Evaluating the antimicrobial activity and cytotoxicity of polydopamine capped silver and silver/polydopamine core-shell nanocomposites

Shumbula, Ndivhuwo P.; Nkabinde, Siyabonga S.; Ndala, Zakhele B.; Mpelane, Siyasanga; Shumbula, Morgan P.; Mdluli, Phumlane Selby; Njengele-Tetyana, Zikhona; Tetyana, Phumlani; Hlatshwayo, Thulani Thokozani; Mlambo, Mbuso; Moloto, Nosipho

doi:10.1016/j.arabjc.2022.103798

Cited by 19 publications

(27 citation statements)

References 43 publications

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“…The primary mechanism that Ag NPs follow to inhibit bacteria is still not completely clear because it does not attack them through a single pathway. However, microorganisms do not seem to acquire resistance against silver [ 97 ]. The antimicrobial action of Ag NPs is linked to four well-defined mechanisms: (1) the adhesion of the nanoparticles to the surface of the cell membrane and wall; (2) the penetration of the NPs into the cell-damaging intracellular structures and biomolecules; (3) the NP-induced cellular toxicity and oxidative stress caused by the reactive oxygen species (ROS) and free radicals produced; and (4) the modulation of the signaling pathways related to cell transduction [ 98 ].…”

Section: Discussionmentioning

confidence: 99%

Green Synthesis via Eucalyptus globulus L. Extract of Ag-TiO2 Catalyst: Antimicrobial Activity Evaluation toward Water Disinfection Process

et al. 2022

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The problem of water pollution by persistent substances and microorganisms requires solutions that materials such as silver-modified titanium dioxide can provide due to their excellent photocatalytic and antimicrobial properties. However, the synthesis methods conventionally used to obtain these materials involve toxic chemical reagents such as sodium borohydride (NaBH4). The search for alternative synthesis methods that use environmentally friendly substances, such as the biosynthesis method, was evaluated. Silver-titanium dioxide (Ag-TiO2) was synthesized by a Eucalyptus globulus L. extract as a reductive agent through sol-gel and microwave-assisted sol-gel processes. Four different solvents were tested to extract secondary metabolites to determine their roles in reducing silver nanoparticles. Titanium dioxide nanoparticles with sizes from 11 to 14 nm were obtained in the anatase phase, and no narrowing of the bandgap was observed (3.1–3.2 eV) for the Ag-TiO2 materials compared with the pure TiO2. Interestingly, the bacterial inhibition values were close to 100%, suggesting an effective antimicrobial mechanism related to the properties of silver. Finally, by the physicochemical characterization of the materials and their antimicrobial properties, it was possible to obtain a suitable biosynthesized Ag-TiO2 material as a green option for water disinfection that may be compared to the conventional methods.

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Section: Discussionmentioning

confidence: 99%

Green Synthesis via Eucalyptus globulus L. Extract of Ag-TiO2 Catalyst: Antimicrobial Activity Evaluation toward Water Disinfection Process

et al. 2022

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“…Metal nanoparticles are potential environmental hazards and difficult to recover or deactivate in solid-waste incineration plants or wastewater treatment systems [ 184 , 185 , 186 ]. To overcome the above limitations, metal nanoparticles could be incorporated into other nanomaterials to form nanocomposites, which show a greater dispersion of metal nanoparticles, improved antibacterial activity, and reduced toxicity [ 187 , 188 , 189 ]. This will be further discussed in Section 4 below.…”

Section: Antibacterial Inorganic Nanomaterialsmentioning

confidence: 99%

“…Polymer–metal composite nanoparticles could potentially solve the environmental hazards associated with many metal nanoparticles. Richter et al postulated that a metallic core is not necessary for the antimicrobial action [ 187 ]. Instead of synthesizing the entire nanoparticle of metal, the composite nanoparticle can be produced by infusion with a minimum amount of silver ions to the biodegradable lignin core, followed by surface functionalization with a layer of cationic polyelectrolyte [ 187 ].…”

Section: Nanocomposite/nanohybrid Antibacterial Materialsmentioning

confidence: 99%

“…Richter et al postulated that a metallic core is not necessary for the antimicrobial action [ 187 ]. Instead of synthesizing the entire nanoparticle of metal, the composite nanoparticle can be produced by infusion with a minimum amount of silver ions to the biodegradable lignin core, followed by surface functionalization with a layer of cationic polyelectrolyte [ 187 ]. The resulting composite nanoparticles exhibited broad-spectrum bactericidal activity against E. coli , P. aeruginosa, and a quaternary-amine-resistant Ralstonia .…”

