Evaluating the efficacy of an algae-based treatment to mitigate elicitation of antibiotic resistance

Grimes, Kassandra L.; Dunphy, Laura J.; Loudermilk, Erica M.; Melara, A. Jasmin; Kolling, Glynis L.; Papin, Jason A.; Colosi, Lisa M.

doi:10.1016/j.chemosphere.2019.124421

Cited by 20 publications

(5 citation statements)

References 47 publications

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“…Grimes et al concluded efficient reduction in the pEX18Tc plasmid transformation, complete reduction of plasmid transformation, and 67% reduction in the transformation of plasmid in autoclaved algae [205]. In this context, a study confirmed the removal of induced ciprofloxacin resistance with freshwater algae treatment [206]. Another study compared the conventional wastewater treatment system with the algalbased system to remove antibiotic-resistant genes and bacteria.…”

Section: Passive Immunization (Monoclonal Antibodiesmentioning

confidence: 99%

Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Ahmed

Rafique

et al. 2023

BioMed Research International

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Antimicrobial resistance (AMR) is a ubiquitous public health menace. AMR emergence causes complications in treating infections contributing to an upsurge in the mortality rate. The epidemic of AMR in sync with a high utilization rate of antimicrobial drugs signifies an alarming situation for the fleet recovery of both animals and humans. The emergence of resistant species calls for new treatments and therapeutics. Current records propose that health drug dependency, veterinary medicine, agricultural application, and vaccination reluctance are the primary etymology of AMR gene emergence and spread. Recently, several encouraging avenues have been presented to contest resistance, such as antivirulent therapy, passive immunization, antimicrobial peptides, vaccines, phage therapy, and botanical and liposomal nanoparticles. Most of these therapies are used as cutting-edge methodologies to downplay antibacterial drugs to subdue the resistance pressure, which is a featured motive of discussion in this review article. AMR can fade away through the potential use of current cutting-edge therapeutics, advancement in antimicrobial susceptibility testing, new diagnostic testing, prompt clinical response, and probing of new pharmacodynamic properties of antimicrobials. It also needs to promote future research on contemporary methods to maintain host homeostasis after infections caused by AMR. Referable to the microbial ability to break resistance, there is a great ultimatum for using not only appropriate and advanced antimicrobial drugs but also other neoteric diverse cutting-edge therapeutics.

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Section: Passive Immunization (Monoclonal Antibodiesmentioning

confidence: 99%

Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Ahmed

Rafique

et al. 2023

BioMed Research International

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“…A recent algae-based tertiary treatment was found to reduce effluent-induced resistance to ciprofloxacin (Grimes et al, 2019). A more recent review of microalgae-based technologies reports that removal performance by algae depends on the antibiotic and algal species and that the antibiotic removal is mainly by adsorption, accumulation, and degradation.…”

Section: Source Of Antimicrobial Pollutionmentioning

confidence: 99%

Antimicrobial Resistance in Rivers: A Review of the Genes Detected and New Challenges

Grenni

2022

Enviro Toxic and Chemistry

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River ecosystems are very important parts of the water cycle and an excellent habitat, food, and drinking water source for many organisms, including humans. Antibiotics are emerging contaminants which can enter rivers from various sources. Several antibiotics and their related antibiotic resistance genes (ARGs) have been detected in these ecosystems by various research programs and could constitute a substantial problem. The presence of antibiotics and other resistance cofactors can boost the development of ARGs in the chromosomes or mobile genetic elements of natural bacteria in rivers. The ARGs in environmental bacteria can also be transferred to clinically important pathogens. However, antibiotics and their resistance genes are both not currently monitored by national or international authorities responsible for controlling the quality of water bodies. For example, they are not included in the contaminant list in the European Water Framework Directive or in the US list of Water-Quality Benchmarks for Contaminants. Although ARGs are naturally present in the environment, very few studies have focused on non-impacted rivers to assess the background ARG levels in rivers, which could provide some useful indications for future environmental regulation and legislation. The present study reviews the antibiotics and associated ARGs most commonly measured and detected in rivers, including the primary analysis tools used for their assessment. In addition, other factors that could enhance antibiotic resistance, such as the effects of chemical mixtures, the effects of climate change, and the potential effects of the coronavirus disease 2019 pandemic, are discussed.

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“…Additionally, they are hardy, capable of growing under extreme conditions and capable of fixing up atmospheric nitrogen. Successful examples of algal bioremediation of antibiotics are well presented and reviewed in the literature (Grimes et al 2019;Xiao et al 2021;Zhou et al 2021). It is, however, important to monitor the production of algal toxins before selecting the algae of choice for bioremediation.…”

Section: Future Directionsmentioning

confidence: 99%

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Stanley

Batacan

Bajagai

2022

Appl Microbiol Biotechnol

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The control of infectious diseases has always been a top medical priority. For years during the so-called antibiotic era, we enjoyed prolonged life expectancy and the benefits of superior pathogen control. The devastating failure of the medical system, agriculture and pharmaceutical companies and the general population to appreciate and safeguard these benefits is now leading us into a grim post-antibiotic era. Antimicrobial resistance (AMR) refers to microorganisms becoming resistant to antibiotics that were designed and expected to kill them. Prior to the COVID-19 pandemic, AMR was recognised by the World Health Organization as the central priority area with growing public awareness of the threat AMR now presents. The Review on Antimicrobial Resistance, a project commissioned by the UK government, predicted that the death toll of AMR could be one person every 3 seconds, amounting to 10 million deaths per year by 2050. This review aims to raise awareness of the evergrowing extensiveness of antimicrobial resistance and identify major sources of this adversity, focusing on agriculture’s role in this problem and its solutions. Keypoints • Widespread development of antibiotic resistance is a major global health risk. • Antibiotic resistance is abundant in agricultural produce, soil, food, water, air and probiotics. • New approaches are being developed to control and reduce antimicrobial resistance.

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Evaluating the efficacy of an algae-based treatment to mitigate elicitation of antibiotic resistance

Cited by 20 publications

References 47 publications

Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Antimicrobial Resistance in Rivers: A Review of the Genes Detected and New Challenges

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

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