Evaluating the Effects of a Topical Preparation with Dexpanthenol, Silbiol, Undecylenic Acid, and Lidocaine on Palatal Mucosa Wound Healing in a Rat Model

Abstract

Background:Postoperative complications occur after periodontal plastic surgeries, but an ideal treatment to overcome them has not been found yet.Aims:To evaluate the effects of topically applied Oral-norm gel on the healing of excisional wounds.Study Design:Animal experiment.Methods:Excisional wounds with a diameter of 3 mm were made in the center of the palatal mucosa of 63 Sprague Dawley rats. Seven animals were sacrificed at time 0. The remaining rats were divided into two groups: a test group in which the topical Oral-norm gel was applied three times a day and a control group in which nothing was applied. Seven animals in each group were sacrificed at 3, 7, 14, and 21 days. Mean wound surface area was measured photographically, while wound healing and width were evaluated microscopically.Results:The mean wound surface area decreased significantly after 3 days in both groups (p<0.001). Between days 3 and 7, the mean wound surface area decreased from 6.62 (2.85) to 0.83 (1.62) mm2 in the control group and 5.07 (0.88) to 1.42 (1.67) mm2 in the test group. The wound width decreased significantly on day 7 in both groups (p<0.001), with no further changes by day 14. Both groups had a significant increase in inflammation and vascularization on day 3 (p<0.001), with a reduction thereafter. No significant differences in macroscopic and microscopic measurements were observed between the groups at any time point (p>0.05).Conclusion:The Oral-norm gel has no positive healing effects in the palatal mucosa of rats.

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“…Therefore, DXP has an “antioxidative,” “anti‐inflammatory” effect and a cellular repair capability 2,4 . To date, DXP has been used in numerous diseases including hepatotoxicity, wound healing, nephropathy without serious side effects 5‐7 …”

An evaluation of the effects of caffeic acid phenethyl ester and ankaferd blood stopper on secondary wound healing of oral mucosal tissue

“…Those findings have provided the basis for future ABS clinical trials that will be designed for the oral-systemic administration to control haemorrhages of the gastrointestinal system tract [14]. Sezgin et al excisional wounds with a diameter of 3 mm were made in the centre of the palatal mucosa and they determined the number of subjects of each group to be 7 [15]. Ersel et al evaluated in vivo wound healing effects of a sericin-containing gel formulation in an incision wound model in rats and they determined the number of subjects of each group to be 7 [16].…”

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