Vitamin D insufficiency and mild cognitive impairment: cross‐sectional association

Annweiler, Cédric; Fantino, Bruno; Schott, Anne-Marie; Krolak‐Salmon, Pierre; Allali, Gilles; Beauchet, Olivier

doi:10.1111/j.1468-1331.2012.03675.x

Cited by 76 publications

(60 citation statements)

References 39 publications

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“…Valuable, though limited in number, longitudinal studies indicated low levels of vitamin D were associated with substantial cognitive decline in the elderly population (Llewellyn et al 2010) and baseline vitamin D deficiency predicted the onset of non Alzheimer dementias (Annweiler et al 2012b). Importantly, Annweiler et al (2012a) showed the association of elevated serum 25OHD concentration with a lower risk of mild cognitive impairment (MCI) and the association of low 25OHD concentrations with MCI status in older non-demented people with subjective memory complaint, suggesting that hypovitaminosis D may participate in the dementia process from prodromal stages. Recent remarkable studies showed that vitamin D strongly stimulated phagocytosis and clearance of beta amyloid while protecting against apoptosis in AD patients' macrophages (Masoumi et al 2009;Mizwicki et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Gezen-Ak

Dursun

Bılgıç

et al. 2012

Tohoku J. Exp. Med.

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Vitamin D 3 is a neurosteroid that mediates its effects via the vitamin D receptor (VDR). The VDR gene is located on chromosome 12q13 and consists of 9 exons. VDR contains the DNA-binding site encoded by exons 2 and 3 and the ligand-binding site encoded by exons 4 -9. Our earlier study showed that the ApaI polymorphic site of the VDR gene is associated with late-onset Alzheimer's disease (AD). Here, we investigated the association between additional polymorphisms of the VDR gene and AD using the same samples. Two single nucleotide polymorphisms (SNPs) in intron 8 (BsmI and Tru9I polymorphisms) and one in exon 2 (FokI polymorphism) of the VDR gene were examined in up to 108 AD patients and 115 age-matched controls. Genotypes were determined with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Haplotype analysis also included the previously studied polymorphic sites that were recognized by TaqI (in exon 9) and ApaI (in intron 8) restriction enzymes. There was no significant difference between AD patients and controls when their genotypes for BsmI, Tru9I and FokI polymorphic sites were compared. However, the frequency of "TaubF" haplotype (alleles of TaqI, ApaI, Tru9I, BsmI and FokI, respectively), which was determined by analyzing 5 polymorphisms together, was significantly higher in the AD patient group, suggesting that this haplotype is a risk factor in AD. Our results point out a possible link between AD and certain VDR polymorphisms and indicate that individuals with these polymorphisms might be vulnerable to AD.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Gezen-Ak

Dursun

Bılgıç

et al. 2012

Tohoku J. Exp. Med.

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“…The GAIT study is an observational cross-sectional study designed to examine gait in older community dwellers reporting subjective memory complaint. The sampling and data collection procedures have been described elsewhere [19]. In summary, subjective memory complaint was gathered using the Subjective Memory Complaints Questionnaire [20], and the main exclusion criteria were age <60 years, Mini-Mental State Examination (MMSE) score <10 [21], inability to walk independently, history of stroke, occurrence of any acute medical illness within the past 3 months, current delirium, severe depression, and inability to understand or answer the study questionnaires.…”

Section: Methodsmentioning

confidence: 99%

Hypovitaminosis D and Executive Dysfunction in Older Adults with Memory Complaint: A Memory Clinic-Based Study

Annweiler¹,

Maby

Meyerber

et al. 2013

Dement Geriatr Cogn Disord

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Background: Hypovitaminosis D is associated with executive dysfunction as a whole. The purpose of this cross-sectional study was to determine whether lower vitamin D levels were associated with mental flexibility, information updating, or cognitive and motor inhibition among older adults. Methods: One hundred Caucasian older community dwellers with memory complaint (mean, 71.02 ± 0.74 years; 52.0% female) were divided into 3 groups according to serum 25-hydroxyvitamin D (25-OHD) concentration (deficiency <25 nmol/l, insufficiency 25-50 nmol/l, sufficiency >50 nmol/l). Executive functions were assessed with error rates by executing the Trail Making Test-B (TMT-B) for mental flexibility, the N-Back Test for information updating, the Stroop Interference Test for cognitive inhibition, and the Go/No-Go score for motor inhibition. Age, gender, BMI, education level, number of morbidities, depressive symptoms, Mini-Mental State Examination score, calcemia, estimated glomerular filtration rate and season tested were considered as potential confounders. Results: Compared to participants with vitamin D insufficiency and sufficiency, those with vitamin D deficiency had a poorer TMT-B performance (p = 0.019 and p = 0.017, respectively) but similar N-Back (p = 0.175), Stroop (p = 0.135) and Go/No-Go (p = 0.224) scores. Cognitive performance did not differ between participants with insufficient and sufficient vitamin D levels. Vitamin D deficiency was associated with poorer performance on TMT-B (adjusted β = 1.48, p = 0.011), but not on N-Back (p = 0.665), Stroop (p = 0.817) or Go/No-Go (p = 0.971). Conclusion: Vitamin D deficiencywas associated with poorer mental flexibility among older community dwellers with memory complaint.

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“…Hypovitaminosis D is also highly associated with cognitive disorders, especially with advanced-stage dementia (8,9). Mild cognitive impairment (MCI) is the early stage of cognitive dysfunction, causing memory complaints without a disturbance in daily life activities, and is encountered with an increasing prevalence of AD (10). Although there are some studies examining the relationship between cognitive decline and vitamin D levels, to the best of our knowledge, it is not well documented and there is no consensus in the literature about the relationship between serum 25-hydroxyvitamin D level and patients' cognitive status.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D status and its association with gradual decline in cognitive function

Yeşil¹,

Kuyumcu²,

Kara³

et al. 2015

Turk J Med Sci

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Background/aim: To compare plasma vitamin D concentrations among patients with normal cognitive function (control group), mild cognitive impairment (MCI), and Alzheimer disease (AD). Materials and methods:In total, 158 patients with AD, 228 patients with MCI, and 603 control subjects were included. Plasma levels of 25-hydroxyvitamin D were measured after comprehensive geriatric assessment and compared among groups. SPSS 15.0 was used for statistical analysis.Results: Mean levels of 25-hydroxyvitamin D were significantly different among the 3 groups of AD patients, MCI patients, and controls (P < 0.001). Post hoc analysis revealed that the levels were significantly lower in the MCI group than the control group (P = 0.002) and significantly lower in the AD group than the control group (P = 0.003). Multivariate analysis showed that age (OR: 1.

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Vitamin D insufficiency and mild cognitive impairment: cross‐sectional association

Abstract: Low 25OHD concentrations were associated with MCI status in older non-demented community-dwellers with subjective memory complaint.

Cited by 76 publications

References 39 publications

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Hypovitaminosis D and Executive Dysfunction in Older Adults with Memory Complaint: A Memory Clinic-Based Study

Vitamin D status and its association with gradual decline in cognitive function

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