Evaluación del daño en el ADN y vigilancia biológica de la exposición laboral a solventes orgánicos, 2006

Torres, Carlos Humberto; Varona, Marcela; Lancheros, Angélica; Patiño, Rosa Isabel; Groot, Helena

doi:10.7705/biomedica.v28i1.115

Cited by 12 publications

(8 citation statements)

References 40 publications

(36 reference statements)

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“…This study evaluated the genotoxic effects of exposure to organic solvents in a sample of workers routinely exposed to organic solvents due to work activities associated with car painting, and workers non-exposed to these agents. The average age observed in both groups were like those found in the available reports of the working population in Colombia, and in other studies with similar working populations 27 . On the other hand, it is important to note that the time of exposure for the exposed group was approximately 21 years, and in addition, some of them performed tasks related to painting activities in their free time.…”

Section: Discussionsupporting

confidence: 89%

“…With respect to respiratory protection, the picture was no different, because only 32% used a filter respirator and, even more alarming, only 12% used a filter suitable for organic vapors. The above conditions are concerning, especially since they have been consistently described in other populations also exposed to organic solvents 27 .…”

Section: Discussionmentioning

confidence: 91%

“…Este estudio evaluó los efectos genotóxicos por exposición a solventes orgánicos en una muestra de trabajadores rutinariamente expuestos a solventes orgánicos debido a actividades laborales asociadas con la pintura de carros, y trabajadores no expuestos a esos agentes. El promedio de edad observado en ambos grupos fue como los que se encuentran en los informes disponibles de la población laboral activa en Colombia y en otros estudios de poblaciones con trabajos similares 27 . Por el otro lado, es importante mostrar que el tiempo de exposición para el grupo expuesto fue de aproximadamente 21 años, y adicionalmente, algunos de ellos realizan actividades relacionadas con actividades de pintura en sus tiempos libres.…”

Section: Discussionunclassified

“…Con respecto a la protección respiratoria, el escenario no es diferente, debido a que sólo el 32% usan un respirador con filtro y, aún más alarmante, sólo el 12% usan un filtro apropiado para vapores orgánicos. Las condiciones anteriores son preocupantes, especialmente porque estas ya han sido consistentemente descritas en otras poblaciones también expuestas a los solventes orgánicos 27 .…”

Section: Discussionunclassified

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Biomarkers of susceptibility and effect in car painters exposed to organic solvents

et al. 2020

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Introduction: Car painters are routinely exposed to organic solvents classified as carcinogenic and mutagenic substances. Objective: To characterize the population susceptibility and evaluate the genotoxic effects of exposure to organic solvents. Methods: A cross-sectional study comparing a group of car painters exposed to organic solvents with a non-exposed group. CYP2E1 polymorphisms and the presence of micronuclei in lymphocytes were determined. Results: One hundred twenty-two workers participated in the study: 62 who worked in car paint shops and were exposed to solvents, and 60 who were not exposed. There were statistically significant differences between the two groups regarding micronucleated cells and nucleoplasmic bridges frequencies (p=0.042 and p=0.046, respectively; exact likelihood ratio). Significant differences were found at the interaction between the CYP2E1 genotype c1c1 and occupational exposure to solvents, with higher frequencies of micronuclei (p= 0.013) and micronucleated cells (p= 0.015). However, when the frequencies of micronuclei, micronucleated cells and nucleoplasmic bridges in the exposure group were compared between the c1c1 and c2c2/c1c2 allele groups of the CYP2E1 polymorphism, statistically significant differences were found. Conclusions: This study confirms that when workers with CYP2E1 polymorphisms, specifically the c1c1 genotype, are exposed to organic solvents, they are more likely to have somatic cell mutations, a condition associated with increased susceptibility to diseases such as cancer

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 91%

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Biomarkers of susceptibility and effect in car painters exposed to organic solvents

et al. 2020

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“…Aunque no se observaron diferencias estadís-ticamente significativas en los síntomas del grupo expuesto, comparado con el de los no expuestos, sí se encontró una mayor frecuencia en la (29). También hubo mayor frecuencia de los síntomas incluidos en el cuestionario Q16, en estos mismos trabajadores.…”

