Évaluation du degré de malignité des tumeurs gliales primitives de l’adulte en IRM de perfusion par marquage des spins

Canale, Sandra; Rodrigo, S.; Tourdias, Thomas; Mellerio, Charles; Perrin, M.; Souillard, R.; Oppenheim, Catherine; Méder, Jean-François

doi:10.1016/j.neurad.2010.12.003

Cited by 9 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…All but two studies with negative results [9, 30] that applied PASL in gliomas showed its efficiency in differentiating between HGGs and LGGs [7, 20, 23–25, 31, 32] and in glioma grading [8]. All studies that utilised CASL in gliomas [21, 22, 30] were promising in differentiation between HGGs and LGGs. Nonetheless, recent studies drew conflicting conclusions regarding the usefulness of PCASL acquisitions as it helped to identify HGGs from LGGs [6] and to perform grading [5], whilst a couple of publications didn't confirm the findings [9–11].…”

Section: Discussionmentioning

confidence: 99%

“…Furtner et al identified the most effective TI for determining the HGGs from the LGGs astrocytomas at 370 ms [23]. Other studies employed variable single delay times within a range of 1200–1900 ms, and reported similar or lower sensitivity and specificity [6, 8, 20, 24, 30, 31]. Unlike using a single TI, the use of multiple TIs makes CBF quantification more reliable and less sensitive to bolus arrival time.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

et al. 2019

View full text Add to dashboard Cite

This study aimed to evaluate the diagnostic performance of arterial spin labelling (ASL) in grading of adult gliomas. Eighteen studies matched the inclusion criteria and were included after systematic searches through EMBASE and MEDLINE databases. The quality of the included studies was assessed utilizing Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). The quantitative values were extracted and a meta-analysis was subsequently based on a random-effect model with forest plot and joint sensitivity and specificity modelling. Hierarchical summary receiver operating characteristic (HROC) curve analysis was also conducted. The absolute tumour blood flow (TBF) values can differentiate high-grade gliomas (HGGs) from low-grade gliomas (LGGs) and grade II from grade IV tumours. However, it lacked the capacity to differentiate grade II from grade III tumours and grade III from grade IV tumours. In contrast, the relative TBF (rTBF) is effective in differentiating HGG from LGG and in glioma grading. The maximum rTBF (rTBFmax) demonstrated the best results in glioma grading. These results were also reflected in the sensitivity/specificity analysis in which the rTBFmax showed the highest discrimination performance in glioma grading. The estimated effect size for the rTBF was approximately similar between HGGs and LGGs, and grade II and grade III tumours, (–1.46 (–2.00, –0.91), p-value < 0.001), (–1.39 (–1.89, –0.89), p-value < 0.001), respectively; while it exhibited smaller effect size between grade III and grade IV (–1.05 (–1.82, –0.27)), p < 0.05). Sensitivity and specificity analysis replicate these results as well. This meta-analysis suggests that ASL is useful for glioma grading, especially when considering the rTBFmax parameter.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…MR perfusion has been used in a variety of clinical situations including evaluation of stroke[8], grading of gliomas[9, 10], and differentiation of benign and malignant meningiomas[11]. Dynamic susceptibility contrast (DSC) MR perfusion involves injection of gadolinium contrast and can provide quantitative information such as MTT, CBV, and CBF.…”

Section: Introductionmentioning

confidence: 99%

Intra-Arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subtraction Angiography and Intravenous MR Perfusion Imaging

et al. 2016

View full text Add to dashboard Cite

Background and PurposeTo evaluate the ability of IA MR perfusion to characterize meningioma blood supply.MethodsStudies were performed in a suite comprised of an x-ray angiography unit and 1.5T MR scanner that permitted intraprocedural patient movement between the imaging modalities. Patients underwent intra-arterial (IA) and intravenous (IV) T2* dynamic susceptibility MR perfusion immediately prior to meningioma embolization. Regional tumor arterial supply was characterized by digital subtraction angiography and classified as external carotid artery (ECA) dural, internal carotid artery (ICA) dural, or pial. MR perfusion data regions of interest (ROIs) were analyzed in regions with different vascular supply to extract peak height, full-width at half-maximum (FWHM), relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and mean transit time (MTT). Linear mixed modeling was used to identify perfusion curve parameter differences for each ROI for IA and IV MR imaging techniques. IA vs. IV perfusion parameters were also directly compared for each ROI using linear mixed modeling.Results18 ROIs were analyzed in 12 patients. Arterial supply was identified as ECA dural (n = 11), ICA dural (n = 4), or pial (n = 3). FWHM, rCBV, and rCBF showed statistically significant differences between ROIs for IA MR perfusion. Peak Height and FWHM showed statistically significant differences between ROIs for IV MR perfusion. RCBV and MTT were significantly lower for IA perfusion in the Dural ECA compared to IV perfusion. Relative CBF in IA MR was found to be significantly higher in the Dural ICA region and MTT significantly lower compared to IV perfusion.

show abstract

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

et al. 2014

View full text Add to dashboard Cite

Angiogenesis plays a major role in tumor growth and metastasis, with tumor perfusion regarded as a marker for angiogenesis. To evaluate antiangiogenic treatment response in vivo, we investigated arterial spin labeling (ASL) magnetic resonance imaging (MRI) to measure tumor perfusion quantitatively. Chronic and 24-h acute treatment responses to bevacizumab were assessed by ASL and dynamic-contrast-enhanced (DCE) MRI in the A498 xenograft mouse model. After the MRI, tumor vasculature was assessed by CD34 staining. After 39 days of chronic treatment, tumor perfusion decreased to 44.8 ± 16.1 mL/100 g/min (P < 0.05), compared to 92.6 ± 42.9 mL/100 g/min in the control group. In the acute treatment study, tumor perfusion in the treated group decreased from 107.2 ± 32.7 to 73.7 ± 27.8 mL/100 g/min (P < 0.01; two-way analysis of variance), as well as compared with control group post dosing. A significant reduction in vessel density and vessel size was observed after the chronic treatment, while only vessel size was reduced 24 h after acute treatment. The tumor perfusion correlated with vessel size (r = 0.66; P < 0.005) after chronic, but not after acute treatment. The results from DCE-MRI also detected a significant change between treated and control groups in both chronic and acute treatment studies, but not between 0 and 24 h in the acute treatment group. These results indicate that tumor perfusion measured by MRI can detect early vascular responses to antiangiogenic treatment. With its noninvasive and quantitative nature, ASL MRI would be valuable for longitudinal assessment of tumor perfusion and in translation from animal models to human.

show abstract

Évaluation du degré de malignité des tumeurs gliales primitives de l’adulte en IRM de perfusion par marquage des spins

Cited by 9 publications

References 30 publications

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

The value of arterial spin labelling in adults glioma grading: systematic review and meta-analysis

Intra-Arterial MR Perfusion Imaging of Meningiomas: Comparison to Digital Subtraction Angiography and Intravenous MR Perfusion Imaging

Early detection of antiangiogenic treatment responses in a mouse xenograft tumor model using quantitative perfusion MRI

Contact Info

Product

Resources

About