The guinea pig (Cavia porcellus) is a species of social and cultural importance in the southwestern region of Colombia. However, information on zootechnical variables is under development. The objective of this work was to identify the behavior of lines, productive and reproductive variables of guinea pigs in Nariño and Putumayo. A survey was applied in 404 productive systems of the municipalities of Pasto-Nariño and Colón, San Francisco, Santiago and Sibundoy-Putumayo. The data were processed in the program IBM-SPSS-Statistics® V. 20.0-2011. The distribution of lines corresponded to crosses: Criolla-Peru-Andina 61.4%, Criolla-14.8%, unidentified line 13.4%, Peru 9.65% and Andina 0.74%. The age at first mating (months) was lower for the Peruvian (5.1) and Andean (4.5) lines than in Creole animals (5.3). The number of births/ females/years in the Peruvian and Andean lines was 3.7 in Creole females was 3.4. The 97.3% of the producers have established groups of mount where the relation male: females, by lines was of 1:6, 1:8 and 1:4 for Criolla, Peru and Andina respectively. The average weights (g) at birth, weaning and benefit were: 222, 413 and 1330 (Criolla), 197, 390 and 1259 (Peru) and 125, 450 and 1300 (Andina) respectively. The age at weaning (days) was 24.5 (Criollos), 19.3 (Peru) and 18.3 days (Andina). It was evidenced predominance in the use of Creole lines and/or crosses. The Peruvian and Andean lines reported greater reproductive efficiency, the Creole race presented a greater productive efficiency. Due to the potential of the system, it is pertinent to carry out a broader characterization.