Section: Resultsunclassified

Evaluación de la exposición a solventes orgánicos en pintores de carros de la ciudad de Bogotá

et al. 2015

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Contribución de los autores:Ruth Marien Palma: elaboración del protocolo y trabajo de campo Todos los autores participaron en el análisis estadístico de los datos y en la escritura del manuscrito. Introducción. Los pintores de vehículos automotores están expuestos a solventes puros o mezclas, los cuales se han asociado con efectos neurológicos, mutagénicos y cancerígenos. Objetivo. Caracterizar las condiciones de salud y de trabajo de individuos expuestos a solventes orgánicos empleados en talleres de lámina y pintura de carros de Bogotá. Materiales y métodos. Se hizo un estudio transversal descriptivo en el que se caracterizaron las condiciones de salud y de trabajo de individuos expuestos a solventes orgánicos en talleres de lámina y pintura en Bogotá. Se comparó un grupo de trabajadores expuestos a solventes orgánicos con un grupo no expuesto. Se determinaron las concentraciones de benceno, tolueno y xileno en el aire, se hizo una encuesta individual y se midieron los ácidos fenil-mercaptúrico, hipúrico, orto y parametilhipúrico en orina. Los resultados de las mediciones y de la encuesta se correlacionaron para establecer el panorama de exposición. Evaluación de la exposición a solventes orgánicos en pintores de carros de la ciudad de BogotáResultados. Hubo diferencias estadísticamente significativas entre la población expuesta y la no expuesta a solventes (p<0,001) en cuanto a los tres metabolitos de benceno, tolueno y xileno. Se encontraron correlaciones positivas entre el tolueno en el aire y el ácido hipúrico en la orina de los individuos expuestos (ro=0,82), y entre el xileno en el aire y el ácido o-metilhipúrico (ro=0,76). Los valores del ácido hipúrico estuvieron por encima de los límites permisibles en 11 trabajadores y, los de ácido p-metilhipúrico, en ocho de ellos. No se registraron valores de ácido fenil-mercaptúrico por fuera del límite permitido. Conclusión. Los pintores de carros están expuestos a niveles altos de solventes orgánicos en sus sitios de trabajo, y no tienen condiciones adecuadas de higiene y seguridad industrial para realizar sus labores.Palabras clave: solventes, benceno, tolueno, exposición ocupacional.doi: http://dx.doi.org/10.7705/biomedica.v35i0.2268 Evaluation of exposure of auto painters to organic solvents in the city of BogotaIntroduction: Painters of automobiles are exposed to pure and mixed solvents that have been associated with neurological effects and carcinogenic mutations. Objective: To characterize the health and work conditions of individuals who are occupationally exposed to organic solvents used in sheet metal and auto body shops in Bogota. Materials and methods: Descriptive, cross-sectional study that characterizes the health and work conditions of individuals exposed to organic solvents in sheet metal and auto body shops in Bogota. A group exposed to the solvents was compared to an unexposed group. Air concentrations of benzene, toluene and xylene (BTX) were determined, individual questionnaires were administered and phenylmercapturic, hippuric and ortho-and ...

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The effects of genetic polymorphisms on benzene‐exposed workers: A systematic review

Ramírez‐Lopera

Uribe‐Castro

Bautista-Amorocho

et al. 2021

Health Science Reports

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Background and Aims Benzene is a group I carcinogen, which has been associated with leukemia and myelodysplastic syndrome. Moreover, it has been proposed that polymorphisms in benzene metabolizing genes influence the outcomes of benzene exposure in the human body. This systematic review aims to elucidate the existent relationship between genetic polymorphisms and the risk of developing adverse health effects in benzene‐exposed workers. Methods Three databases were systematically searched until April 2020. The preferred reporting items for systematic reviews and meta‐analyses method was used to select articles published between 2005 and 2020. Quality assessment and risk of bias were evaluated by the Newcastle‐Ottawa scale. Results After full‐text evaluation, 36 articles remained out of 645 initially screened. The most studied health effects within the reviewed papers were chronic benzene poisoning, hematotoxicity, altered urinary biomarkers of exposure, micronucleus/chromosomal aberrations, and gene methylation. Furthermore, some polymorphisms on NQO1 , GSTT1 , GSTM1 , MPO , and CYP2E1 , among other genes, showed a statistically significant relationship with an increased risk of developing at least one of these effects on benzene‐exposed workers. However, there was no consensus among the reviewed papers on which specific polymorphisms were the ones associated with the adverse health‐related outcomes, except for the NQO1 rs1800566 and the GSTT1 null genotypes. Additionally, the smoking habit was identified as a confounder, demonstrating worse health outcomes in exposed workers that smoked. Conclusion Though there is a positive relationship between genetic polymorphisms and detrimental health outcomes for benzene‐exposed workers, broader benzene‐exposed cohorts that take into account the genetic diversity of the population are needed in order to determine which specific polymorphisms incur in health risks.

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Evaluación del daño en el ADN y vigilancia biológica de la exposición laboral a solventes orgánicos, 2006

Cited by 12 publications

References 40 publications

Biomarkers of susceptibility and effect in car painters exposed to organic solvents

Biomarkers of susceptibility and effect in car painters exposed to organic solvents

Evaluación de la exposición a solventes orgánicos en pintores de carros de la ciudad de Bogotá

The effects of genetic polymorphisms on benzene‐exposed workers: A systematic review

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