Evaluating association of vaccine response to low serum zinc and vitamin D levels in children of a birth cohort study in Dhaka

Das, Rina; Chisti, Mohammod Jobayer; Haque, Md. Ahshanul; Alam, Md. Ashraful; Das, Subhasish; Mahfuz, Mustafa; Mondal, Dinesh; Ahmed, Tahmeed

doi:10.1016/j.vaccine.2020.10.048

Cited by 12 publications

(15 citation statements)

References 47 publications

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“…There is a correlation between the serum zinc level and the titer of antibodies produced by the tetanus vaccine in children (OR 1.84; 95% CI 1.07–3.17, p = 0.028). This association persisted regardless of age, gender, birth weight, diarrhea, breastfeeding history, serum ferritin and retinol concentrations, and malnutrition [51].…”

Section: Discussionmentioning

confidence: 99%

“…There is a correlation between the serum zinc level and the titer of antibodies produced by the tetanus vaccine in children (OR 1.84; 95% CI 1.07-3.17, p = 0.028). This association persisted regardless of age, gender, birth weight, diarrhea, breastfeeding history, serum ferritin and retinol concentrations, and malnutrition [51]. Supplementation of zinc (5 mg/day) and of a probiotic (Lactobacillus rhamnosus GG, 10 10 CFU/day) influenced the immune response to oral rotavirus vaccine in infants aged 5 weeks.…”

Section: Zinc and The Effects Of Vaccinationmentioning

confidence: 92%

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Computational systematics of nutritional support of vaccination against viral and bacterial pathogens as prolegomena to vaccinations against COVID-19

Torshin

Gromova

Chuchalin

2021

Preprint

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A total of 6,628 PUBMED-registered publications on the relationships between the effects of vaccination and the provision of micronutrients have been studied by methods of topological analysis of text data. In case of insufficient intake of certain micronutrients, the functioning of the acquired immunity is disrupted resulting in an imbalance of populations of T-cells CD4+/CD8+ and of B-lymphocytes. Nutritional supplements of folate, vitamins A, D and B12, which are recognized regulators of cell division, support a wide range of lymphocyte populations. Trace elements zinc, iron, selenium, manganese and omega-3 polyunsaturated fatty acids are also important for supporting the mechanisms of acquired immunity. The data presented show that a course intake of these micronutrients by patients planning vaccination can significantly improve its effectiveness. In particular, these micronutrients can increase the titers of antibodies to pathogens, and to reduce the percentage of patients who still contract infection after vaccination. Supplements of these micronutrients can also contribute to the safety of vaccination: to prevent malaise and, in the unfortunate case of contracting infection despite the vaccine, to reduce the severity of the course and the mortality from the corresponding infection.

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Section: Discussionmentioning

confidence: 99%

Section: Zinc and The Effects Of Vaccinationmentioning

confidence: 92%

Computational systematics of nutritional support of vaccination against viral and bacterial pathogens as prolegomena to vaccinations against COVID-19

Torshin

Gromova

Chuchalin

2021

Preprint

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“…27 Socioeconomic data were collected every 6 months, starting from 6 months of age of the participant. The water, sanitation, hygiene, asset, maternal education, and income index (WAMI), which ranges from 0 to 1 point, is an index of socioeconomic status of the households 28 and was calculated subsequently. Greater socioeconomic status was indicated by a higher WAMI.…”

Section: Methodsmentioning

confidence: 99%

Risk Factors for Enterotoxigenic Bacteroides fragilis Infection and Association with Environmental Enteric Dysfunction and Linear Growth in Children: Results from the MAL-ED Study

