Evaluation of 25‐hydroxy vitamin D levels and disease severity in patients with acne vulgaris

Abstract

Acne vulgaris is a multifactorial skin disorder. Many etiological factors are speculated to contribute to the pathogenesis of acne, one of these is vitamin D deficiency. Previous studies reported contradictory results about serum 25 hydroxy vitamin D (25‐OH vitamin D) levels, its association with acne, some claimed that acne lesion might improve with vitamin D supplementation. We aimed to assess serum 25‐OH vitamin D levels in acne patients, identify their relation with disease severity in a larger study group. The study included 134 acne patients, 129 controls. Acne disease severity was identified with Global Acne Grading Scale (GAGS) scores. Serum 25‐OH vitamin D levels were measured in all groups. Serum 25‐OH vitamin D levels were significantly lower in acne patients than in controls (P < .001). The prevalence of vitamin D deficiency was significantly higher in acne group than in control group (77.6% vs 63.9%; P = .041). There was a negative‐strong statistically significant correlation detected between serum 25‐OH vitamin D levels and GAGS scores in patient group (P < .001; r = −.910). According to these results, we claim that evaluating serum 25‐OH vitamin D levels in acne patients, vitamin D supplementation as a treatment option may be a consideration for further studies.

Association between Vitamin D Level and Acne, and Correlation with Disease Severity: A Meta-Analysis

“…Acne severity was identified in seven studies. Four studies [13, 16, 17, 21] demonstrated a statistically significant difference of serum 25(OH)D levels among patients with acne at varying severities. These studies showed an inverse association between acne severity and vitamin D level.…”

“…These studies showed an inverse association between acne severity and vitamin D level. Although the studies conducted by Lim et al [13] and Kemeriz et al [21] provided a correlation coefficient at –0.512 and –0.91, respectively, a meta-analysis could not be evaluated due to the different parameters. Nevertheless, both studies demonstrated that the higher the vitamin D deficiency, the more severe the acne.…”

“…Therefore, thirteen studies, involving 1,362 patients with acne and 1,081 HCs, were finally included. The characteristics of the thirteen studies [6,[10][11][12][13][14][15][16][17][18][19][20][21] are presented in Table 1.…”

Serum 25-Hydroxy Vitamin D Level Does Not Reflect The Severity of Wart: A Cross-Sectional Study

“…The relationship between skin diseases and serum 25-OH vit D levels has become a topic of interest and research in recent years. Psoriasis, atopic dermatitis, vitiligo, alopecia areata, mycosis fungoides, systemic lupus erythematosus, systemic sclerosis and acne are skin diseases associated with low serum vitamin D levels (16)(17)(18)(19)(20)(21)(22)(23)(24). To the best of our knowledge, the relationship between verruca vulgaris and serum 25-OH vit D has only been investigated in two studies, and the results of these two studies are opposite (10,11).…”

Der Einfluss der Ernährung bei entzündlichen Gesichtsdermatosen

“…Mangelzustände von Vitaminen und Spurenelementen sollten ausgeglichen werden. Studien haben gezeigt, dass Aknepatienten einen signifikanten Mangel an Vitamin D und Zink im Vergleich zu hautgesunden Kontrollgruppen aufweisen können [64]. Eine Metaanalyse zeigte eine interessante inverse Beziehung zwischen dem Vitamin‐D‐Spiegel von Patienten und dem klinischen Schweregrad einer Akne.…”