An evaluation of the effects of caffeic acid phenethyl ester and ankaferd blood stopper on secondary wound healing of oral mucosal tissue

Gul, Mehmet; Günay, Ahmet; Tanık, Abdülsamet

doi:10.3906/sag-1908-114

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…Although fibrosis formation was statistically similar in both groups, the group treated with ABS had a lower rate of fibrosis than the untreated control group. More dense new bone formation and less necrosis were reported in defects treated with ABS, possibly as a result of an increase in healing speed and a decrease in inflammation associated with the antioxidant activity of ABS components (18,32).…”

Section: Discussionmentioning

confidence: 95%

Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants

et al. 2022

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Aim: Investigations into Ankaferd Blood Stopper® (ABS) on bone healing have revealed positive bone regeneration effects. The exact mechanism of this positive bone tissue metabolism effect is unknown. This study’s aim is a biomechanic and biochemical investigation of the effects of local ABS application on the osseointegration of titanium implants. Methodology: Sprague Dawley rats were divided into four groups of ten rats each. The control group (n=20) received no treatment during the experimental period, while the ABS group (n=20) had ABS applied locally during the surgical application of the titanium implant before insertion into the bone sockets. After 2 (controls n=10 and ABS n=10) and 4 weeks (controls n=10 and ABS n=10) experimental periods, the rats were sacrificed and implants with surrounding bone tissues were removed for reverse torque analysis (Newton), blood sample collection, and biochemical analysis. Results: The biomechanic bone implant contact ratio detected was higher in week 4 than in week 2 in the ABS group (p<0, 05). Lower phosphor levels were detected in the ABS group than in the 4-week controls (p<0, 05). Conclusion: According to the biomechanical parameters, ABS is more effective after four weeks than after two weeks when locally applied. How to cite this article: Özcan EC, Gül M, Tanık A, Yıldırım TT, Özkan M, Bozoğlan A, Özdemir HE, Dündar S. Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants. Int Dent Res 2022;12(1):27-33. https://doi.org/10.5577/intdentres.2022.vol12.no1.5 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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Section: Discussionmentioning

confidence: 95%

Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants

et al. 2022

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“…Experimental studies evaluated the effect of different agents on wound healing [2][3][4][5]21]. These agents may be pharmaceutical/medical substances as shown by certain studies.…”

Section: Discussionmentioning

confidence: 99%

“…Most skin wounds heal naturally. Various agents were applied in previous studies to accelerate wound healing and increase wound strength [2][3][4][5]. Incisional wound model is often used in experimental and clinical studies.…”

Section: Introductionmentioning

confidence: 99%

“…ABS is a hemostatic agent used to control postoperative bleeding in patients with various bleeding disorders [13,14]. In addition to providing good hemostasis, ABS promotes neovascularization, which helps with rapid wound healing [5,10]. In this experimental study, we aimed to evaluate the mechanical and histopathological effects of ABS, which can be easily applied on clean surgical wounds, on wound healing.…”

Section: Introductionmentioning

confidence: 99%

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Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

Hancıoğlu¹,

Demirel²,

Bıçakçı³

et al. 2020

Turk J Med Sci

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Background/aim To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing. Materials and methods A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted with IBM SPSS program. P < 0.05 was considered significant. Results The mean burst pressure widths of wound separation were 13.66 ± 0.457, 7.18 ± 2.599, and 13.66 ± 1.11 mm for Groups 1–3, respectively. The difference in burst pressure width between Groups 1 and 3 was not significant (P > 0.05) but was significant between Groups 2 and 3 (P = 0.000). The vascular proliferation median values were 1, 2, and 2, for Groups 1–3, respectively. Although the difference was significant between Groups 1 and 2 in terms of vascular proliferation score (P = 0.047), no significant difference was observed between Group 3 and others. No statistically significant difference was observed among the groups in terms of collagen score, mononuclear cell infiltration, and polymorphonuclear cell proliferation (P > 0.05). The median values of fibroblast proliferation score were 1, 2, and 3, in Groups 1–3, respectively. Fibroblast proliferation score significantly differed between Groups 1 and 3 (P = 0.003). Conclusion ABS application results in a clean wound healing that is as strong as primary repair. However, additional studies are required to evaluate the late results of increased fibroblastic activity in the early period of ABS application alone.

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“…Studies have reported that ABS has strong antimicrobial properties along with its effectiveness in bleeding control [11]. In the studies it was suggested that ABS can be used in dental treatments because of its hemostatic activity and strong antimicrobial properties [12,13].…”

Section: Introductionmentioning

confidence: 99%

The effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper on the diabetic and nondiabetic gingival wound healing: an experimental study

Gul¹,

Dündar²,

Artaş³

et al. 2021

Turk J Med Sci

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Background/aim Healthy wound healing is very important for patient comfort. Diabetes is one of the factors that negatively affect wound healing. Ankaferd Blood Stopper (ABS) and caffeic acid phenethyl ester (CAPE) are antiinflammatory and antimicrobial agents and may have positive effects on wound healing. Materials and methods In this study, 72 male Wistar albino rats were used. Rats; control, CAPE, ABS, diabetes + control, diabetes + ABS and diabetes + CAPE groups were divided into 6 groups. A healthy 36 rats created diabetes using streptozotocin (STZ). A gingival wound was created using a 4-mm punch biopsy in the gingival tissue under the lower anterior incisors of the rats. Results The comparison between the nondiabetic groups had a statistically significant positive effect compared to the control group of CAPE and ABS (P ˂ 0.05). In the comparison between ABS and diabetes + ABS groups and in the comparison between CAPE and diabetes + CAPE groups, a decrease in vascularization in diabetes + CAPE groups was observed and it was statistically significant (P ˂ 0.005). Conclusion ABS and CAPE have been found to have positive effects on gingival wound healing in the nondiabetic group. We think that this situation is caused by its antiinflammatory and antimicrobial properties.

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An evaluation of the effects of caffeic acid phenethyl ester and ankaferd blood stopper on secondary wound healing of oral mucosal tissue

Cited by 7 publications

References 25 publications

Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants

Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants

Histopathological and mechanical effects of Ankaferd Blood Stopper® on wound healing in rats: an experimental model

The effect of caffeic acid phenethyl ester and Ankaferd Blood Stopper on the diabetic and nondiabetic gingival wound healing: an experimental study

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