Insulin-Like Growth Factor 1 in the Cardiovascular System

Aguirre, Gabriel A.; González-Guerra, José Luis; Espinosa, Luís; Castilla‐Cortázar, Inma

doi:10.1007/112_2017_8

Cited by 24 publications

(23 citation statements)

References 242 publications

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“…According to Aguirre et al, at the initiation of metabolic dysregulation by overfeeding, IGF-1 is decreased. Such defi ciency seems to be related to the onset of MS and atherosclerosis (19). In agreement with these previous data, our study confi rmed that IGF-1 is inversely related to metabolic parameters of carbohydrates and lipids, suggesting its protective role in the metabolic syndrome associated with PCOS.…”

supporting

confidence: 91%

Insulin-like growth factor (IGF) system and hormonal-metabolic profile in women with polycystic ovary syndrome

Lazúrová¹,

Figurová²,

Lazurova³

et al. 2021

BLL

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AIM of the study was to compare serum levels of IGF-1, IGF-2 and insulin-like growth factor-binding protein 3 (IGFBP-3) among non-obese and obese PCOS women, and to assess their relationship to metabolic and hormonal parameters. METHODS: The study included 64 women diagnosed with PCOS (age 28.9 ± 5 years); 30 of them with BMI > 27 and 34 with BMI lower than 27. All subjects were examined for parameters of glucose and lipid metabolism, steroid hormones and serum IGF-1, IGF-2 and IGFBP-3 levels. RESULTS: No signifi cant differences in serum IGFBP-3 (p=0.534), IGF-1 (p=0.29) and IGF-2 (p=0.56) between two groups have been detected. IGFBP-3 was in positive correlation with total cholesterol (p=0.026), LDL cholesterol (p=0.03) and triacylglycerols (p=0.022). IGF-1 were negatively correlated with insulin (p=0.022), HOMA IR (p=0.033), triacylglycerols (p=0.0196) and waist circumference (p=0.049). A positive correlation was detected between IGF-1 and HDL cholesterol (p=0.025). No signifi cant relationship was observed between IGF-1 and steroid hormones. CONCLUSION: Serum levels of IGF-1, IGF-2 and IGFBP-3 in obese PCOS women do not differ from those detected in non-obese PCOS women. IGF-1 negatively correlated with metabolic parameters, indicating that lower IGF-1 may represent an important predictor of metabolic syndrome (MS) in PCOS women. All peptides seem to have little effect on ovarian steroidogenesis in PCOS (Tab. 1, Fig. 1, Ref. 30).

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supporting

confidence: 91%

Insulin-like growth factor (IGF) system and hormonal-metabolic profile in women with polycystic ovary syndrome

Lazúrová¹,

Figurová²,

Lazurova³

et al. 2021

BLL

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“…Insulin-like growth factor 1 (IGF-1) has a vital function in maintaining the structure and function of the body ( 15 , 16 ). Recently, IGF-1 was revealed to be closely associated with the development and growth of cardiomyocytes by promoting cell growth and resisting cell death ( 17 ). Therefore, the secretion of IGF-1 by MSCs may be an effective strategy to retard myocardial I/R injury.…”

Section: Introductionmentioning

confidence: 99%

The Exosomal lncRNA KLF3-AS1 From Ischemic Cardiomyocytes Mediates IGF-1 Secretion by MSCs to Rescue Myocardial Ischemia-Reperfusion Injury

Chen

Yue

Wang

et al. 2021

Front. Cardiovasc. Med.

