Evaluating Fallopian Tube Patency: What the Radiologist Needs to Know

Grigovich, Maria; Kacharia, Vidhi S.; Bharwani, Nishat; Hemingway, A. P.; Mijatovic, Velja; Rodgers, Shuchi K.

doi:10.1148/rg.2021210033

Cited by 21 publications

(36 citation statements)

References 61 publications

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“…In general, HyCoSy is a well‐tolerated procedure with a low risk of side effects or complications 39,45 . The main complications include pain, vasovagal reaction, nausea, and vomiting.…”

Section: Discussionmentioning

confidence: 99%

“…Differences between the two techniques were not significant. In addition, HyCoSy was less invasive and reduced unnecessary radiation exposure compared to HSG 39 . More recently, magnetic resonance HSG (MR‐HSG) shows promising potential in the work‐up of female infertility.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, HyCoSy was less invasive and reduced unnecessary radiation exposure compared to HSG. 39 More recently, magnetic resonance HSG (MR-HSG) shows promising potential in the work-up of female infertility. A systematic review and meta-analysis published in 2020 compared the diagnostic performance between HyCoSy and MR-HSG.…”

Section: Discussionmentioning

confidence: 99%

“…In general, HyCoSy is a well-tolerated procedure with a low risk of side effects or complications. 39,45 The main complications include pain, vasovagal reaction, nausea, and vomiting. The vast majority of patients did not complain about pain or other discomforts during the examination involved in this study (91.8-97.6%).…”

Section: Discussionmentioning

confidence: 99%

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Is Hysterosalpingo‐Contrast Sonography (HyCoSy) Using Sulfur Hexafluoride Microbubbles (SonoVue) Sufficient for the Assessment of Fallopian Tube Patency? A Systematic Review and Meta‐Analysis

Zhang

et al. 2022

J of Ultrasound Medicine

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This study aimed to evaluate the diagnostic value of HyCoSy using sulfur hexafluoride microbubbles for fallopian tubal patency assessment in infertile females. Twenty-four studies, including 1358 females with 2661 detected fallopian tubes published from January 2003 to May 2019, were identified. The pooled sensitivity was 93% (95% CI: 90-95%), while the specificity was 90% (95% CI: 87-92%). The area under the receiver-operating characteristic curve was 0.96 (95% CI: 94-98%). The specificity of the four-dimensional HyCoSy subgroup was higher than the 2D/3D subgroup; an increased dose of contrast agent did not affect the specificity, with only a slightly reduced sensitivity.

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“…In general, HyCoSy is a well‐tolerated procedure with a low risk of side effects or complications 39,45 . The main complications include pain, vasovagal reaction, nausea, and vomiting.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Is Hysterosalpingo‐Contrast Sonography (HyCoSy) Using Sulfur Hexafluoride Microbubbles (SonoVue) Sufficient for the Assessment of Fallopian Tube Patency? A Systematic Review and Meta‐Analysis

Zhang

et al. 2022

J of Ultrasound Medicine

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“…While increased iodine levels were universal, there was substantial variability in the magnitude and timing of the peak iodine excess, likely reflecting variable amounts of retained peritoneal OSCM. Moreover, OSCM produces a globular spill into the peritoneum ( 9 , 32 , 33 ) and a variable release of iodine from the globules of different sizes may have a role. Retained peritoneal OSCM was established as a reservoir of iodine/OSCM, suggesting that a delayed pelvic radiograph 45 minutes after an OSCM HSG may be a simple qualitative way of assessing iodine exposure and risk of developing thyroid dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography

Mathews

Peart

Sim

et al. 2022

The Journal of Clinical Endocrinology &Amp; Metabolism

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Context Hysterosalpingography with oil-soluble contrast medium (OSCM) improves pregnancy rates. However, OSCM has high iodine content and long half-life, leading to potential iodine excess. Objective To determine the pattern of iodine excess after OSCM hysterosalpingography and the impact on thyroid function. Design A prospective cohort study. Participants 196 consecutive consenting eligible women without overt hypothyroidism or hyperthyroidism were recruited. All completed the study with compliance >95%. Interventions Participants underwent OSCM hysterosalpingography (Auckland, 2019-2021) with serial monitoring of thyroid stimulating hormone (TSH), free thyroxine (FT4) and urine iodine concentration (UIC) for 24 weeks. Main Outcome measure Development of subclinical hypothyroidism (SCH), defined as a non-pregnant TSH >4 mIU/L with normal FT4 (11–22 pmol/L), in those with normal baseline thyroid function. Results Iodine excess (UIC ≥300 μg/L) was almost universal (98%) with UIC peaking usually by four weeks. There was marked iodine excess, with 90% and 17% of participants having UIC ≥1000 μg/L and >10,000 μg/L, respectively. Iodine excess was prolonged with 67% having a UIC ≥1000 μg/L for at least three months. SCH developed in 38%; the majority (96%) were mild (TSH 4–10 mIU/L) and most developed SCH by week 4 (75%). Three participants met the current treatment guidelines (TSH >10 mIU/L). Thyroxine treatment of mild SCH tended to improve pregnancy success [p = 0.063]. Hyperthyroidism (TSH <0.3 mIU/L) occurred in 9 participants (5%). Conclusions OSCM hysterosalpingography resulted in marked and prolonged iodine excess. SCH occurred frequently with late-onset hyperthyroidism occasionally. Regular thyroid function tests are required for 6 months following this procedure.

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Risk Factors of Contrast Agent Intravasation With Sulfur Hexafluoride Microbubble During Hysterosalpingo‐Contrast Sonography

Jin

Zhao

et al. 2023

J of Ultrasound Medicine

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Objectives To analyze the risk factors of sulfur hexafluoride microbubble contrast agent intravasation during hysterosalpingo‐contrast sonography (HyCoSy), and to explore a simple prediction model by the obvious clinical history. Methods This was a retrospective study included 299 infertility women who had undergone HyCoSy examination from July 1, 2018 to June 31, 2019. The factors were recorded, including age, endometrial thickness, balloon length, infertility type, history of intrauterine surgery, history of pelvic surgery, and tubal patency. The method of multivariate logistic regression analysis was adopted to analyze the risk factors affecting the contrast agent intravasation, and the receiver operating characteristic curves were plotted to test their efficacy. Results Secondary infertility, a history of intrauterine surgery, thin endometrial thickness, and tubal obstruction were all risk factors of the occurrence of intravasation (P < .05). And the area under the receiver operating characteristic curves of the multifactor‐combined prediction model of the intravasation was significantly larger than that of single‐factor. Conclusions Sonographers and gynecologists should be familiar with the risk factors of intravasation and select the appropriate timing of HyCoSy toward reducing the occurrence of intravasation and other complications after thoroughly explaining and communicating with the patients.

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Evaluating Fallopian Tube Patency: What the Radiologist Needs to Know

Cited by 21 publications

References 61 publications

Is Hysterosalpingo‐Contrast Sonography (HyCoSy) Using Sulfur Hexafluoride Microbubbles (SonoVue) Sufficient for the Assessment of Fallopian Tube Patency? A Systematic Review and Meta‐Analysis

Is Hysterosalpingo‐Contrast Sonography (HyCoSy) Using Sulfur Hexafluoride Microbubbles (SonoVue) Sufficient for the Assessment of Fallopian Tube Patency? A Systematic Review and Meta‐Analysis

The SELFI Study: Iodine Excess and Thyroid Dysfunction in Women Undergoing Oil-Soluble Contrast Hysterosalpingography

Risk Factors of Contrast Agent Intravasation With Sulfur Hexafluoride Microbubble During Hysterosalpingo‐Contrast Sonography

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