Evaluating the Association between Insulin-Like Growth Factor-1 Values and Short-Term Survival Rates following Acute Myocardial Infarction

Abstract

Backgrounds:In recent years, low levels of Insulin-like Growth Factor-1 (IGF-1) have been suggested to be associated with higher risks of developing heart failure and higher long-term mortality rates following Acute Myocardial Infarction (AMI). However, the effect of IGF-1 levels on short-term survival has been rarely studied. In this study we aimed to assess any possible association between serum IGF-1 concentration following AMI and short-term survival rates.Methods:In this study, serum total IGF-1 levels were measured in 56 patients within 24 hours following AMI and were compared to 56 individuals with no cardiovascular disease. Patients were followed up to death or discharge from hospital (median = 6 days) and survival curves were compared based on median IGF-1 value.Results:Mean (±SD) of serum IGF-1 levels were 232.73 ng/ml (±81.74) and 211.00 ng/ml (±58.22) in survived and expired patients respectively and the difference was not statistically significant (P value = 0.501). The difference between survival curves was also not statistically significant (P value = 0.246).Conclusion:According to findings of this study, serum total IGF-1 concentration does not seem to be associated with short-term survival rates.

Serum IGF-1 düzeyleri akut miyokard infarktüsü sonrası gerçekten azalır mı ve sol ventrikül disfonksiyonu ile ilişkili midir?

“…The evaluation of in-hospital events (arrhythmia, ischemia, and heart failure) revealed that the patients, who developed complications, had lower levels of IGF-1 and IGFBP-3; however, the differences were not statistically significant (p=0,1). In earlier studies, low IGF-1 levels and major cardiac events were found to be associated (13)(14)(15)(16)(17)25). In our study, no major cardiac events were observed; thus, their relationship with the IGF-1 level could not be evaluated.…”

“…Unfortunately, a control group was not used, and obese and diabetic elderly patients with heart failure were included in this study. Similarly, Hajsadeghi et al (15) showed that IGF-1 levels in the first 24 hours following AMI were found to be lower in the comparison with the control group.…”

“…On the other hand, the results from a few studies that examined the association between the IGF-1/ IGFBP-3 levels and the early post AMI period were controversial. In almost all studies, levels of IGF-1 were lower or did not change in the setting of AMI (12)(13)(14)(15). For example, Friberg et al (13) investigated the serum IGF-1 levels on a small number of AMI patients.…”

“…They demonstrated that IGF-1 levels were lowered by the 7.th day of MI then IGF-1 levels were returned the previous levels. Hajsadeghi et al (15) indicated that IGF-1 levels in the first 24 hours following AMI were found to be lower in comparison with the control group, and the serum total IGF-1 concentration did not seem to be associated with short-term survival (15). The evaluation of in-hospital events (arrhythmia, ischemia, and heart failure) revealed that the patients, who developed complications, had lower levels of IGF-1 and IGFBP-3; however, the differences were not statistically significant (p=0,1).…”

The impact of circulating IGF-1 and IGFBP-2 on cardiovascular prognosis in patients with acute coronary syndrome

“…IGF-1 levels were previously found to be lower in acute MI patients compared to healthy controls (24,25). To date, however, studies evaluating the influence of IGFBP-2 levels on cardiovascular disease remain scarce.…”