Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts

Abstract

Molecular design and synthesis toward two-photon-excited and lysosome-targeted fluorescent naphthoimidazolium salts with anticancer and antibacterial activity.

Charge Transfer-Promoted Excited State of a Heavy-Atom-Free Photosensitizer for Efficient Application of Mitochondria-Targeted Fluorescence Imaging and Hypoxia Photodynamic Therapy

“…In addition to this, the two-photon absorption properties of Cz-SB were computed, revealing a substantial value (δ TPA = 71.1 GM) at 954 nm; see computational details. This notable characteristic enhances its potential application in fluorescence imaging and PDT treatment under near-infrared two-photon light excitation. , Subsequently, molecular geometry optimization of the first excited state (S 1 ) and determination of fluorescence emission properties were undertaken through Tamm–Dancoff TD-DFT calculations (i.e., TDA-DFT) in acetonitrile (Table ). The emission properties predominantly arise from the LUMO → HOMO transition, which fundamentally corresponds to a 1 π–π* transition.…”