Cobalt(II) Benzazole Derivative Complexes: Synthesis, Characterization, Antibacterial and Synergistic Activity

Nandanwar, Sondavid K.; Borkar, Shweta; Wijaya, Bryan Nathanael; Cho, Joung Hyung; Tarte, Naresh Hiralal; Kim, Soo Hyun

doi:10.1002/slct.202000222

Cited by 6 publications

(8 citation statements)

References 43 publications

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“…To assess the effectiveness of NP-R against these bacterial strains, we determined the Minimal Inhibitory Concentration (MIC) following protocol outlined in our previous report. 23 …”

Section: Methodsmentioning

confidence: 99%

Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts

Tran,

Hoang,

Nandanwar

et al. 2023

RSC Adv.

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“…To assess the effectiveness of NP-R against these bacterial strains, we determined the Minimal Inhibitory Concentration (MIC) following protocol outlined in our previous report. 23 …”

Section: Methodsmentioning

confidence: 99%

Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts

Tran,

Hoang,

Nandanwar

et al. 2023

RSC Adv.

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“…To evaluate the efficacy of NI-Cz against these bacterial strains, the MIC was determined using the protocol outlined in our previous report. 45 For PDT treatment, a sample comprising bacteria and NI-Cz was prepared. The concentration of NI-Cz in the sample ranged from 250 to 1.95 μg/ mL.…”

Section: ■ Conclusionmentioning

confidence: 99%

Imidazolium-Based Heavy-Atom-Free Photosensitizer for Nucleus-Targeted Fluorescence Bioimaging and Photodynamic Therapy

Pham,

Hoang,

Tran

et al. 2023

ACS Appl. Mater. Interfaces

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The development of heavy-atom-free photosensitizers (PSs) for photodynamic therapy (PDT) has encountered significant challenges in achieving simultaneous high fluorescence emission and reactive oxygen species (ROS) generation. Moreover, the limited water solubility of these PSs imposes further limitations on their biomedical applications. To overcome these obstacles, this study presents a molecular design strategy employing hydrophilic heavy-atom-free PSs based on imidazolium salts. The photophysical properties of these PSs were comprehensively investigated through a combination of experimental and theoretical analyses. Notably, among the synthesized PSs, the ethylcarbazole-naphthoimidazolium (NI-Cz) conjugate exhibited efficient fluorescence emission (Φ F = 0.22) and generation of singlet oxygen (Φ Δ = 0.49), even in highly aqueous environments. The performance of NI-Cz was validated through its application in fluorescence bioimaging and PDT treatment in HeLa cells. Furthermore, NI-Cz holds promise for two-photon excitation and type I ROS generation, nucleus localization, and selective activity against Gram-positive bacteria, thereby expanding its scope for the design of heavy-atom-free PSs and phototheranostic applications.

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“…Figure 2. Structure of antibacterial copper complexes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)14) of ligands (i-vii) [53][54][55][56] stoichiometric ratio [17] . Synthesized compounds were well characterized by its elemental analysis, magnetic measurement and other physiochemical techniques.…”

Section: Antibacterial Activity Of Bi-nuclear Copper Complexesmentioning

confidence: 99%

“…general microbial infections, diabetes, inflammation, cancer, acquired immune deficiency syndrome, Alzheimer, Parkinson etc. Among various therapeutic potentials, antimicrobial applications of metal complexes are the centre of attention for medicinal chemists due to resistance of pathogenic microbes against traditional antibiotics developed from organic synthons [8][9][10] . Copper was known well for its anti-microbial as well as therapeutic properties from a very long time [11] .…”

Section: Introductionmentioning

confidence: 99%

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion: A Mini Review

Srivastva

Saxena

Singh

et al. 2022

j. of met. mater. res.

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Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory, gastrointestinal and central nervoussystem account for the majority of cases of sudden casualties. Readily availabledrugs are getting ineffective by each passing day as the mutation is veryfast in these pathogenic microbes resulting in drug resistance. The growingresistance of bacteria necessitates the development of new and effectivecompounds of desired characteristics that could bar the rapid development ofbacterial cell inside of the host body. Along with cellular resistance for clinicalantibiotics, co-bacterial infections during microbial attacks (viz. virus, fungus,protozoans etc.) also demand for some novel antibacterial drugs having highefficacy and minimal side effects on human body. These antibiotics shouldalso be compatible with remedies ongoing for core microbial infections. So,in demand of search for effective antibacterial moieties, the scope of transitionmetal complexes as drug gives a good signal against the pathogenic bacteriaby inhibiting their growth. The action of metal complexes on bacterial cellmay be due to impremiablity, enzymatic interruptions, ribosomal interactions,disturbance in the path of protein synthesis, denaturing of genetic materialsetc. inside the cell. Metals in complexes may interrupt the lipophilisity throughthe bacterial cell wall. Inclusion of metal ions in organic moieties behavingas ligand delocalize π-electrons upon the entire chelate ring and this chelationresults in overlapping of ligand orbital and partial sharing of (+)ve chargeof metal ion with donor atoms. These structural modifications in metal andorganic lone pair donor species are the supposed reasons for their enhancedantimicrobial activities against pathogenic microbes. The present reviewfocuses on the impact of recently synthesized, well characterized mono andbinuclear transition metal complexes of Cu ions that have the potential to be the drug of the decade in medicinal inorganic chemistry for treating the bacterial diseases.

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Cobalt(II) Benzazole Derivative Complexes: Synthesis, Characterization, Antibacterial and Synergistic Activity

Cited by 6 publications

References 43 publications

Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts

Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts

Imidazolium-Based Heavy-Atom-Free Photosensitizer for Nucleus-Targeted Fluorescence Bioimaging and Photodynamic Therapy

Anti-bacterial Properties of Transition Metal Complexes of Copper Metal Ion: A Mini Review

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