Evaluation and diagnosis of the hair loss patient

Mubki, Thamer; Rudnicka, Lidia; Olszewska, Małgorzata; Shapiro, Jerry

doi:10.1016/j.jaad.2014.04.070

Cited by 105 publications

(62 citation statements)

References 48 publications

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“…Although a positive family history is frequent, a negative family history of AGA does not exclude the diagnosis [1,54].…”

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

“…This procedure is repeated in different areas of the scalp: frontal, occipital and temporal regions. The hair pull test is considered positive if more than 10% of telogen hairs are released, this means that if the pull test has more than 5 or 6 hair indicates ongoing hair activity [54,59].…”

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

“…Usually, scalp biopsy is the standard technique for diagnosing different types of scarring alopecia [54]. In addition, scalp biopsy could give relevant information in difficult cases of non scarring alopecia, where the diagnosis of the type of alopecia is uncertain.…”

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

“…Biopsies taken with a smaller punch than 4 mm in diameter are not recommended as it would give less number of follicle units, and as the follicles are not always affected simultaneously by a such disease it would diminishes the probability of a correct diagnosis [26]. The biopsy specimen should include the entire follicular unit and reach into the subcutaneous tissue where normally are the bulbs of anagen hair follicles [54,64].…”

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

“…A horizontal sectioning of the scalp biopsy specimen would give more quantitative and morphometric data and allowed a visualization of a larger number of follicles, diameter and grouping whereas the vertical section would provide more information about the length of the hair follicle and full dermal thickness and this was a diagnostic advantage, especially in scarring alopecia [54,65,66]. It remains uncertain if biopsies should be oriented horizontally or vertically [26].…”

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

See 4 more Smart Citations

Androgenetic Alopecia: a Review and Emerging Treatments

Alves¹

2017

CRDOA

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Androgenetic Alopecia (AGA) is the most common noncicatricial alopecia that leads to the progressive miniaturization of the hair follicle. Scalp terminal hairs are converted into vellus hairs, primarily due to two factors: genetic predisposition and hormonal stimulation.The incidence and prevalence of AGA increases with age. The onset of AGA is gradual, and when this pathology progresses, the anagen phase shortens and the telogen phase remains constant. The shedding area varies from patient to patient and is usually most marked at the vertex in men, while women with AGA generally lose hair diffusely over the crown.Topical minoxidil and oral finasteride (5-alpha-reductase type II inhibitor) are the gold-standard therapies for AGA and are currently the only Food and Drug Administration (FDA)-approved drugs for the treatment of AGA.The currently available treatments for AGA are sometimes perceived as having limited effectiveness; therefore, the identification of new therapies for this pathology is of utmost importance.This article aims to review the pathogenesis, diagnosis of AGA and all the new emerging treatments for this entity in order to prevent its progression and improve the results of this pathology.

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“…Although a positive family history is frequent, a negative family history of AGA does not exclude the diagnosis [1,54].…”

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

Section: Pathophysiology Of Androgenetic Alopeciamentioning

confidence: 99%

See 3 more Smart Citations

Androgenetic Alopecia: a Review and Emerging Treatments

Alves¹

2017

CRDOA

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Diagnosis and Treatment of Nonscarring Hair Loss in Primary Care in 2021

Mirmirani

2021

JAMA

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The Skin and Endocrine Disorders

Paus

2016

Rook's Textbook of Dermatology, Ninth Edition

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Given that the skin is a major target organ of numerous hormones for which it expresses functional receptors, it is not surprising that excessive or insufficient systemic levels of these hormones induce clinically relevant cutaneous responses. These can manifest as general skin symptoms and signs such as pruritus, skin dryness, seborrhoea, hair loss, hypertrichosis, hirsutism, hyperhidrosis and/or hyperpigmentation, any of which prompts consideration of an underlying endocrine disease. In addition, characteristic skin lesions such as palmar erythema, gingival hyperpigmentation, stretch marks (striae distensae), acanthosis nigricans, pretibial myxoedema, necrobiosis lipoidica, melasma and acneform eruptions provide invaluable diagnostic clues to the possibility of unrecognized endocrine disease. More recently, the field has been revolutionized by the recognition that human skin is also a major endocrine and neuroendocrine organ which produces and/or metabolizes not only all classes of steroid hormones but also multiple peptide (neuro‐) hormones, neuropeptides and neurotransmitters. These impact profoundly on skin physiology and pathology at multiple levels, ranging from skin barrier function and neurogenic skin inflammation via wound healing to cutaneous stress responses. This has important implications for future dermatological therapy.

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Evaluation and diagnosis of the hair loss patient

Cited by 105 publications

References 48 publications

Androgenetic Alopecia: a Review and Emerging Treatments

Androgenetic Alopecia: a Review and Emerging Treatments

Diagnosis and Treatment of Nonscarring Hair Loss in Primary Care in 2021

The Skin and Endocrine Disorders

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