Evaluating inflammation in an obstruction‐based chronic rhinosinusitis model in rabbits

Abstract

sinusitis rabbit model nasal polyps paranasal rhinitis How to Cite this Article Schilling AL Moore J Kulahci Y et al Evaluating inflammation in an obstruction-based chronic rhinosinusitis model in rabbits Int Forum Allergy Rhinol

Reply: A preclinical model to tackle chronic rhinosinusitis

“…An involvement score was included to reflect whether the observation was diffuse or concentrated to a section of the sinus mucosa. Although there was no statistically significant differences in scores between the left and right sides, 3 there was mild to moderate inflammation of the submucosal glands and mild to severe subepithelial edema observed on both sides. Because the study was internally controlled, there were no naive subjects, so the effect of unilateral obstruction on these bilateral histologic observations cannot be fully elucidated at this time.…”

“…(E,F) However, there was no effect seen in 2 subjects. Error bars represent mean ± standard deviation of the median CT # measured on 3 consecutive microcomputed tomography sections (see Methods in our work 3…”

“…However, evidence of bilateral opacification was found in the microCT results, which correlated with damage to the ciliated epithelium. 3 In future work, it would be beneficial to confirm these correlations and also include naive animals for histologic comparison.…”

Evaluation of animal models of Crohn's disease with anal fistula (Review)

“…Rabbits are easy to maintain and rabbit models are cost-effective and have satisfactory repeatability and operability. A variety of preclinical rabbit models have been widely reported (48)(49)(50). In these models, the auxiliary examinations of the human body, such as ultrasound, CT, MRI and endoscopy, are able to be successfully simulated.…”

A preclinical model to tackle chronic rhinosinusitis

“…We were delighted to read the recent article by Schilling and colleagues and we commend the authors for their efforts in quantifying the radiography and histologic findings in this preclinical model. 1 As the authors pointed out in the introduction, chronic rhinosinusitis (CRS) is known to be a multifactorial disease process characterized by impaired mucociliary clearance (MCC) with subsequent compromised microbial elimination. Subsequently, hypoxia due to obstruction of the osteomeatal complex is widely considered one of the major pathogenic mechanisms leading to chronic inflammation, and this is strongly supported by evidence that hypoxia is present at the surface epithelium in diseased sinuses of closed ostia.…”