from original design and in vitro mechanical testing to animal testing and human clinical trials. [124][125][126][127][128][129][130][131][132][133][134][135][136][137][138][139][140][141][142][143] While radically different from the natural vitreous humor as well as other hydrogel vitreous substitute designs, the FCVB has been shown to be a safe and effective vitreous substitute in humans over a 1-and 3-year observation period. With clinical trials currently underway in China, the FCVB is arguably closest to routine clinical use in humans compared to other experimental hydrogel vitreous substitutes.…”

Section: The Strive For Improved Vitreous Substitutes and Intraocularmentioning

confidence: 99%

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Tram

Maxwell

Swindle-Reilly

2020

Current Eye Research

View full text Add to dashboard Cite

Research on the vitreous humor and development of hydrogel vitreous substitutes have gained a rapid increase in interest within the past two decades. However, the properties of the vitreous humor and vitreous substitutes have yet to be consolidated. In this paper, the mechanical properties of the vitreous humor and hydrogel vitreous substitutes were systematically reviewed. The number of publications on the vitreous humor and vitreous substitutes over the years, as well as their respective testing conditions and testing techniques were analyzed. The mechanical properties of the human vitreous were found to be most similar to the vitreous of pigs and rabbits. The storage and loss moduli of the hydrogel vitreous substitutes developed were found to be orders of magnitude higher in comparison to the native human vitreous. However, the reported modulus for human vitreous, which was most commonly tested in vitro, has been hypothesized to be different in vivo. Future studies should focus on testing the mechanical properties of the vitreous in situ or in vivo. In addition to its mechanical properties, the vitreous humor has other biotransport mechanisms and biochemical functions that establish a redox balance and maintain an oxygen gradient inside the vitreous chamber to protect intraocular tissues from oxidative damage. Biomimetic hydrogel vitreous substitutes have the potential to provide ophthalmologists with additional avenues for treating and controlling vitreoretinal diseases while preventing complications after vitrectomy. Due to the proximity and interconnectedness of the vitreous humor to other ocular tissues, particularly the lens and the retina, more interest has been placed on understanding the properties of the vitreous humor in recent years. A better understanding of the properties of the vitreous humor will aid in improving the design of biomimetic vitreous substitutes and enhancing intravitreal biotransport.

show abstract

Preliminary Study on Retinal Vascular and Oxygen-related Changes after Long-term Silicone Oil and Foldable Capsular Vitreous Body Tamponade

Cited by 24 publications

References 51 publications

Effect of silicone oil on macular capillary vessel density and thickness

Effect of silicone oil on macular capillary vessel density and thickness

The Changes of Retinal Saturation after Long-Term Tamponade with Silicone Oil

Macro- and Microscale Properties of the Vitreous Humor to Inform Substitute Design and Intravitreal Biotransport

Contact Info

Product

Resources

About