Progesterone for acute traumatic brain injury

Ma, Junpeng; Huang, Suli; Qin, Shu Kui; You, Chao; Zeng, Yan

doi:10.1002/14651858.cd008409.pub4

Cited by 51 publications

(24 citation statements)

References 43 publications

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“…One study found no effect of menstrual cycle phase on symptoms, neurocognitive function, or postural stability in nonconcussed individuals [99]. Furthermore, clinical trials using exogenous progesterone in more severe traumatic brain injury have demonstrated uneven results [100]. Estrogen has also been theorized to provide a protective effect after TBI, but studies evaluating this have primarily been in animal models [101].…”

Section: Sports Concussionmentioning

confidence: 99%

Sex Differences in Common Sports Injuries

Lin

Casey

Herman

et al. 2018

PM&R

101

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Common sports injuries include bone stress injuries (BSIs), anterior cruciate ligament (ACL) injuries, and concussions. Less commonly recognized are the specific sex differences in epidemiology, risk factors, and outcomes of these conditions by sex. An understanding of these factors can improve their clinical management, from prescribing appropriate prehabilitation to guiding postinjury rehabilitation and return to play. This narrative review summarizes the sex differences in the diagnosis and management of BSIs, ACL injuries, and concussions. Although BSIs are more common in female athletes, risk factors for both sexes include prior injury and relative energy deficiency in sport (RED-S). Risk factors in female athletes include smaller calf girth, femoral adduction, and higher rates of loading. Female athletes are also at greater risk for developing ACL injuries in high school and college, but their injury rate is similar in professional sports. Increased lateral tibial slope, smaller ACL size, and suboptimal landing mechanics are additional risk factors more often present in female athletes. Male athletes are more likely to have ACL surgery and have a higher rate of return to sport. Concussions occur more commonly in female athletes; however, female athletes are also more likely to report concussions. Male athletes more commonly sustain concussion through contact with another player. Female athletes more commonly sustain injury from contact with playing equipment. Managing post-concussion symptoms is important, and female athletes may have prolonged symptoms. An understanding of the sex-specific differences in these common sports injuries can help optimize their prehabilitation and rehabilitation. LEVEL OF EVIDENCE: IV.

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Section: Sports Concussionmentioning

confidence: 99%

Sex Differences in Common Sports Injuries

Lin

Casey

Herman

et al. 2018

PM&R

101

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“…The search strategy was not restricted by language, date, participants race, gender or publication status; but date limitation implemented to the referencing databases (i.e., SCOPUS and Thomson Reuters Web of Science) for after 2000 search results, also limiting results to human studies where possible. 5 Use of Neuroprotective agents for Traumatic Brain Injury DOI: http://dx.doi.org/10.5772/intechopen.85720…”

Section: Search Methods For Identification Of Studiesmentioning

confidence: 99%

“…Traumatic brain injury (TBI), which is also known as head injury [1][2][3], is the leading cause of mortality and morbidity [1,[4][5][6], especially in young ages [1]; that is defined as "the occurrence of injury to the head, that is, associated with symptoms or signs attributable to the injury such as decreased level of consciousness, amnesia, other neurological or neuropsychological abnormalities, skull fracture, intracranial lesions or death." [6].…”

Section: Description Of the Conditionmentioning

confidence: 99%

“…The 2012 Cochrane review of "Progesterone for acute traumatic brain injury (Review)," based on three phase-II trials, declared that it would be updated as two more multi-centric clinical trials' results came out [5]; at the time of current review's searching for Neuroprotective agents, those mentioned trials and one more study been achieved [10,11,44]. Authors complete reading each one of the studies by comparing them to CONSORT 2010 checklist, finally included four studies [10,11,45,46] and excluded three of them [44,47,48].…”

Section: Progesteronementioning

confidence: 99%

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Use of Neuroprotective agents for Traumatic Brain Injury

Meshkini¹,

Meshkini²,

Sadeghi‐Bazargani³

2019

Traumatic Brain Injury - Neurobiology, Diagnosis and Treatment

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Traumatic brain injury (TBI) is the leading cause of mortality and morbidity especially in young ages, while over 30 years of neuroprotective agents use for TBI management provided neither any recommended agent for favorable outcome nor less adverse effects in TBI management yet. This review got selected keywords' search and ran in known international and local databases, with no limitation up to September 6, 2015. Related to the subject, clinical human studies have been selected for the review. Data from 32 studies were classified into 10 subgroups. About 18 studies with a population of 4637 participants were included in 6 topic reviews and meta-analyses. Oxygen use in acute management of TBI to reduce mortality rates could be recommended. Corticosteroid use in solo acute TBI management is prohibited due to increasing risk of mortalities. However, in dual-diagnosed patients (TBI and spinal cord injury (SCI) together), corticosteroid use should be obtained by a Bracken protocol. The use of citicoline in acute TBI is no more supported. The use of cyclosporine-A for ICP control depends on the resources and physician's decision. Rivastigmine use for chronic neurocognitive conditions of TBI management had some beneficence in severely impaired participants. However, the use of other agents in TBI has no field of support yet.Keywords: traumatic brain injury, head injury, neuroprotective agents, systematic review, meta-analysis Literature reviewThere are wide variety of Neuroprotective agents, and breadth studies on human and animal cases, the following lists the agents which were studied on human clinical trials: OxygenThe vital element of life and viability of neurons. Hypoxia leads to anaerobic metabolism, acidosis, and reduction in cellular metabolism. Neurons messaging conduction ability disturbs due to loss of their ability to maintain ionic homeostasis.2 Traumatic Brain Injury -Neurobiology, Diagnosis and Treatment Use of Neuroprotective agents for Traumatic Brain Injury DOI: http://dx.

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“…A 2012 Cochrane review concluded that progesterone may improve the neurologic outcome of patients suffering from TBI, but further studies are needed to better understand how progesterone may benefit this population. 17…”

Section: Role Of Progesterone In Tbimentioning

confidence: 99%

Pharmacological Management of Traumatic Brain Injury and Implications for Speech Language Pathology

Rivera

2014

Semin Speech Lang

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This article provides an overview of the pharmacological management of traumatic brain injury (TBI). A basic introduction to key pharmacokinetic and pharmacodynamic principles is used to guide the reader. The goals of the pharmacological management of TBI are explained starting with mild TBI. The main medications used for each medical condition are described with a primary emphasis of effects that may interfere with the role of speech-language pathology (SLP). Some medications may interfere with cognitive, motor, and neuromuscular functions, and others may cause ototoxicity. A basic overview of the pharmacological management of moderate to severe TBI is included because the SLP practitioner may encounter patients with TBI during the recovery phase. The importance of assessment of swallowing evaluations is discussed because the oral route of administration of medications is preferred once the patient is stable.

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Progesterone for acute traumatic brain injury

Cited by 51 publications

References 43 publications

Sex Differences in Common Sports Injuries

Sex Differences in Common Sports Injuries

Use of Neuroprotective agents for Traumatic Brain Injury

Pharmacological Management of Traumatic Brain Injury and Implications for Speech Language Pathology

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