Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer

Gill, Balraj Singh; Kumar, Sanjeev; Navgeet,

doi:10.1007/s11033-016-4074-z

Cited by 27 publications

(9 citation statements)

References 28 publications

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“…During our initial screening, GA-A stood out among the 12 purified GA monomers because of its optimal in vitro activity in the MDCK cyst model. GA-A has been found to suppress the proliferation, metastasis and adhesion of breast cancer cells, prostate cancer cells, pancreatic cancer cells, etc., in previous studies [ 35 – 37 ]. The mechanisms by which GA-A inhibits cell proliferation and viability and accelerates cell apoptosis mainly involve a decrease in Cdk4, which targets the STAT3 and Wnt proteins [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 81%

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

Meng

Wang

et al. 2020

Acta Pharmacol Sin

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Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common life-threatening monogenetic diseases characterized by progressive enlargement of fluid-filled renal cysts. Our previous study has shown that Ganoderma triterpenes (GT) retards PKD renal cyst development. In the present study we identified the effective ingredient of GT in suppression of kidney cyst development. Using an in vitro MDCK cystogenesis model, we identified ganoderic acid A (GA-A) as the most promising candidate among the 12 ganoderic acid (GA) monomers. We further showed that GA-A (6.25−100 μM) significantly inhibited cyst growth in MDCK cyst model and embryonic kidney cyst model in vitro, and the inhibitory effect was reversible. In kidney-specific Pkd1 knockout (kPKD) mice displaying severe cystic kidney disease, administration of GA-A (50 mg· kg −1 ·d −1 , sc) significantly attenuated renal cyst development. In both MDCK cells and kidney of kPKD mice, we revealed that GA-A dose-dependently downregulated the Ras/MAPK signaling pathway. The expression of proliferating cell nuclear antigen (PCNA) was also suppressed, suggesting a possible effect of GA-A on cell proliferation. These experimental data suggest that GA-A may be the main ingredient of GT as a potential therapeutic reagent for treating ADPKD.

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Section: Discussionmentioning

confidence: 81%

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

Meng

Wang

et al. 2020

Acta Pharmacol Sin

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“…Mn-SOD is a kind of superoxide dismutase located in the mitochondrial matrix which takes manganese ion as the active center, can protect the cells from oxidative stress by converting superoxide anion into less toxic hydrogen peroxide [ 23 ]. We further studied the effect of bibenzyl derivatives in D. officinale on Mn-SOD and SIRT3 activity in vitro.…”

Section: Resultsmentioning

confidence: 99%

The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

Chen

Shao

Liu

et al. 2022

Nat. Prod. Bioprospect.

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Dendrobium officinale is a valuable medicinal herb that is widely used in traditional Chinese medicine. The chemical constituents of D. officinale have attracted much attention and a large number of compounds have been reported including many bibenzyl derivatives. 13 bibenzyl derivatives from D. officinale were sent for molecular docking, surface plasmon resonance (SPR) assay and after detection of Mn-SOD and SIRT3 activities in or not in HaCaT cells, it was concluded that bibenzyl derivatives did not directly activate Mn-SOD but promoted SIRT3 proteins. In addition, HaCaT cells were irradiated with UV-B to induce an oxidative stress model in vitro to further verify the effect of bibenzyl derivatives. The results show that bibenzyl derivatives could directly bind to SIRT3, enhance the deacetylation and then activate Mn-SOD, so as to protect UV-B induced skin photoaging. Graphical Abstract

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“…Similarly, increased STAT-3 activation and its DNA binding occur in the prostate of mice fed a high-fat diet [57]. In human PC cells, the inhibition of STAT-3 results in the inhibition of cell proliferation and a significant decrease in cell viability [58].…”

Section: Oxidative Stressmentioning

confidence: 99%

Dietary Carcinogens and DNA Adducts in Prostate Cancer

Bellamri

Turesky

2019

Advances in Experimental Medicine and Biology

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Prostate cancer (PC) is the most commonly diagnosed non-cutaneous cancer and the second leading cause of cancer-related to death in men. The major risk factors for PC are age, family history, and African American ethnicity. Epidemiological studies have reported large geographical variations in PC incidence and mortality, and thus lifestyle and dietary factors influence PC risk. High fat diet, dairy products, alcohol and red meats, are considered as risk factors for PC. This book chapter provides a comprehensive, literature-based review on dietary factors and their molecular mechanisms of prostate carcinogenesis. A large portion of our knowledge is based on epidemiological studies where dietary factors such as cancer promoting agents, including high-fat, dairy products, alcohol, and cancer-initiating genotoxicants formed in cooked meats have been evaluated for PC risk. However, the precise mechanisms in the etiology of PC development remain uncertain. Additional animal and human cell-based studies are required to further our understandings of risk factors involved in PC etiology. Specific biomarkers of chemical exposures and DNA damage in the prostate can provide evidence of cancer-causing agents in the prostate. Collectively, these studies can improve public health research, nutritional education and chemoprevention strategies

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Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer

Cited by 27 publications

References 28 publications

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

Ganoderic acid A is the effective ingredient of Ganoderma triterpenes in retarding renal cyst development in polycystic kidney disease

The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3

Dietary Carcinogens and DNA Adducts in Prostate Cancer

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