Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats

Wali, Bushra; Sayeed, Iqbal; Guthrie, David B.; Natchus, Michael G.; Turan, Nefize; Liotta, Dennis; Stein, Donald G.

doi:10.1016/j.neuropharm.2016.05.017

Cited by 14 publications

(19 citation statements)

References 61 publications

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“…Although the behavioral analyses show overwhelming positive effects of progesterone treatment after TBI, this is not as obvious in analysis of the lesion volume using different TBI animal models. Only about half of the studies show a beneficial progesterone effect, with smaller lesion areas in both sexes compared to their vehicle treated controls (Cutler et al, 2006a; Geddes et al, 2014; Grossman et al, 2011; Jones et al, 2005; Peterson et al, 2015; Shear et al, 2002; Wali et al, 2016), while the others report no difference (Djebaili et al, 2004; Gilmer et al, 2008; Hua et al, 2012; Mannix et al, 2014; Nudi et al, 2015; Roof et al, 1994; Tang et al, 2013; Wali et al, 2011). Interestingly, Robertson et al (2015) show less percentage tissue loss in progesterone-treated CCI animals only in females, without sex differences in lesion volume (Robertson and Saraswati, 2015).…”

Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 98%

“…Sixteen studies alone have investigated the effect of progesterone treatment following TBI in males and females. In terms of cognitive outcomes, all but one CCI study (Nudi et al, 2015) report beneficial effects of progesterone treatment on hippocampal-dependent spatial learning in the MWM in a variety of different TBI models (Djebaili et al, 2004; Geddes et al, 2014; Hua et al, 2012; Jones et al, 2005; Li et al, 2012; Mannix et al, 2014; Roof et al, 1994; Shear et al, 2002; Si et al, 2013, 2014; Tang et al, 2013; Uysal et al, 2013; Wali et al, 2011, 2016; Webster et al, 2015). Two additional studies measuring hippocampal-dependent spatial learning with the Barnes Maze also reported beneficial effects of progesterone treatment after TBI induced with different methods (Nudi et al, 2015; O’Connor et al, 2007).…”

Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 99%

“…Additionally, motoric alterations after TBI using a wide range of different models show improvement with progesterone treatment in both male and female animals (Allitt et al, 2016; Baykara et al, 2013; Cekic et al, 2011, 2012; Cutler et al, 2006a; Djebaili et al, 2004; Geddes et al, 2014; Nudi et al, 2015; O’Connor et al, 2007; Peterson et al, 2015; Shear et al, 2002; Tang et al, 2013; Wali et al, 2011, 2016; Webster et al, 2015) with the exception of some studies (Grossman et al, 2011; Grossman and Stein, 2000). Interestingly, in a study using the CCI method in 4 week old mice, progesterone treatment only improved wire grip scores in male mice, but worsened performance in females (Mannix et al, 2014), suggesting that the hormonal status prior to injury could influence whether progesterone treatment is beneficial or not.…”

Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 99%

“…Conflicting reports regarding the effects of progesterone on edema formation in different animal TBI models have also been reported, with some showing beneficial effects (Guo et al, 2006; O’Connor et al, 2005; Pan et al, 2007; Roof et al, 1996; Shahrokhi et al, 2012; VanLandingham et al, 2006, 2007; Wali et al, 2016; Wright et al, 2001) and others reporting no difference (Gilmer et al, 2008; Jones et al, 2005). Wright et al (2001) show an inverse correlation between the degree of cerebral edema and serum progesterone levels, with less progesterone correlating with more edema in a CCI rat TBI model (Wright et al, 2001).…”

Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 99%

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Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Späni

Braun

Eldik

2018

Frontiers in Neuroendocrinology

130

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Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since men are more likely to experience a TBI because of more frequent participation in activities that increase risk of head injuries. This male bias is also reflected in preclinical research where mostly male animals have been used in basic and translational science. However, with an aging population in which TBI incidence is increasingly sex-independent due to falls, and increasing female participation in high-risk activities, the attention to potential sex differences in TBI responses and outcomes will become more important. These considerations are especially relevant in designing preclinical animal models of TBI that are more predictive of human responses and outcomes. This review characterizes sex differences following TBI with a special emphasis on the contribution of the female sex hormones, progesterone and estrogen, to these differences. This information is potentially important in developing and customizing TBI treatments.

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Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 98%

Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 99%

Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 99%

Section: Sex Differences In Animal Models Of Tbimentioning

confidence: 99%

See 2 more Smart Citations

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Späni

Braun

Eldik

2018

Frontiers in Neuroendocrinology

130

View full text Add to dashboard Cite

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“…[ 34 73 105 118 137 143 ] A water soluble progesterone analogue, which would facilitate its delivery in emergency conditions, has been recently developed. [ 138 ]…”

Section: Introductionmentioning

confidence: 99%

The role of inflammation and potential use of sex steroids in intracranial aneurysms and subarachnoid hemorrhage

Barrow¹,

Turan²,

Wangmo³

et al. 2018

Surg Neurol Int

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Background:Aneurysmal subarachnoid hemorrhage (aSAH) continues to be a devastating neurological condition with a high risk of associated morbidity and mortality. Inflammation has been shown to increase the risk of complications associated with aSAH such as vasospasm and brain injury in animal models and humans. The goal of this review is to discuss the inflammatory mechanisms of aneurysm formation, rupture and vasospasm and explore the role of sex hormones in the inflammatory response to aSAH.Methods:A literature review was performed using PubMed using the following search terms: “intracranial aneurysm,” “cerebral aneurysm,” “dihydroepiandrosterone sulfate” “estrogen,” “hormone replacement therapy,” “inflammation,” “oral contraceptive,” “progesterone,” “sex steroids,” “sex hormones” “subarachnoid hemorrhage,” “testosterone.” Only studies published in English language were included in the review.Results:Studies have shown that administration of sex hormones such as progesterone and estrogen at early stages in the inflammatory cascade can lower the risk and magnitude of subsequent complications. The exact mechanism by which these hormones act on the brain, as well as their role in the inflammatory cascade is not fully understood. Moreover, conflicting results have been published on the effect of hormone replacement therapy in humans. This review will scrutinize the variations in these studies to provide a more detailed understanding of sex hormones as potential therapeutic agents for intracranial aneurysms and aSAH.Conclusion:Inflammation may play a role in the pathogenesis of intracranial aneurysm formation and subarachnoid hemorrhage, and administration of sex hormones as anti-inflammatory agents has been associated with improved functional outcome in experimental models. Further studies are needed to determine the therapeutic role of these hormones in the intracranial aneurysms and aSAH.

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Progesterone for acute traumatic brain injury

Huang

Qin

et al. 2016

Cochrane Database of Systematic Reviews

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Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats

Cited by 14 publications

References 61 publications

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

The role of inflammation and potential use of sex steroids in intracranial aneurysms and subarachnoid hemorrhage

Progesterone for acute traumatic brain injury

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