Evaluating Phospholipid‐Functionalized Gold Nanorods for In Vivo Applications

Roach, Lucien; Booth, Mary E.; Ingram, Nicola; Paterson, Daniel A.; Batchelor, Damien V. B.; Moorcroft, Samuel C T; Bushby, Richard J.; Critchley, Kevin; Coletta, P. Louise; Evans, Stephen D.

doi:10.1002/smll.202006797

Cited by 15 publications

(7 citation statements)

References 78 publications

(141 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Further, the surface of AuNRs can bind specific antibodies, targeting peptides, phospholipids, and nucleic acids, such as DNA, small interfering RNA (siRNA), or small molecule drugs, which could improve the biological targeting of AuNRs [ 58 , 59 ]. AuNRs-PDGFRβ formed by coupling AuNRs-PEG with anti-PDGFRβ antibody can precisely target the PDGFβ receptor on the surface of hepatic stellate cells, exerting an anti-hepatic fibrosis effect (Fig.…”

Section: Functionalized Aunrs Photothermal Agentsmentioning

confidence: 99%

Gold Nanorods-Based Photothermal Therapy: Interactions Between Biostructure, Nanomaterial, and Near-Infrared Irradiation

Zhou

Zhang

et al. 2022

Nanoscale Res Lett

View full text Add to dashboard Cite

Gold nanorods (AuNRs) are ideal inorganic nanophotothermal agents with unique characteristics, including local surface plasmon resonance effects, easy scale preparation and functional modification, and good biocompatibility. This review summarizes several recent advances in AuNRs-based photothermal therapy (PTT) research. Functionalized AuNRs photothermal agents have optimized biocompatibility and targeting properties. The multifunctional AuNRs nanoplatform composite structure meets the requirements for synergistic effects of PTT, photoacoustic imaging, and other therapeutic methods. Photothermal therapy with AuNRs (AuNRs-PTT) is widely used to treat tumors and inflammatory diseases; its tumor-targeting, tumor metastasis inhibition, and photothermal tumor ablation abilities have remarkable curative effects. An in-depth study of AuNRs in living systems and the interactions between biological structure, nanomaterial, and near-infrared irradiation could lay the foundation for further clinical research and the broad application of AuNRs in PTT.

show abstract

Section: Functionalized Aunrs Photothermal Agentsmentioning

confidence: 99%

Gold Nanorods-Based Photothermal Therapy: Interactions Between Biostructure, Nanomaterial, and Near-Infrared Irradiation

Zhou

Zhang

et al. 2022

Nanoscale Res Lett

View full text Add to dashboard Cite

show abstract

“…Recently, the phospholipids functionalized gold nanorods are used for in-vivo imaging applications. Here the CTAB is replaced with other series of phospholipids such as DOPC (Di-palmitoyl phosphatidylcholine) and DSPE (Di-stearoyl phosphoryl ethanolamine) [100]. The surfactant displacement can achieve through sonication and purification using centrifugation.…”

Section: One Dimensional (1d) Nanomaterials In Theranosismentioning

confidence: 99%

Nanomaterials: Synthesis and Applications in Theranostics

et al. 2021

View full text Add to dashboard Cite

Nanomaterials are endowed with unique features and essential properties suitable for employing in the field of nanomedicine. The nanomaterials can be classified as 0D, 1D, 2D, and 3D based on their dimensions. The nanomaterials can be malleable and ductile and they can be drawn into wires and sheets. Examples of nanomaterials are quantum dots (0D), nanorods, nanowires (1D), nanosheets (2D), and nanocubes (3D). These nanomaterials can be synthesized using top-down and bottom-up approaches. The achievements of 0D and 1D nanomaterials are used to detect trace heavy metal (e.g., Pb2+) and have higher sensitivity with the order of five as compared to conventional sensors. The achievements of 2D and 3D nanomaterials are used as diagnostic and therapeutic agents with multifunctional ability in imaging systems such as PET, SPECT, etc. These imaging modalities can be used to track the drug in living tissues. This review comprises the state-of-the-art of the different dimensions of the nanomaterials employed in theranostics. The nanomaterials with different dimensions have unique physicochemical properties that can be utilized for therapy and diagnosis. The multifunctional ability of the nanomaterials can have a distinct advantage that is used in the field of theranostics. Different dimensions of the nanomaterials would have more scope in the field of nanomedicine.

show abstract

“…Typical gold NT (Au NT) syntheses rely on the use of surfactants, such as cetyltrimethylammonium bromide or chloride (CTAB and CTAC, respectively), which adsorb preferentially on certain low Miller index planes, blocking them and inducing the anisotropic growth of the particles. − However, quaternary ammonium surfactants are known for their cytotoxic effect, − and some complex strategies have been reported in order to either remove CTAB or encapsulate it with a second layer. − Nevertheless, the use of these toxic surfactants should be directly avoided if NPs are to be synthesized for biomedical purposes. Moreover, most surfactant-driven syntheses rarely produce Au NTs that simultaneously satisfy NIR absorbance beyond 800 nm and dimensions smaller than 100 nm in edge length, which are desirable for in vivo applications. ,,, For these reasons, much effort is continuously being made by the scientific community to produce biocompatible Au NTs. ,, …”

Section: Introductionmentioning

confidence: 99%

Optimized Biocompatible Gold Nanotriangles with NIR Absorption for Photothermal Applications

Otero

Simal

Scocozza

et al. 2022

ACS Appl. Nano Mater.

View full text Add to dashboard Cite

Gold nanotriangles (Au NTs) present singular plasmonic properties that are particularly attractive for photothermal applications. However, most syntheses rely on the use of surfactants which present cytotoxic effects, thus limiting the biomedical possibilities. Moreover, these methods have the disadvantage of producing Au NTs that either present absorption at wavelengths <750 nm or have side lengths >200 nm. In this work, we present the post-synthesis optimization and characterization of biocompatible Au NTs produced in a one-step reduction of Au(III) with thiosulfate ions. We demonstrate that the position of the absorption peaks can be fixed at a desired wavelength by the addition of different SH-containing molecules. In all cases, the stabilized Au NTs can be efficiently separated from spherical gold nanoparticles, a byproduct of most Au NT syntheses, by a method based on depletion forces using sodium dodecyl sulphate (SDS), a low-cost, non-toxic surfactant. In addition, we analyze possible cytotoxic effects of surface sulfide species and residual presence of SDS. First, incubation of the Au NTs with H 2 S-binding hemoglobin I from Lucina pectinata produced no deleterious effect on the protein. Second, we evaluated cytocompatibility by in vitro cellular tests after incubation with the purified Au NTs. Finally, laser irradiation at 808 nm of the Au NT dispersions yields photothermal conversion efficiencies of around 50%, which remained constant after several heating cycles.

show abstract

Evaluating Phospholipid‐Functionalized Gold Nanorods for In Vivo Applications

Cited by 15 publications

References 78 publications

Gold Nanorods-Based Photothermal Therapy: Interactions Between Biostructure, Nanomaterial, and Near-Infrared Irradiation

Gold Nanorods-Based Photothermal Therapy: Interactions Between Biostructure, Nanomaterial, and Near-Infrared Irradiation

Nanomaterials: Synthesis and Applications in Theranostics

Optimized Biocompatible Gold Nanotriangles with NIR Absorption for Photothermal Applications

Contact Info

Product

Resources

About