Evaluating the Biostability of Yellow and Clear Intraocular Lenses with a System Simulating Natural Intraocular Environment

Abstract

PurposeBlue light–filtering intraocular lenses (IOLs) are thought to protect the retina from blue light damage after cataract surgery, and the implantation of yellow-tinted IOLs has been commonly used in cataract surgery. To our knowledge, this is the first investigation measuring the long-term biostability of yellow-tinted IOLs using an in vitro system simulating natural intraocular environment.MethodsSix hydrophobic acrylic IOLs, three clear IOLs, and three yellow-tinted IOLs were included in the study. Each yellow-tinted IOL was a matching counterpart of a clear IOL, with the only difference being the lens color. The IOLs were kept in conditions replicating the intraocular environment using a perfusion culture system for 7 months. Resolution, light transmittance rate, and the modulation transfer function (MTF) were measured before and after culturing. Surface roughness of the anterior and posterior surfaces was also measured.ResultsAfter culturing for 7 months, there were no changes in the resolution, the light transmittance rate, and MTF. The surface roughness of the anterior and posterior surfaces increased after culturing; however, this increase was clinically insignificant. There were no differences in surface roughness between the clear and yellow-tinted IOLs, either before or after culturing.ConclusionsA novel in vitro system replicating intraocular environment was used to investigate the biostability of yellow-tinted IOLs. The surface roughness showed no clinically significant increase after culturing for 7 months.Translational RelevanceThis system is useful for evaluating the biostability of IOLs.

Measurement of Force Required for Anterior Displacement of Intraocular Lenses and Its Defining Parameters

“…Materials 2020, 13, x 2 of 10 effect [8,[10][11][12][13]. Cataract surgery involving the implantation of clear IOLs has increased light transmittance at approximately 410 nm that might be associated with the risk of age-related macular degeneration [14]. To minimize this, yellow-tinted IOLs that absorb blue light are available [3,[14][15][16][17][18][19].…”

“…Cataract surgery involving the implantation of clear IOLs has increased light transmittance at approximately 410 nm that might be associated with the risk of age-related macular degeneration [ 14 ]. To minimize this, yellow-tinted IOLs that absorb blue light are available [ 3 , 14 , 15 , 16 , 17 , 18 , 19 ]. A bulky haptic, such as those of the foldable one-piece IOLs can hamper capsular bend formation and adhesion [ 13 , 20 , 21 , 22 , 23 ].…”

“…Accordingly, current one-piece soft-acrylic IOLs have adopted the sharp-edge design to achieve a sharper capsular Materials 2020, 13, 4593 2 of 10 bend, prompt capsular adhesion, and a greater PCO preventive effect [8,[10][11][12][13]. Cataract surgery involving the implantation of clear IOLs has increased light transmittance at approximately 410 nm that might be associated with the risk of age-related macular degeneration [14]. To minimize this, yellow-tinted IOLs that absorb blue light are available [3,[14][15][16][17][18][19].…”

Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management

“…Also, most of the AH and VH secreted into the eye consist of water containing small amounts of various substances (Table ). , AH and VH contain various ions, as well as various metabolites such as glucose, cholesterol, amino acids, proteins, oxygen, and carbon dioxide. AH, VH, and tears have similar components, but with slight differences.…”