Euterpe oleracea Mart. (açaí) seed extract associated with exercise training reduces hepatic steatosis in type 2 diabetic male rats

de, Graziele Freitas; Costa, Cristiane Aguiar da; Cordeiro, Viviane da Silva Cristino; Santos, Izabelle Barcellos; Carvalho, Lenize Costa Reis Marins de; Soares, Ricardo de Andrade; Ribeiro, Jéssica Honorato; Souza, Maria das Graças Coelho de; Sousa, Pergentino José da Cunha; Ognibene, Dayane Teixeira; Resende, Ângela Castro; Moura, Roberto Soares de

doi:10.1016/j.jnutbio.2017.09.021

Cited by 22 publications

(19 citation statements)

References 47 publications

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“…We found in Sedentary D group a reduced skeletal muscle pAMPK expression, which is in agreement with previous findings in the same model [ 46 ]. ASE and exercise training alone did not significantly increase pAMPK expression in ASE Sedentary D group, but ASE extract increased this protein expression in liver of type 2 diabetic rats [ 47 ]. The metformin, an antidiabetic drug, increased the AMPK activation in the liver after one week of treatment, but not in skeletal muscle, suggesting a time-dependent effect of metformin on the regulation of skeletal muscle AMPK [ 37 ], which may also occur in the ASE effect.…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction

Costa

Santos

et al. 2018

PLoS ONE

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A growing body of evidence suggests a protective role of polyphenols and exercise training on the disorders of type 2 diabetes mellitus (T2DM). We aimed to assess the effect of the açaí seed extract (ASE) associated with exercise training on diabetic complications induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type 2 diabetes was induced by feeding rats with HF diet (55% fat) for 5 weeks and a single dose of STZ (35 mg/kg i.p.). Control (C) and Diabetic (D) animals were subdivided into four groups each: Sedentary, Training, ASE Sedentary, and ASE Training. ASE (200 mg/kg/day) was administered by gavage and the exercise training was performed on a treadmill (30min/day; 5 days/week) for 4 weeks after the diabetes induction. In type 2 diabetic rats, the treatment with ASE reduced blood glucose, insulin resistance, leptin and IL-6 levels, lipid profile, and vascular dysfunction. ASE increased the expression of insulin signaling proteins in skeletal muscle and adipose tissue and plasma GLP-1 levels. ASE associated with exercise training potentiated the reduction of glycemia by decreasing TNF-α levels, increasing pAKT and adiponectin expressions in adipose tissue, and IR and pAMPK expressions in skeletal muscle of type 2 diabetic rats. In conclusion, ASE treatment has an antidiabetic effect in type 2 diabetic rats by activating the insulin-signaling pathway in muscle and adipose tissue, increasing GLP-1 levels, and an anti-inflammatory action. Exercise training potentiates the glucose-lowering effect of ASE by activating adiponectin-AMPK pathway and increasing IR expression.

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Section: Discussionmentioning

confidence: 99%

Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction

Costa

Santos

et al. 2018

PLoS ONE

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“…For Western blotting, the liver tissue samples were prepared as previously described. [21,25] The total protein content was performed by the BCA protein assay kit (Pierce, Rockford, IL, USA). The Western blotting was realized as previously described.…”

Section: Hepatic Steatosis and Tg Contentmentioning

confidence: 99%

Therapeutic effects of açaí seed extract on hepatic steatosis in high-fat diet-induced obesity in male mice: a comparative effect with rosuvastatin

Tavares

Santos

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Obesity is considered a risk factor for the development of non-alcoholic fatty liver disease (NAFLD). The hydroalcoholic extract obtained from the ac ßai seed (ASE), rich in proanthocyanidins, has been shown a potential body weight regulator with antioxidant properties. This study aimed to investigate the therapeutic effect of ASE in obesity-associated NAFLD and compare it with Rosuvastatin. Methods Male C57BL/6 mice received a high-fat diet or standard diet for 12 weeks. The treatments with ASE (300 mg/kg per day) or rosuvastatin (20 mg/ kg per day) began in the eighth week until the 12th week. Key findings Our data show that the treatments with ASE and rosuvastatin reduced body weight and hyperglycaemia, improved lipid profile and attenuated hepatic steatosis in HFD mice. ASE and Rosuvastatin reduced HMGCoA-Reductase and SREBP-1C and increased ABGC8 and pAMPK expressions in the liver. Additionally, ASE, but not Rosuvastatin, reduced NPC1L1 and increased ABCG5 and PPAR-a expressions. ASE and rosuvastatin increased SIRT-1 expression and antioxidant defence, although only ASE was able to decrease the oxidative damage in hepatic tissue. Conclusions The therapeutic effect of ASE was similar to that of rosuvastatin in reducing dyslipidemia and hepatic steatosis but was better in reducing oxidative damage and hyperglycaemia.

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“…Ngo Sock et al (2014) showed that continuous treadmill exercise has no effect on ileum ABCG5 expression in rats [49]. de Bem et al (2018) showed that exercise training has no significant changes in liver ABCG5 in rat [62].…”

Section: Abcg4mentioning

confidence: 99%

Effects of exercise on reverse cholesterol transport: A systemized narrative review of animal studies

et al. 2019

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Aims: Reverse Cholesterol Transport (RCTr) is the mechanism by which excess cholesterol from peripheral tissues is transported to the liver for hepatobiliary excretion, thereby inhibiting foam cell formation and the development of atherosclerosis. Exercise affects RCTr, by influencing high-density lipoprotein cholesterol (HDL) through remodeling and by promoting hepatobiliary sterol excretion. The objectives of this systematized review of animal studies is to summarize the literature and provide an overview of the effects of chronic exercise (at least two weeks) on apoliproteins (Apo A-I, Apo-E), Paraoxonase-1 (PON1), ATP-binding cassette transporters (ABCA1, ABCG1, ABCG4, ABCG5, ABCG8), scavenger receptor class B type I (SR-BI), cholesteryl ester transfer protein (CETP), lowdensity lipoprotein receptor (LDLr) and cholesterol 7 alpha-hydroxylase (CYP7A1) and Niemann-Pick C1-like 1 (NPC1L1).

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Euterpe oleracea Mart. (açaí) seed extract associated with exercise training reduces hepatic steatosis in type 2 diabetic male rats

Cited by 22 publications

References 47 publications

Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction

Antidiabetic effect of Euterpe oleracea Mart. (açaí) extract and exercise training on high-fat diet and streptozotocin-induced diabetic rats: A positive interaction

Therapeutic effects of açaí seed extract on hepatic steatosis in high-fat diet-induced obesity in male mice: a comparative effect with rosuvastatin

Effects of exercise on reverse cholesterol transport: A systemized narrative review of animal studies

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