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The purpose of the study was to explore the mechanism by which myocardial ischemia-reperfusion (I/R) injury-induced exosomes modulate mesenchymal stem cells (MSCs) to regulate myocardial injury. In this study, we established an I/R injury model in vivo and a hypoxia-reoxygenation (H/R) model in vitro. Then, exosomes isolated from H/R-exposed H9c2 cells were characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blot analysis. CCK-8 assays and flow cytometry were performed to assess cell injury. ELISA was applied to determine the level of insulin-like growth factor 1 (IGF-1). Echocardiography was used to assess cardiac function in vivo. HE staining and TUNEL assays were conducted to analyze myocardial injury in vivo. In the present study, H/R-exposed H9c2 cells induced IGF-1 secretion from MSCs to inhibit cell myocardial injury. Moreover, exosomes derived from H/R-exposed H9c2 cells were introduced to MSCs to increase IGF-1 levels. The lncRNA KLF3-AS1 was dramatically upregulated in exosomes derived from H/R-treated H9c2 cells. Functional experiments showed that the exosomal lncRNA KLF3-AS1 promoted IGF-1 secretion from MSCs and increased H9c2 cell viability. In addition, miR-23c contains potential binding sites for both KLF3-AS1 and STAT5B, and miR-23c directly bound to the 3'-UTRs of KLF3-AS1 and STAT5B. Furthermore, the lncRNA KLF3-AS1 promoted IGF-1 secretion from MSCs and rescued myocardial cell injury in vivo and in vitro by upregulating STAT5B expression. The lncRNA KLF3-AS1 may serve as a new direction for the treatment of myocardial I/R injury.

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“…For this reason, IGF-1 deficiency has a central role in this whole process, as it is one of the most potent antiapoptotic, antioxidant and cytoprotective factors known today. Moreover, IGF-1 is also known to have vasodilator actions [19]. IGF-1 regulates cell proliferation, apoptosis, migration and differentiation, so it is a potent mitogen factor for vascular smooth cells to stimulate migration and antiapoptotic effects of VSMC [20].…”

Section: Discussionmentioning

confidence: 99%

Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study

Taşar

Kocabay

Karabağ

et al. 2020

pwki

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Introduction: Periprocedural myocardial necrosis, which can range from a low level elevation of cardiac biomarkers to a large myocardial infarction (MI), is a common complication after percutaneous coronary intervention (PCI). Aim: We hypothesized that insulin-like growth factor-1 (IGF-1) levels may play a protective role in myocardial injury after coronary stent placement and aimed to investigate the relationship between IGF-1 levels and plaque characteristics assessed by optical coherence tomography (OCT). Material and methods: Between May 2015 and December 2015 we prospectively enrolled 74 patients with stable angina pectoris in whom single de novo coronary artery stenosis was present. PCI was performed according to standard methods. OCT was applied to all patients. TnT was analyzed at admission, before PCI and at 6, 12, 24 and 48 h after PCI. Serum IGF-1 was measured prior to PCI. Results: A total of 25 (33.7%) patients had periprocedural myocardial injury or type 4a myocardial infarction, and 49 (66.2%) patients had no events. IGF-1 level and reference intimal thickness, medial thickness, and plaque fibrous cap thickness in OCT had strong correlations (r = 0.88, 0.80 and 0.88 respectively, p < 0.001). IGF-1 was an independent predictor of periprocedural myocardial injury or type 4a MI in univariate (OR = 0.929, 95% CI: 0.895-0.964, p < 0.001) and multivariate regression analysis (OR = 0.757, 95% CI: 0.575-0.998, p = 0.04). Based on ROC analysis, the best cutoff value of IGF-1 for predicting periprocedural myocardial injury or type 4a myocardial infarction was 144.5 ng/ml, with a maximum sensitivity of 88% and specificity of 77.6% (AUC = 0.80, 95% CI: 0.69-0.88, p < 0.0001). Conclusions: The results from this study indicate that low IGF-1 levels are associated with plaque instability assessed by OCT. Low IGF-1 levels may identify patients who are at increased risk for periprocedural myocardial injury/infarction.

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Insulin-Like Growth Factor 1 in the Cardiovascular System

Cited by 24 publications

References 242 publications

Insulin-like growth factor (IGF) system and hormonal-metabolic profile in women with polycystic ovary syndrome

Insulin-like growth factor (IGF) system and hormonal-metabolic profile in women with polycystic ovary syndrome

The Exosomal lncRNA KLF3-AS1 From Ischemic Cardiomyocytes Mediates IGF-1 Secretion by MSCs to Rescue Myocardial Ischemia-Reperfusion Injury

Insulin-like growth factor-1 levels predict myocardial injury and infarction after elective percutaneous coronary intervention: an optical coherence tomography study

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