Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Ahmed, Sarfraz; Ahmed, Muhammad Zeeshan; Rafique, Safa; Almasoudi, Seham Eid; Shah, Mohibullah; Jalil, Nur Asyilla Che; Ojha, Suvash Chandra

doi:10.1155/2023/5250040

Cited by 19 publications

(10 citation statements)

References 240 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different types of antibiotic adjuvants, along with examples, are presented in Table 2. Class I can be further differentiated into Class IA and Class IB based on their mechanisms of action (Ahmed et al, 2023). Class IA adjuvants are also known as "inhibitors of active resistance," as they are capable of directly inhibiting antibiotic resistance.…”

Section: Types Of Antibiotic Adjuvantsmentioning

confidence: 99%

Antibiotic adjuvants: synergistic tool to combat multi-drug resistant pathogens

Kumar,

Yasmeen,

Pandey

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

The rise of multi-drug resistant (MDR) pathogens poses a significant challenge to the field of infectious disease treatment. To overcome this problem, novel strategies are being explored to enhance the effectiveness of antibiotics. Antibiotic adjuvants have emerged as a promising approach to combat MDR pathogens by acting synergistically with antibiotics. This review focuses on the role of antibiotic adjuvants as a synergistic tool in the fight against MDR pathogens. Adjuvants refer to compounds or agents that enhance the activity of antibiotics, either by potentiating their effects or by targeting the mechanisms of antibiotic resistance. The utilization of antibiotic adjuvants offers several advantages. Firstly, they can restore the effectiveness of existing antibiotics against resistant strains. Adjuvants can inhibit the mechanisms that confer resistance, making the pathogens susceptible to the action of antibiotics. Secondly, adjuvants can enhance the activity of antibiotics by improving their penetration into bacterial cells, increasing their stability, or inhibiting efflux pumps that expel antibiotics from bacterial cells. Various types of antibiotic adjuvants have been investigated, including efflux pump inhibitors, resistance-modifying agents, and compounds that disrupt bacterial biofilms. These adjuvants can act synergistically with antibiotics, resulting in increased antibacterial activity and overcoming resistance mechanisms. In conclusion, antibiotic adjuvants have the potential to revolutionize the treatment of MDR pathogens. By enhancing the efficacy of antibiotics, adjuvants offer a promising strategy to combat the growing threat of antibiotic resistance. Further research and development in this field are crucial to harness the full potential of antibiotic adjuvants and bring them closer to clinical application.

show abstract

Section: Types Of Antibiotic Adjuvantsmentioning

confidence: 99%

Antibiotic adjuvants: synergistic tool to combat multi-drug resistant pathogens

Kumar,

Yasmeen,

Pandey

et al. 2023

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Lemak merupakan cadangan energi bagi hewan dan menjalankan berbagai fungsi, seperti menjaga suhu tubuh, sekaligus merupakan konstituen utama membran sel dan berfungsi sebagai pembawa pesan kimiawi (Ratnayake & Galli, 2009;Tocher, 2003). Tubuh manusia membutuhkan berbagai jenis lemak lipid yang berguna untuk menjaga kesehatan fungsi-fungsi bagian tubuhnya (Ahmed et al, 2023). Menyeimbangkan kadar lipid dalam darah adalah bagian penting untuk tetap sehat.…”

Section: Pendahuluanunclassified

Proses Metabolisme Lipid Dalam Perspektif Al-Qur’an Dan Hadis

Daulay,

Tarigan,

Okatiani

et al. 2023

JRPP

View full text Add to dashboard Cite

Lipid metabolism is a process where fatty acids that enter the body are digested and then broken down as energi and later stored in the body for energi reserves. The lipids that we obtain as the main source of energi are neutral lipids, namely triglycerides (esters between glycerol and 3 fatty acids). This journal article aims to find out that lipid metabolism has a connection in the Qur'an and hadith. This research uses a qualitative approach through a case study of lipid metabolism from the Qur'anic perspective. The sources of research data are books, the Qur'an, and journals. In addition to these data sources, researchers also seek additional references from other data sources, namely a number of thesis literature, internet sources that are in accordance with the research. Lipid digestion results in the form of fatty acids and glycerol, some are still monoglycerides. As a result of it is water-soluble, glycerol enters the portal circulation (portal vein) of the liver. Other journal articles do not discuss the relationship between metabolism and the Qur'an and Al-Hadith, therefore this article can facilitate the relationship between the two, as stated in QS. Al-A'raf verse 31 and QS. Al-Mu'minunayat 21 which discusses fat content and lipid function.

show abstract

“…They generally grow up optimally at pH values beyond 9.0, but the growth is inhibited at the pH value that is most closely associated with neutral 6.5. 2,3 The general mechanism followed by Salt Tolerant microbes for surviving in varying saline conditions.…”

Section: Introductionmentioning

confidence: 99%

Salt Tolerant Microbes (Active Metabolites) Mediated Nanoparticle: Drug Delivery and Future Prospects

Priya,

Joshi,

Rautela

et al. 2024

J. Pure Appl. Microbiol.

View full text Add to dashboard Cite

Salt Tolerant Microbes are a group of microorganisms that grow, develop, and survive in extremely high salt concentrations. Based on their tolerance level they generally grow up optimally at pH values beyond 9.0, but the growth is inhibited at the pH value that is most closely associated with neutral 6.5. They have minimal dietary needs and a good salt quantity that is high enough to osmotic pressure. They can produce biological metabolites that have certain actions such as antibacterial, antifungal, antioxidant, and anticancer. We discussed in this article various pharmaceutical formulations of salt-tolerant microbes, every formulation shows the specific pharmacological actions like anti-cancer activity, anti-oxidant activity, and anti-microbial activity, and also discusses methods for the biosynthesis of salt-tolerant microbes’ nanoparticles.

show abstract

Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms

Cited by 19 publications

References 240 publications

Antibiotic adjuvants: synergistic tool to combat multi-drug resistant pathogens

Antibiotic adjuvants: synergistic tool to combat multi-drug resistant pathogens

Proses Metabolisme Lipid Dalam Perspektif Al-Qur’an Dan Hadis

Salt Tolerant Microbes (Active Metabolites) Mediated Nanoparticle: Drug Delivery and Future Prospects

Contact Info

Product

Resources

About