Evaluating the ototoxicity of topical piperacillin–tazobactam

Jang, Chul Ho; Park, Haekyun; Cho, Yong Bum; Choi, Cheol-Hee

doi:10.1016/j.ijporl.2008.08.018

Cited by 7 publications

(5 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We have evaluated the ototoxicity of a topical fortified piperacillin-tazobactam solution by performing experiments in young male albino guinea pigs. The use of topical piperacillin-tazobactam showed no ototoxicity [15].…”

Section: Discussionmentioning

confidence: 87%

“…Recently we have reported the presence of ciprofloxacinresistant P. aeruginosa (CRPA) biofilms on infected tympanostomy tubes in intractable post-tymanostomy tube otorrhea [10]. Piperacillin-tazobactam is an effective antibiotic against CRPA otorrhea [15]. In this study, we evaluated the resistance of tympanostomy tubes coated with piperacillintazobactam to prevent CRPA biofilm formation in vitro.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The use of piperacillin–tazobactam coated tympanostomy tubes against ciprofloxacin-resistant Pseudomonas biofilm formation: An in vitro study

Jang¹,

Park²,

Cho³

et al. 2009

International Journal of Pediatric Otorhinolaryngology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

The use of piperacillin–tazobactam coated tympanostomy tubes against ciprofloxacin-resistant Pseudomonas biofilm formation: An in vitro study

Jang¹,

Park²,

Cho³

et al. 2009

International Journal of Pediatric Otorhinolaryngology

Self Cite

View full text Add to dashboard Cite

“…New bone formation was evident between the empty defects and defects filled with b-TCP particles. Piperacillin-tazobactam does not exhibit local ototoxicity [24]. The porosity of b-TCP delivers a higher drug concentration that is sufficient to maintain local antibiotic levels many times above the minimum bacterial concentration over a post-operative period.…”

Section: Discussionmentioning

confidence: 97%

Effect of piperacillin-tazobactam coated β-tricalcium phosphate for mastoid obliteration in otitis media

Jang

Cho

Yang

et al. 2011

International Journal of Pediatric Otorhinolaryngology

Self Cite

View full text Add to dashboard Cite

“…It combines the high antibiotic activity of piperacillin with β-lactamase inhibitor properties of Tazobactam that helps to maintain the susceptibility of bacteria to the antibiotic and prevents resistance. As a result, the combination has increased the range of bacteria that piperacillin can kill [1]. With the advent of increasing drug resistance to most antibiotics, this combination is an example of successful strategy to fight the menace.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Comparative Characterization of Methylcellulose, Carbomer and Petrolatum Gels for Topical and Transdermal Delivery of Zosyn (Piperacillin/Tazobactam) Antibiotics

Yeboah¹,

Ltd²

2020

PPPS

View full text Add to dashboard Cite

Piperacillin/Tazobactam otherwise known as Zosyn is a broad-spectrum combination antibiotic used to treat severe infections. It combines the high antibiotic activity of piperacillin with β-lactamase inhibitor properties of tazobactam that helps to restore the susceptibility of bacteria to the antibiotic and prevents resistance. Despite this interesting pharmacological profile, Zosyn is given intravenously because of its poor oral absorption and short half-life of between only 0.8 and 1.1 hours. However, this system of delivery is not convenient because it is invasive, requires continuous monitoring of patients, and incompatibility issues with other intravenous therapy. The purpose of this study, therefore, was to comparatively characterize an extended release gel formulation from Methylcellulose, Carbomer and Petrolatum and evaluate their suitability for topical and transdermal administration of the drug.Methodology: Gels with 1%, 5% and 10% drug loadings were prepared with the three polymers. The physical characterization of the formulations was done for: drug release using dissolution apparatus; percutaneous absorption in rat skin using microporation technique and Franz cell apparatus. Drug stability studies were conducted at 25°C, 37°C and 45°C and at skin pH of 5. The formulations were also tested for chemical degradation under acidic/ basic and oxidizing/reduction conditions similar to those found on the skin and in wounds with 0.01mol/l HCL, 0.01 mol/l NaOH, 0.1% H 2 O 2 , and 1M KI for 2 hours. Results:The results showed that the gel with 10% drug loaded Methylcellulose formulation was more stable at temperatures studied and less susceptible to chemical degradation for all the chemicals used. The release of drug from the formulations was relatively high in the Methylcellulose (40.9%) and Carbomer (27.59%) gels but were limited in the Petrolatum (3.97%). Furthermore, transdermal delivery using microporation showed high permeation of 12.7%, 6.08% and 6.97% for the 10% drug loaded gels of Methylcellulose, Carbomer and Petrolatum respectively. The drug in the Methylcellulose was found to be subjected to higher degradation in basic medium by an oxidation pathway. Conclusion:The 5% methylcellulose gel formulation containing 10% Zosyn loading was found to have the most potential for effective topical administration and extended-release transdermal delivery of the Zosyn.

show abstract

Evaluating the ototoxicity of topical piperacillin–tazobactam

Cited by 7 publications

References 17 publications

The use of piperacillin–tazobactam coated tympanostomy tubes against ciprofloxacin-resistant Pseudomonas biofilm formation: An in vitro study

The use of piperacillin–tazobactam coated tympanostomy tubes against ciprofloxacin-resistant Pseudomonas biofilm formation: An in vitro study

Effect of piperacillin-tazobactam coated β-tricalcium phosphate for mastoid obliteration in otitis media

Formulation and Comparative Characterization of Methylcellulose, Carbomer and Petrolatum Gels for Topical and Transdermal Delivery of Zosyn (Piperacillin/Tazobactam) Antibiotics

Contact Info

Product

Resources

About