Evaluating the effect of coating equipment on tablet film quality using terahertz pulsed imaging

Crystallization and hardening of poly(ethylene-co-vinyl acetate) mouthguards during routine use

“…However, MRI cannot be applied till now owing to technical limitations in resolution and signal/noise ratios33. Further development of NMR apparatus and/or application of other spectroscopic methodologies, such as terahertz (THz) imaging3435, will enable non-destructive detection of the crystallinity of EVA MGs.…”

Scale Up of Pan Coating Process Using Quality by Design Principles

“…Most of these techniques are destructive, have no capability to resolve multiple coating layers with a single‐point measurement, or may require the set‐up and maintenance of robust multivariate analysis models for data interpretation . Recently, both inter‐ and intratablet uniformities have been measured, with a trend toward novel nondestructive techniques, such as attenuated total reflection‐infrared imaging, NIR chemical imaging (NIR‐CI), terahertz pulsed imaging (TPI), optical coherence tomography (OCT), and X‐ray microcomputed tomography . The utility of some of these characterization techniques used to assess coating process and coating characteristics have been summarized in the subsequent subsections and in Table .…”

How to easily provide zero order release of freely soluble drugs from coated pellets

“…Numerous products based on coated tablets, pellets or capsules are available on the market. Importantly, the right choice of polymers, application techniques, and coated substrates allows providing large ranges of long term stable drug release profiles (e.g., Kolter et al, 2013;Sauer et al, 2013;Haaser et al, 2013). This includes for instance pulsatile drug delivery (Maroni et al, 2013a), site specific drug delivery to the colon, (Maroni et al, 2013b) and drug delivery at a constant rate (also called zero order release kinetics).…”