Section: Nanocomposite/nanohybrid Antibacterial Materialsmentioning

confidence: 99%

“…The required silver ions were ten times lesser than when using conventional silver nanoparticles. The gradual diffusion of silver ions from the silver-infused lignin core composite nanoparticles into water will rapidly lose their post-utilization activity and be biodegradable in the environment after disposal [ 187 ].…”

Section: Nanocomposite/nanohybrid Antibacterial Materialsmentioning

confidence: 99%

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Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications

Ren

Lim

et al. 2022

Nanomaterials

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Infections caused by multidrug-resistant (MDR) bacteria are becoming a serious threat to public health worldwide. With an ever-reducing pipeline of last-resort drugs further complicating the current dire situation arising due to antibiotic resistance, there has never been a greater urgency to attempt to discover potential new antibiotics. The use of nanotechnology, encompassing a broad range of organic and inorganic nanomaterials, offers promising solutions. Organic nanomaterials, including lipid-, polymer-, and carbon-based nanomaterials, have inherent antibacterial activity or can act as nanocarriers in delivering antibacterial agents. Nanocarriers, owing to the protection and enhanced bioavailability of the encapsulated drugs, have the ability to enable an increased concentration of a drug to be delivered to an infected site and reduce the associated toxicity elsewhere. On the other hand, inorganic metal-based nanomaterials exhibit multivalent antibacterial mechanisms that combat MDR bacteria effectively and reduce the occurrence of bacterial resistance. These nanomaterials have great potential for the prevention and treatment of MDR bacterial infection. Recent advances in the field of nanotechnology are enabling researchers to utilize nanomaterial building blocks in intriguing ways to create multi-functional nanocomposite materials. These nanocomposite materials, formed by lipid-, polymer-, carbon-, and metal-based nanomaterial building blocks, have opened a new avenue for researchers due to the unprecedented physiochemical properties and enhanced antibacterial activities being observed when compared to their mono-constituent parts. This review covers the latest advances of nanotechnologies used in the design and development of nano- and nanocomposite materials to fight MDR bacteria with different purposes. Our aim is to discuss and summarize these recently established nanomaterials and the respective nanocomposites, their current application, and challenges for use in applications treating MDR bacteria. In addition, we discuss the prospects for antimicrobial nanomaterials and look forward to further develop these materials, emphasizing their potential for clinical translation.

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Polydopamine‐Enabled Biomimetic Surface Engineering of Materials: New Insights and Promising Applications

Saraf,

Prateek,

Ranjan

et al. 2023

Adv Materials Inter

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Surface modification is an important approach to modify the properties of materials. Numerous approaches have been adopted to tailor the properties of such materials, which have been proven successful at many scales and parameters. However, most of these techniques are often tedious, poorly adhesive, costly, sometimes hazardous, and surface‐specific, hence cannot be extended on a large scale and all kinds of surfaces. These shortcomings have led to the emergence of new dopamine (DA) based green surface modification technique where a thin polydopamine (PDA) layer is deposited on surfaces through a facile polymerization of DA under alkaline conditions to enable the surface for various applications. This surface modification strategy has several advantages over other techniques in deposition processing under mild conditions, cost‐effective and straightforward ingredients, and applicability to all kinds of surfaces regardless of their sizes, shapes, and types. Moreover, the PDA layer enhances the surface functionality. Therefore, it can serve as a versatile platform for various secondary reactions for a wide range of applications. Herein, the chemistry of DA is summarized and its polymerized form PDA for the modification of different families of materials’ surfaces with an emphasis on energy, environmental and biological applications.

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Evaluating the antimicrobial activity and cytotoxicity of polydopamine capped silver and silver/polydopamine core-shell nanocomposites

Cited by 19 publications

References 43 publications

Green Synthesis via Eucalyptus globulus L. Extract of Ag-TiO2 Catalyst: Antimicrobial Activity Evaluation toward Water Disinfection Process

Green Synthesis via Eucalyptus globulus L. Extract of Ag-TiO2 Catalyst: Antimicrobial Activity Evaluation toward Water Disinfection Process

Recent Advances in the Development of Lipid-, Metal-, Carbon-, and Polymer-Based Nanomaterials for Antibacterial Applications

Polydopamine‐Enabled Biomimetic Surface Engineering of Materials: New Insights and Promising Applications

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