Evaluating the correlation of serum leptin levels with evidence of coronary artery disease on myocardial perfusion single-photon emission computed tomography in suspected coronary artery disease patients

Abstract

Background Cardiovascular disease is currently the most common cause of death worldwide. Several risk factors have been identified for cardiovascular diseases, including hypertension, hyperlipidemia and diabetes. Leptin is a peptide hormone that acts as a proinflammatory cytokine and has a variety of effects in hemostasis and metabolism such as lipid metabolism, production of glucocorticoid, angiogenesis, etc. The aim of this study was to determine the relationship between the concentrations of leptin with evidence of coronary artery disease in the myocardial perfusion scan. Method A one year retrospective cross-sectional study was conducted on patients who are suspected of coronary artery disease that referred to the nuclear medicine department for performing myocardial perfusion scan. The patients were classified based on the results of the myocardial perfusion scan. Serum leptin was measured with ELISA assay. The correlation of serum leptin with these parameters and also with different groups of age, sex and coronary artery disease risk factors was also compared. Results The mean serum level of leptin was 290.44 ng/ml (82.9-1600 ng/ml). There is no meaningful relation between serum leptin and coronary artery disease risk factors, age and sex; also, none of the quantitative myocardial perfusion scan parameters have a significant correlation with serum leptin. Conclusion Based on our findings, there was no significant correlation between myocardial perfusion scan parameters and leptin levels. Serum leptin and different groups of age, sex and coronary artery risk factors were not correlated as well.

Correlation of hypothyroidism with evidence of coronary artery disease in the myocardial perfusion scan

“…However, there are few studies using myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) which is considered as functional imaging [14,15]. MPI SPECT provides the advantage of using a different hemodynamic pathophysiological concept with microvascular perfusion assessment in CAD diagnosis as compared to other cardiac structural imaging methods such as invasive coronary angiography and CTA [16,17]. Therefore, this study was designed to evaluate the relationship between perfusion abnormalities of MPI SPECT with thyroid function in suspected CAD patients.…”