Evaluating the efficacy of a ferrous-ion-chelating peptide from Alaska pollock frame for the improvement of iron nutritional status in rats

Abstract

Ferrous-ion-chelating peptides from the Alaska pollock frame are effective in improving the iron nutritional status in IDA rats.

The Preparation, Antioxidant Activity Evaluation, and Iron-Deficient Anemic Improvement of Oat (Avena sativa L.) Peptides–Ferrous Chelate

“…Fifty rats were fed with an iron-deficient diet (5 mg Fe/kg diet, Synergetic Bioengineering Co. Ltd., Nanjing, China) for 21 days to generate an IDA rat model. After 21 days, the blood of model rats ( n = 50) was collected by orbital venipuncture into anticoagulant blood vessels for the hematological test, and IDA was defined as hemoglobin (Hb) values below 100 g/L ( 10 ). After the IDA rat model was established, the control group was still fed with a standard diet, and 50 IDA rats were randomly subdivided into five groups and still fed with an iron-deficient diet (5 mg Fe/kg/day).…”

“…Some ferrous-iron chelating peptides have been discovered and characterized, which can be used as iron supplements. For example, ferrous-iron-chelating peptides from Alaska pollock frames (APFP-Fe) are a useful iron source for improving iron nutritional status in iron deficiency anemic rats ( 10 ). Chickpea peptides, through metal chelation, may increase iron solubility and bioavailability, and improve iron absorption ( 11 ).…”

Electrically Switchable Nanolever Technology for the Screening of Metal-Chelating Peptides in Hydrolysates

“…5 However, their bioavailability is poor due to their low solubility in human fluids. 6 Metal-chelating peptides (MCPs) contribute to minerals absorption and bioavailability, 6 thus regulating ion concentrations through selective bindings. 4 Finally, iron and copper-chelating peptides -while complexing these transient metal ions -can act as indirect antioxidants by inhibiting in vivo the Fenton and Haber-Weiss reactions responsible for the formation of reactive oxygen species (including the hydroxyl radical) and subsequent radical chain reactions.…”

“…Metal-ion chelation is a functional property commonly investigated in the literature. , Indeed, metals ions such as iron, zinc, calcium, and copper are essential for several biological functions such as enzyme catalysis, oxygen transport, and neurotransmitter release . However, their bioavailability is poor due to their low solubility in human fluids . Metal-chelating peptides (MCPs) contribute to mineral absorption and bioavailability, thus regulating ion concentrations through selective bindings .…”

Microalgal nanosized polyphosphate bodies as novel iron supplements for iron-deficiency anemia treatment in rats

“…Dietary iron supplementation is the most commonly used strategy to decrease iron deficiency rate, suitable for large populations (Pritwani & Mathur, 2015;Shrimpton & Schultink, 2002). Several iron supplements, such as FeSO 4 , ferric citrate (FC), and FeCl 3 , were reported to be effective on iron-deficiency anemia (Block et al, 2015;Bries et al, 2019;Chaud et al, 2002;Ma et al, 2019). Among which, FeSO 4 is commonly used as gold iron supplement.…”