Palit

Das

Haque

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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Despite reports of enterotoxigenic Bacteroides fragilis (ETBF) isolation from asymptomatic children, no reports exist regarding the possible association of ETBF with long-term complications such as development of environmental enteric dysfunction (EED) and subsequent linear growth faltering in childhood. We aimed to establish a potential association between the burden of asymptomatic ETBF infection and EED and linear growth at 24 months of age using the data collected from 1,715 children enrolled in the multi-country birth cohort study, known as the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health study. Using Poisson regression models, we evaluated the site-specific incidence rate and, subsequently, identified the risk factors and assessed the association between the burden of ETBF infection and EED score and linear growth at 24 months of age. The overall incidence rate of ETBF infections per 100 child-months across all study sites was 10.6%, with the highest and lowest incidence of ETBF infections being reported in Tanzania (19.6%) and Peru (3.6%), respectively. Female gender, longer duration of breastfeeding, and improved water access, sanitation, and hygiene practices, such as improved drinking water source, improved sanitation, and improved floor material in households, along with enhanced maternal education and less crowding in the households were found to be protective against incidences of ETBF infection. The burden of ETBF infections was found to have significant associations with EED and linear growth faltering at 24 months of age across all the study sites. Our findings warrant regular clinical monitoring to reduce the burden of ETBF infections and diminish the burden of enteropathy and linear growth faltering in childhood.

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“…The plates were read at 492 nm, and a four-parameter fit of the transformed optical density values computed the titers. 28 Statistical analysis. We first tabulated variables related to the household, maternal health, and child nutritional status using descriptive statistics (mean, standard deviation, and percentages, as appropriate).…”

Section: Methodsmentioning

confidence: 99%

Associations of Enteric Protein Loss, Vaccine Response, Micronutrient Deficiency, and Maternal Depressive Symptoms with Deviance in Childhood Linear Growth: Results from a Multicountry Birth Cohort Study

Das

Chowdhury

Gazi

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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We identified the determinants of positive (children who had a birth weight < 2.5 kg and/or maternal height < 145 cm but were nonstunted at 24 months of age) and negative (children who had a birth weight ≥ 2.5 kg and maternal height ≥ 145 cm but were stunted at 24 months of age) deviance in childhood linear growth. We found that socioeconomic status (β = 1.54, P < 0.01), serum retinol (β = 0.05, P < 0.01), hemoglobin (β = 0.36, P < 0.01), length-for-age Z-score (LAZ) at birth (β = 0.47, P < 0.01), and tetanus vaccine titer (β = 0.182, P < 0.05) were positively and maternal depressive symptom (β = –0.05, P < 0.01), serum ferritin (β = –0.03, P < 0.01), male sex (β = –1.08, P < 0.01), and α1-antitrypsin (β = –0.81, P < 0.01) were negatively associated with positive deviance. Further, diarrhea episodes (β = 0.02, P < 0.01), male sex (β = 0.72, P < 0.01), and α1-antitrypsin (β = 0.67, P < 0.01) were positively and hemoglobin (β= –0.28, P < 0.01), soluble transferrin receptor level (β = –0.15, P < 0.01), and LAZ score at birth (β = –0.90, P < 0.01) were negatively associated with negative deviance. To summarize, enteric protein loss, micronutrient deficiency, vaccine responses and maternal depressive symptoms were associated with linear growth deviance in early childhood. In such a background, public health approaches aimed at reducing the risk of intestinal inflammation and altered gut permeability could prove fruitful in ensuring desired linear growth in children. In addition, maternal mental health issue should also be considered, especially for promoting better nutritional status in children in the context of linear growth deviance.

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Evaluating association of vaccine response to low serum zinc and vitamin D levels in children of a birth cohort study in Dhaka

Cited by 12 publications

References 47 publications

Computational systematics of nutritional support of vaccination against viral and bacterial pathogens as prolegomena to vaccinations against COVID-19

Computational systematics of nutritional support of vaccination against viral and bacterial pathogens as prolegomena to vaccinations against COVID-19

Risk Factors for Enterotoxigenic Bacteroides fragilis Infection and Association with Environmental Enteric Dysfunction and Linear Growth in Children: Results from the MAL-ED Study

Associations of Enteric Protein Loss, Vaccine Response, Micronutrient Deficiency, and Maternal Depressive Symptoms with Deviance in Childhood Linear Growth: Results from a Multicountry Birth Cohort Study

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