Evaluation gastric cancer incidence in Kazakhstan.

Igissinov, Nurbek; Kozhakhmetov, Saken; Malayev, N.B.; Taszhanov, R.S.; Bilyalova, Zarina; Igissinova, Gulnur; Beysebayev, Eldar; Moore, M. A. S.; Leja, M.

doi:10.31082/1728-452x-2018-195-9-30-36

Cited by 3 publications

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References 1 publication

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“…While the standardized incidence rate in women (10.7 0 / 0000 ) was three times less than in men (31.1 0 / 0000 ). In our previous studies, the same pattern was revealed (Igissinov et al, 2018). Especially pronounced decrease was in men aged 55-59 (R 2 =0.6589), and in women aged 60-64 (R 2 =0.7287).…”

Section: Discussionsupporting

confidence: 80%

Geographic Variability of Gastric Cancer Incidence in Kazakhstan

Taszhanov

Telmanova

Zhadykova

et al. 2022

Asian Pac J Cancer Prev

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Objective:The article studies the geographical features of the incidence of gastric cancer (GC) in Kazakhstan. Methods: The retrospective study was done for the period 2009-2018. Descriptive and analytical methods of oncoepidemiology were used. Crude (CR), age-specific (ASIR), age-standardized (ASR), equalized incidence rates and approximation were calculated. The dynamics of indicators was investigated using component analysis according to methodological recommendations. The method of drawing up a cartogram based on the determination of the standard deviation (σ) from the mean (x) was applied. Results: During the study period, 27,467 new cases of GC were registered. The incidence rate increased from 16.80 (2009) to 15.10 in 2018 and the overall decline was 1.70 per 100,000 population, including due to the age structure -∑Δ A =+1.51, due to the risk of acquiring illness -∑Δ R =−2.91 and their combined effect -∑Δ RA =−0.31. The component analysis revealed that the increase in the number of patients with GC was mainly due to the growth of the population (Δ P =+651.8%), changes in its age structure (Δ A =+433.9%) and changes associated with the risk of acquiring illness (Δ R =−832.1%). The cartograms were allocated according to the following criteria: low -up to 14.8 0 / 0000 , average -from 14.8 to 19.2 0 / 0000 , high -above 19.2 0 / 0000 . The results of the spatial assessment showed the highest levels of GC incidence in following regions: Akmola (22.2 0 / 0000 ), North Kazakhstan (22.3 0 / 0000 ), and Pavlodar (23.2 0 / 0000 ). Conclusion: Thus, as a result of the epidemiological analysis, the role of the influence of demographic factors and the risk of acquiring illness on the formation of the number of patients and the incidence of GC was evaluated, while sex differences and geographical variability were established.

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Section: Discussionsupporting

confidence: 80%

Geographic Variability of Gastric Cancer Incidence in Kazakhstan

Taszhanov

Telmanova

Zhadykova

et al. 2022

Asian Pac J Cancer Prev

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“…Helicobacter pylori (H. pylori) infection is still a significant public health problem worldwide (Hooi et al, 2017), and it is the major risk factor for the development of gastric cancer (Pereira-Marques et al, 2019;Wroblewski et al, 2010). Despite a decreasing trend in incidence rates during recent decades, it is still among the most common cancers and leading causes of cancer death globally (Igissinov et al, 2018). De Martel et al, (2020) reported that 810,000 new cases of gastric cancer (mainly non-cardia gastric adenocarcinoma) were attributed to chronic H. pylori infection in 2018.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Potential Risk Factors of Helicobacter pylori Infection among Asymptomatic Individuals in Kazakhstan

Mežmale

Poļaka

Rudzite

et al. 2021

Asian Pac J Cancer Prev

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“…However, recent data show that gastric cancer dynamics of incidence and mortality revealed a downward trend. It is not consistent with global statistics, where forecast indicators are rising (Igissinov et al, 2018;Igissinov et al, 2019).…”

Section: Introductionmentioning

confidence: 80%

Prevalence of Atrophic Gastritis in Kazakhstan and the Accuracy of Pepsinogen Tests to Detect Gastric Mucosal Atrophy

Mežmale¹,

Isajevs²,

Bogdanova³

et al. 2019

Asian Pac J Cancer Prev

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Background: Atrophic gastritis is considered precursor condition for gastric cancer. There is so far limited evidence on the performance of pepsinogens for atrophy detection in Central Asia. The aim of our study was to detect the prevalence of atrophic gastritis in the asymptomatic adult population in Kazakhstan as well as address the accuracy of pepsinogen testing in atrophy detection. Methods: Healthy individuals aged 40-64 were included. Upper endoscopy and pepsinogens (PG) evaluation were performed. PG were analysed in plasma by latex agglutination. Cut off values were used to define decreased PG values (PGR ≤ 3 and PG I ≤ 70 ng/mL); severely decreased PG values (PGR ≤ 2 and PG I ≤ 30 ng/mL). Biopsies were analyzed and obtained according to the updated Sydney System. PG test sensitivity, specificity and overall accuracy were assessed using the histological diagnosis as the "gold standard". Results: Altogether 157 individuals-female 40,1% and male 59,9% were included. Histologically, moderate to severe corpus atrophy, was present only in 1,3% cases. From all study subjects, 26,8% had decreased plasma PG values with cutoff values PGR ≤ 3 and PG I ≤ 70 ng/mL. The sensitivity of the PG test with this cutoff values was 50,0%, specificity 73,5%, overall accuracy 73,2% for detection of moderate to severe atrophy in the corpus. The sensitivity of PG test with cutoff values PGR ≤ 2 and PG I ≤30 ng/mL was 50,0%, specificity 90,9% and overall accuracy 90,4%. Conclusions: The prevalence of gastric mucosal atrophy was low in the Kazakh population. Serological PG test screening nevertheless can play an important role in the diagnosis of gastric precancerous lesions. However, the diagnostic accuracy of the PG test is mainly dependent on the cutoff values for positive results.

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Evaluation gastric cancer incidence in Kazakhstan.

Cited by 3 publications

References 1 publication

Geographic Variability of Gastric Cancer Incidence in Kazakhstan

Geographic Variability of Gastric Cancer Incidence in Kazakhstan

Prevalence and Potential Risk Factors of Helicobacter pylori Infection among Asymptomatic Individuals in Kazakhstan

Prevalence of Atrophic Gastritis in Kazakhstan and the Accuracy of Pepsinogen Tests to Detect Gastric Mucosal Atrophy

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