Evaluating Localized Prostate Cancer and Identifying Candidates for Focal Therapy

Sartor, A. Oliver; Hricak, Hedvig; Wheeler, Thomas M.; Coleman, Jonathan; Penson, David F.; Carroll, Peter R.; Rubin, Mark A.; Scardino, Peter T.

doi:10.1016/j.urology.2008.10.004

Cited by 112 publications

(72 citation statements)

References 106 publications

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“…Consequently, a major clinical challenge is posed by the current inability to readily distinguish indolent from aggressive tumors in prostate cancer patients who present with low Gleason grade tumors upon biopsy (Sartor et al 2008). The absence of this prognostic information has led to a significant ''overtreatment'' of patients who would otherwise require only conservative management.…”

Section: Distinguishing Indolent Vs Aggressive Diseasementioning

confidence: 99%

Molecular genetics of prostate cancer: new prospects for old challenges

Shen¹,

2010

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Despite much recent progress, prostate cancer continues to represent a major cause of cancer-related mortality and morbidity in men. Since early studies on the role of the androgen receptor that led to the advent of androgen deprivation therapy in the 1940s, there has long been intensive interest in the basic mechanisms underlying prostate cancer initiation and progression, as well as the potential to target these processes for therapeutic intervention. Here, we present an overview of major themes in prostate cancer research, focusing on current knowledge of principal events in cancer initiation and progression. We discuss recent advances, including new insights into the mechanisms of castration resistance, identification of stem cells and tumor-initiating cells, and development of mouse models for preclinical evaluation of novel therapuetics. Overall, we highlight the tremendous research progress made in recent years, and underscore the challenges that lie ahead.

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Section: Distinguishing Indolent Vs Aggressive Diseasementioning

confidence: 99%

Molecular genetics of prostate cancer: new prospects for old challenges

Shen¹,

2010

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“…Despite recent progress, the major clinical challenges are to provide an effective means to stratify metastatic cancer from indolent tumors and to treat patients who have a deadly metastatic cancer (3). Thus, understanding the underlying mechanism by which indolent lesions give rise to metastatic cancer will likely benefit disease diagnosis and intervention.…”

Section: Introductionmentioning

confidence: 99%

AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis

Ni¹,

Xue²,

Yuan³

et al. 2017

Journal of Clinical Investigation

108

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“…15,32 The diffusion properties of a biological tissue are related to the amount of interstitial free water and permeability, reflecting tissue cellularity and the presence of intact cellular membranes. In general, cancer, abscesses, fibrosis, hemorrhage and cytotoxic edema may show restricted diffusion compared to than normal tissue, because of the high cellular density.…”

Section: Diffusion-weighted Imaging (Dwi)mentioning

confidence: 99%

“…The value of MRI on prostate cancer has however been extended to cases of recurrence suspicion, active surveillance, refused biopsy, MRI-guided biopsy, and also MRI-US fusion technology to improve the accuracy of USguided biopsies. 6,[10][11][12][13][14][15] Although morphological MRI including T1 and T2 weighted-imaging (WI) has been widely used for the pretreatment study of prostate cancer, this technique has some limitations and improvement in sensitivity and specificity for cancer detection and localization may be achieved in combination with functional techniques such as dynamic contrast-enhanced MR imaging (DCE), diffusionweighted imaging (DWI), and MR spectroscopy (MRS). The combination of T2WI with at least two of these techniques is known as multiparametric MRI (mp-MRI).…”

Section: Introductionmentioning

confidence: 99%

Prostate Cancer: The Role of Multiparametric Magnetic Resonance Imaging

et al. 2015

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Multiparametric Magnetic Resonance Imaging has been increasingly used for detection, localization and staging of prostate cancer over the last years. RESUMOA Ressonância Magnética Multiparamétrica tem sido crescentemente utilizada na detecção, localização e estadiamento do cancro da próstata. Combina sequências T2 de alta-resolução com pelo menos duas técnicas funcionais, que incluem o estudo dinâmico pós-gadolínio, a difusão e a espectroscopia. O protocolo ideal aconselha a utilização combinada de uma antena de superfície e uma endorectal; contudo, a antena endorectal é apenas obrigatória para a realização de espectroscopia em aparelhos de 1,5 T. Os níveis de sensibilidade e especificidade na detecção e localização do cancro da próstata têm aumentado com a inclusão das técnicas funcionais, quando comparados com as sequências T2 isoladas, o que é particularmente vantajoso em doentes que têm biópsia negativa, apesar de níveis de PSA persistentemente elevados. Para além disso, a informação adicionada pelas técnicas funcionais aparenta correlacionar-se com a agressividade tumoral, podendo tornar-se útil na selecção de doentes radioterapia focal, cirurgias conservadoras, terapias de ablação focal e vigilância activa. Contudo, são necessários mais estudos para comparar as várias técnicas funcionais e compreender as vantagens e desvantagens de cada uma. Este artigo pretender rever os princípios básicos da Ressonância Magnética prostática multiparamétrica, enfatizando o seu papel na detecção, estadiamento e vigilância activa do cancro da próstata. Palavras-chave: Imagem de Difusão por Ressonância Magnética; Neoplasias da Próstata; Ressonância Magnética.

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Evaluating Localized Prostate Cancer and Identifying Candidates for Focal Therapy

Cited by 112 publications

References 106 publications

Molecular genetics of prostate cancer: new prospects for old challenges

Molecular genetics of prostate cancer: new prospects for old challenges

AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis

Prostate Cancer: The Role of Multiparametric Magnetic Resonance Imaging

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