Evaluating the biological potential of some new cobalt (II) complexes with acrylate and benzimidazole derivatives

Abstract

This paper presents the synthesis, physico‐chemical and biological properties of four new coordination compounds with mixed ligands: acrylate ion (acr) and benzimidazole/benzimidazole derivatives with the general formula [Co(L)2(acr)2]·nH2O [(1) L: benzimidazole (HBzIm), n: 0.5; (2) L: 2‐methylbenzimidazole (2‐MeBzIm), n: 0.5; (3) L: 5‐methylbenzimidazole (5‐MeBzIm), n: 0; (4) L: 5,6‐dimethylbenzimidazole (5,6‐Me2BzIm), n: 0]. Their chemical formulae were achieved correlating the chemical analysis with mass spectrometry data, the ligands coordination modes were assigned by Fourier transform‐infrared measurements, and the trigonal bipyramidal geometry of cobalt ion in complexes was assigned by data correlation of UV–Vis‐NIR spectra and magnetic moments measurements. Single‐crystal X‐ray diffraction reveals a mononuclear structure with a pentacoordinated cobalt (II) ion, connected to two acrylato coordinated in different modes and two unidentate 5,6‐dimethylbenzimidazole ligands for compound (4). The biological tests were performed against several microbial strains, the cytotoxicity was evaluated on HCT8 cellular lines and the cell cycle analysis was performed on HT29 cellular lines. Microbiological assays indicated that Co (II) complexes present a very good to good activity against Candida albicans 1760, Enterococcus faecium E5, Bacillus subtilis ATCC 6683 and Escherichia coli ATCC 25922. Predictive pharmacokinetic (ADME), toxicity and drug‐likeness profiles were evaluated for Co (II) complexes. Our results highlight that Co (II) complexes depicted in the present study are suitable to be used as efficient pharmacological agents.

Copper(II) Complexes with Mixed Heterocycle Ligands as Promising Antibacterial and Antitumor Species

“…The assessment of the complexes’ influence on the microbial ability to colonize an inert substratum with the establishment of the minimal biofilm eradication concentration (MBEC) was performed by the micro-titer method, following previously described protocols [ 51 ]. The absorbance at 490 nm was measured with an Apollo LB 911ELISA (Berthold Technologies GmbH & Co. KG, Waltham, MA, USA) reader.…”

Cobalt(II) Benzazole Derivative Complexes: Synthesis, Characterization, Antibacterial and Synergistic Activity

“…The antibacterial activity of the complexes 1 – 3 may be influenced by the presence of different heteroatoms in the benzazole ring. The MIC values of the complexes 2 and 3 were low against S. aureus and B. subtilis in comparison to the cobalt complexes reported in the literature . Therefore, the complexes 1 – 3 may be considered as promising potential antibacterial agents.…”

“…Transition metal complexes have extensive applications in different areas of chemistry and display significant antibacterial activities against a variety of bacteria including S. aureus . The synthesis of bioactive metal complexes with biologically active ligands and the evaluation of their biological activity are the subjects of current emerging research interest . Transition metal complexes are useful therapeutic agents that offer great diversity in their actions.…”

New Cobalt (II) Complexes with Imidazole Derivatives: Antimicrobial Efficiency against Planktonic and Adherent Microbes and In Vitro Cytotoxicity Features

“…As a continuation of our previous work on metal carboxylates with azole type ligands [ 6 , 18 , 19 , 20 , 21 ], we report herein the synthesis, structural characterization, and results related to biological activity for three novel complexes of the type [Co(C 4 H 5 O 2 ) 2 L 2 ] (C 4 H 5 O 2 = methacrylate anion (Macr); L = C 3 H 4 N 2 (imidazole; Im) ( 1 ), C 4 H 6 N 2 (2-methylimidazole; 2-MeIm) ( 2 ), C 5 H 8 N 2 (2-ethylimidazole; 2-EtIm) ( 3 ).…”

“…The tumor cells treated with 50 and 100 µg/mL cobalt complexes, for 72 h were harvested with trypsin, fixed in cold ethanol (70%), and stained with 50 µg/mL propidium iodide containing 100 µg/mL RNAse A Acquisition was performed using Beckman Coulter flowcytometer (Beckman Coulter, Nyon, Switzerland) and analyses was done using FlowJo software 7.2.5. (Ashland, CA, USA) [ 21 , 32 ].…”