An efficient, one-pot synthetic protocol toward spirooxindole derivatives containing 1,4-dihydropyridine-fused 1,3-diazaheterocycle fragments, a class of biologically active compounds starting from 1,1-bis(methylthio)-2-nitroethylene, 1,n-diamine, isatin, or its derivatives, and malononitrile is described. The reaction proceeds in ethanol in the presence of 10 mol% of piperidine as a basic catalyst under reflux conditions to produce the title compounds in 74-85% yields.
A new Tc-99m N-doped Graphene Quantum Dot 99mTc-(N-GQDs) moiety, was developed (99mTc-N-GQDs) as a radiolabeling agents to molecules lacking chelation or water solubility of ligands simultaneously. (N-GQDs) were synthesized and...
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