Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations

Ramstedt, Madeleine; Ribeiro, Isabel; Bujdáková, Helena; Mergulhão, Filipe; Jordão, Luísa; Thomsen, Peter; Alm, Martin; Burmølle, Mette; Vladkova, T.; Can, Füsun; Reches, Meital; Riool, Martijn; Barros, Alexandre A.; Reis, Rui L.; Meaurio, Emilio; Kikhney, Judith; Moter, Annette; Zaat, Sebastian A. J.; Sjollema, Jelmer

doi:10.1002/mabi.201800384

Cited by 71 publications

(88 citation statements)

References 212 publications

(179 reference statements)

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“…Therefore, designing the surface with excellent antibiofouling and self‐healing functions is significant for engineering and biomedicine applications. In the past years, there are some excellent review reports on the antibiofouling included the antibiofouling materials, antibiofouling mechanism, and the antibiofouling design principles . Herein, we mainly focus on the mechanisms of the surface with antibiofouling and self‐healing abilities at interface, particularly the mechanisms up to molecular level and it is anticipated that the description on several typical examples can provide the general design methods for antibiofouling and self‐healing surface.…”

Section: Self‐healing Functional Surfacementioning

confidence: 99%

Flourishing Self‐Healing Surface Materials: Recent Progresses and Challenges

Tie

Panhwar

Zhao

2020

Adv Materials Inter

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In the past few decades, the self‐healing surface materials with durable mechanical, functional, and structural properties have attracted enormous research interests, which exhibit great potential in energy conversion devices, sensors, electronic skins, superhydrophobic fabrics, medical/biological hydrogel, and a protective coating. Despite the remarkable progresses achieved in the self‐healing surface, the systematic and overall reviews that focus on self‐healing surface materials are still lacking and in urgent need. Herein, the recent advances in the development of self‐healing surface materials are summarized. The surface damage forms that composed of cracks, scratches, punctures, and surface wear, are systematically reviewed. The self‐healing mechanism and methods at interface are then introduced to briefly explain the basic design principle. The recent developments of functional surfaces including superhydrophobic, oleophobic, antifogging, anti‐icing, antibiofouling, and anticorrosion surfaces with self‐healing functions are further discussed. Finally, the contemporary challenges, and the future perspectives that motivate are proposed to create more innovative self‐healing materials for diverse fields.

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Section: Self‐healing Functional Surfacementioning

confidence: 99%

Flourishing Self‐Healing Surface Materials: Recent Progresses and Challenges

Tie

Panhwar

Zhao

2020

Adv Materials Inter

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“…A flow rate of 2 mL s −1 was used, which yields a shear rate of 15 s −1 and a shear stress of 0.01 Pa [68]. This shear rate is typical for urinary catheters [81] and stents [82], where E. coli is one of the most relevant microbial colonizers [45]. The equipment was also coupled to a water bath to keep a constant temperature of 37 • C. For each sample, the medium with E. coli was allowed to flow for 30 min, after which the coatings were removed and stained with 4 -6-diamidino-2-phenylindole for later visualization under fluorescence microscopy (Nikon Eclipse LV100 series, magnification 100×, Nikon Corporation, Tokyo, Japan) and total cell counts.…”

Section: E Coli Adhesion Assaysmentioning

confidence: 99%

“…Therefore, a deeper investigation of the interactions between bacterial cells and CNT-polymer composites at the interface level could provide insights into the use of CNT-based coatings in medical implants. Testing of these new composites should be performed in hydrodynamic conditions that are relevant for their final application [44] as flow affects the transport of bacteria to the surface and also the forces that adhered cells have to withstand [45]. Additionally, it has been shown that initial adhesion can provide very useful information regarding the antifouling performance of a surface or a coating [46,47].…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanotube/Poly(dimethylsiloxane) Composite Materials to Reduce Bacterial Adhesion

et al. 2020

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Different studies have shown that the incorporation of carbon nanotubes (CNTs) into poly(dimethylsiloxane) (PDMS) enables the production of composite materials with enhanced properties, which can find important applications in the biomedical field. In the present work, CNT/PDMS composite materials have been prepared to evaluate the effects of pristine and chemically functionalized CNT incorporation into PDMS on the composite’s thermal, electrical, and surface properties on bacterial adhesion in dynamic conditions. Initial bacterial adhesion was studied using a parallel-plate flow chamber assay performed in conditions prevailing in urinary tract devices (catheters and stents) using Escherichia coli as a model organism and PDMS as a control due to its relevance in these applications. The results indicated that the introduction of the CNTs in the PDMS matrix yielded, in general, less bacterial adhesion than the PDMS alone and that the reduction could be dependent on the surface chemistry of CNTs, with less adhesion obtained on the composites with pristine rather than functionalized CNTs. It was also shown CNT pre-treatment and incorporation by different methods affected the electrical properties of the composites when compared to PDMS. Composites enabling a 60% reduction in cell adhesion were obtained by CNT treatment by ball-milling, whereas an increase in electrical conductivity of seven orders of magnitude was obtained after solvent-mediated incorporation. The results suggest even at low CNT loading values (1%), these treatments may be beneficial for the production of CNT composites with application in biomedical devices for the urinary tract and for other applications where electrical conductance is required.

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“…The fixed cells were stained using the Live/Dead Backlight viability kit with following the manufacturer's protocol. Samples were examined with Leica DMI8 laser scanning confocal microscope (15,16).…”

Section: Assessment Of Biofilm Formationmentioning

confidence: 99%

Biofilm Formation of Acinetobacter baumannii Under in vitro and in vivo Colistin Exposure

Özer¹,

Vatansever²,

Doğan³

et al. 2019

Infect Dis Clin Microbiol

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A cinetobacter baumannii is one of the most pathogenic nosocomial infection agents because of its extreme resistance to almost all known antibiotics and host immune responses (1). The emergence of colistin-resistance in A. baumannii has been reported throughout the world (2, 3). Biofilm formation ability enhances virulence of A. baumannii by increasing survival of cells in unfavourable environmental conditions, such as underexposure of disinfectants, antibiotics or attack of immune cells (4, 5). Antibiotic-resistant phenotypes This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.

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Evaluating Efficacy of Antimicrobial and Antifouling Materials for Urinary Tract Medical Devices: Challenges and Recommendations

Cited by 71 publications

References 212 publications

Flourishing Self‐Healing Surface Materials: Recent Progresses and Challenges

Flourishing Self‐Healing Surface Materials: Recent Progresses and Challenges

Carbon Nanotube/Poly(dimethylsiloxane) Composite Materials to Reduce Bacterial Adhesion

Biofilm Formation of Acinetobacter baumannii Under in vitro and in vivo Colistin Exposure

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