Evaluation de la plainte cognitive de patients Alzheimer, de sujets MCI, anxiodépressifs et de témoins avec le QPC (Questionnaire de Plainte Cognitive)

Thomas‐Antérion, Catherine; Ribas, Carmen Austrália Paredes Marcondes; Honore-Masson, S.; Million, J.; Laurent, Bernard

doi:10.1016/s1627-4830(04)97931-7

Cited by 21 publications

(13 citation statements)

References 10 publications

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“…Depression and anxiety were assessed using the Hospital Anxiety and Depression (HAD) scale [35]. A cognitive complaints questionnaire (Questionnaire de Plainte Cognitive (QPC) [36, 37]) was employed to evaluate participants’ memory failures and cognitive complaints.…”

Section: Methodsmentioning

confidence: 99%

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

et al. 2017

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BackgroundDuring adulthood, personality characteristics may contribute to the individual capacity to compensate the impact of developing cerebral Alzheimer’s disease (AD) pathology on cognitive impairment in later life. In this study we aimed to investigate whether and how premorbid personality traits interact with cerebrospinal fluid (CSF) markers of AD pathology to predict cognitive performance in subjects with mild cognitive impairment or mild AD dementia and in participants with normal cognition.MethodsOne hundred and ten subjects, of whom 66 were patients with mild cognitive impairment or mild AD dementia and 44 were healthy controls, had a comprehensive medical and neuropsychological examination as well as lumbar puncture to measure CSF biomarkers of AD pathology (amyloid beta1–42, phosphorylated tau and total-tau). Participants’ proxies completed the Revised NEO Personality Inventory, Form R to retrospectively assess subjects’ premorbid personality.ResultsIn hierarchical multivariate regression analyses, including age, gender, education, APOEε4 status and cognitive level, premorbid neuroticism, conscientiousness and agreeableness modulated the effect of CSF biomarkers on cognitive performance. Low premorbid openness independently predicted lower levels of cognitive functioning after controlling for biomarker concentrations.ConclusionOur findings suggest that specific premorbid personality traits are associated with cerebral AD pathology and modulate its impact on cognitive performance. Considering personality characteristics may help to appraise a person’s cognitive reserve and the risk of cognitive decline in later life.

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Section: Methodsmentioning

confidence: 99%

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

et al. 2017

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“…The sampling and data collection procedures have been described elsewhere [19]. In summary, subjective memory complaint was documented using the Subjective Memory Complaints Questionnaire [20] and the main exclusion criteria were age below 60 years, Mini‐Mental State Examination (MMSE) score <10 [21], inability to walk independently, history of stroke, occurrence of any acute medical illness within the past 3 months, current delirium, severe depression, and inability to understand or answer the study questionnaires. Recruitment in the GAIT study is still ongoing.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, mood was assessed with the 15‐item Geriatric Depression Scale (GDS) [25] whose score increases in the presence of depressive symptoms. The MMSE [20] and the Frontal Assessment Battery [26] scores were also used to assess, respectively, cognitive performance as a whole, and executive functions. Finally, the season of evaluation was noted as follows: spring from 21 March to 20 June; summer from 21 June to 20 September; autumn from 21 September to 20 December; and winter from 21 December to 20 March.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D insufficiency and mild cognitive impairment: cross‐sectional association

Annweiler

Fantino

Schott

et al. 2012

Euro J of Neurology

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“…Depression and anxiety were assessed using the Hospital Anxiety and Depression scale (HAD) (Zigmond and Snaith, 1983). Cognitive complaints questionnaire (Questionnaire de Plainte Cognitive, QPC, (Thomas-Antérion et al, 2004;Thomas-anterion et al, 2004)) was employed to evaluate participants' memory failures and cognitive complaints.…”

Section: Neuropsychological and Functional Assessmentmentioning

confidence: 99%

Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology

Tautvydaitė

Antonietti

Henry

et al. 2017

Journal of Psychiatric Research

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Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interaction between personality change, cognitive decline, and cerebral pathology. With this study we aimed to describe the relationship between personality changes and cerebrospinal fluid (CSF) markers of AD pathology at early clinical stages of the disease. One hundred and ten subjects, of whom 66 cognitively impaired patients (57 with mild cognitive impairment (MCI), and 9 with mild dementia) and 44 healthy controls, had neuropsychological examination as well as lumbar puncture to determine concentrations of CSF biomarkers of AD pathology (amyloid beta (Aβ), phosphorylated tau (ptau-181), and total-tau (tau)). The Revised NEO Personality Inventory (NEO-PI-R) was administered twice, once to evaluate subjects' current personality and once to assess personality traits retrospectively 5 years before evaluation. Subjects with an AD CSF biomarker profile showed significant increase in neuroticism and decrease in conscientiousness over time as compared to non-AD CSF biomarker group. In regression analysis controlling for global cognition as measured by the MMSE score, increasing neuroticism and decreasing extraversion, openness to experience and conscientiousness were associated with lower Aβ concentrations but not with tau and ptau-181 concentrations. Our findings suggest that early and specific changes in personality are associated with cerebral AD pathology. Concentrations of CSF biomarkers, additionally to severity of the cognitive impairment, significantly contribute in predicting specific personality changes.

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Evaluation de la plainte cognitive de patients Alzheimer, de sujets MCI, anxiodépressifs et de témoins avec le QPC (Questionnaire de Plainte Cognitive)

Cited by 21 publications

References 10 publications

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

Vitamin D insufficiency and mild cognitive impairment: cross‐sectional association

Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology

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