Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns

Urbancová, Kateřina; Lanková, Darina; Rössner, Pavel; Rössnerová, Andrea; Švecová, Vlasta; Tomaniová, Monika; Velemínský, Miloš; Šrám, Radìm J.; Hajšlová, Jana; Pulkrabová, Jana

doi:10.1016/j.scitotenv.2016.10.165

Cited by 55 publications

(35 citation statements)

References 39 publications

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“…35, 42–46 Urinary PAH metabolites reflect the internal dose from all recent exposure sources. Other studies of PAH exposure in pregnancy have examined PAH adducts in placenta, 47 indicative of the biologically effective dose in that tissue.…”

Section: Discussionmentioning

confidence: 99%

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Ferguson

McElrath

Pace

et al. 2017

Environ. Sci. Technol.

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Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) is prevalent and may adversely impact pregnancy and development of the fetus. The purpose of this exploratory study was to examine urinary PAH metabolites in association with mediators of these outcomes. To do so we measured a panel of 12 inflammatory, angiogenic, and oxidative stress biomarkers in plasma or urine from women in their third trimester of pregnancy (n=200). Urinary PAH metabolites were highly detectable (>88%) in the study population, and most were higher in women who had lower education levels, higher body mass index, and who were African American. Some PAH metabolites showed consistent positive associations with the plasma inflammation marker C-reactive protein (CRP) and the urinary oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. For example, an interquartile range increase in 2-hydroxynapthalene was associated with a 35% increase in CRP (95% confidence interval = −0.13, 83.2), a 14% increase in 8-OHdG (95% confidence interval = 0.59, 30.1), and a 48% increase in 8-isoprostane (95% confidence interval = 16.7, 87.0). These data suggest that exposure to PAHs may cause systemic changes during pregnancy that could lead to adverse pregnancy or developmental outcomes; however, these results should be corroborated in a larger study population.

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Section: Discussionmentioning

confidence: 99%

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Ferguson

McElrath

Pace

et al. 2017

Environ. Sci. Technol.

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“…The values of 2‐OH‐Phe and 3‐OH‐Phe are in between them. Urbancova documented another order with 3‐OH‐PAH having the lowest mean, followed by 2‐OH‐Phe, 4‐OH‐Phe, 9‐OH‐Phe and 1‐OH‐Phe (Urbancova et al, ). The (geometric) mean for 1‐OH‐Pyr is mostly in the range of the values for 2‐ or 3‐OH‐Phe for all studies.…”

Section: Resultsmentioning

confidence: 99%

“…The mean values in our study are lower, ranging from 0.066 μg/g creatinine for 4‐OH‐Phe to 0.304 μg/g creatinine for 1‐OH‐Phe. The group of Urbancova et al () recently analyzed 531 urine samples of newborns and their mothers in the Czech Republic. They documented mean values between 0.098 μg/g creatinine for 3‐OH‐Phe and 0.540 μg/g creatinine for 1‐OH‐Phen.…”

Section: Resultsmentioning

confidence: 99%

“…Li et al, ; Li et al, ; Lin et al, ; Motorykin, Santiago‐Delgado et al, ; Nilsson et al, ; Polanska et al, ). Simultaneously, the number of quantifiable OH‐PAH has increased, and it differs depending on the analytical method applied and the study performed (Lankova, Urbancova, Sram, Hajslova, & Pulkrabova, ; Li et al, ; Polanska et al, ; Urbancova et al, ). Monohydroxylated PAH are not only formed in mammalian organisms but can also be generated by combustion of organic materials and during transformation processes of PAH in ambient air (Avagyan, Nyström, Lindgren, Boman, & Westerholm, ; Keyte, Harrison, & Lammel, ; Lin et al, ; Ma et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Detection of monohydroxylated polycyclic aromatic hydrocarbons in urine and particulate matter using LC separations coupled with integrated SPE and fluorescence detection or coupled with high‐resolution time‐of‐flight mass spectrometry

Lintelmann

Kuhn

et al. 2018

Biomedical Chromatography

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A high-performance liquid chromatographic (HPLC) method with integrated solid-phase extraction for the determination of 1-hydroxypyrene and 1-, 2-, 3-, 4- and 9-hydroxyphenanthrene in urine was developed and validated. After enzymatic treatment and centrifugation of 500 μL urine, 100 μL of the sample was directly injected into the HPLC system. Integrated solid-phase extraction was performed on a selective, copper phthalocyanine modified packing material. Subsequent chromatographic separation was achieved on a pentafluorophenyl core-shell column using a methanol gradient. For quantification, time-programmed fluorescence detection was used. Matrix-dependent recoveries were between 94.8 and 102.4%, repeatability and reproducibility ranged from 2.2 to 17.9% and detection limits lay between 2.6 and 13.6 ng/L urine. A set of 16 samples from normally exposed adults was analyzed using this HPLC-fluorescence detection method. Results were comparable with those reported in other studies. The chromatographic separation of the method was transferred to an ultra-high-performance liquid chromatography pentafluorophenyl core-shell column and coupled to a high-resolution time-of-flight mass spectrometer (HR-TOF-MS). The resulting method was used to demonstrate the applicability of LC-HR-TOF-MS for simultaneous target and suspect screening of monohydroxylated polycyclic aromatic hydrocarbons in extracts of urine and particulate matter.

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“…For the urine of mothers and newborns, monohydroxylated metabolites of PAHs (OH-PAHs) were analyzed [41]. While the content of ΣOH-PAHs in mothers' urine collected in the summer period was comparable in both Karvina and Ceske Budejovice, in the winter period, the samples from the Karvina region showed 1.5 times higher amounts of exposure markers.…”

Section: Pah Metabolism In Urine Of Mothers and Newbornsmentioning

confidence: 99%

Influences the Aeromath in the Way of Ending Births

Šrám¹,

Velemínský²

2020

Childbirth

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Air pollution represents a significant health problem in the Czech Republic (CR). Originally, the most polluted region was Northern Bohemia, later Northern Moravia. These specific conditions were used to study the impact of air pollution to children in those two regions. In Northern Bohemia, the impact of the increased concentrations of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) to fetal growth was observed, expressed as intrauterine growth retardation and impact of air pollution to respiratory morbidity and neurodevelopment in children. In Northern Moravia was studied the effect of air pollution to the morbidity of preschool children; to asthma bronchiale-gene expression, children susceptibility to benzo[a]pyrene (B[a]P); to genetic damage in newborns; concentrations of PAHs in the urine of mothers and newborns, content of PAHs in human breast milk and diet.

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Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns

Cited by 55 publications

References 39 publications

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Detection of monohydroxylated polycyclic aromatic hydrocarbons in urine and particulate matter using LC separations coupled with integrated SPE and fluorescence detection or coupled with high‐resolution time‐of‐flight mass spectrometry

Influences the Aeromath in the Way of Ending Births

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