European data sources for computing burden of (potential) vaccine-preventable diseases in ageing adults

Meroc, Estelle; Fröberg, Janeri; Almási, Tímea; Winje, Brita Askeland; Orrico-Sánchez, Alejandro; Steens, Anneke; McDonald, Scott; Bollaerts, Kaatje; Knol, Mirjam J.

doi:10.1186/s12879-021-06017-7

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Surprisingly, non-immunized senescent mice presented higher intestinal secretion of anti-SEBspecific IgA, which would indicate exposure to this microorganism prior to immunization. This could be due to an increased presence of S. aureus in the intestinal microbiota, because dysbiosis associated with aging leads to higher levels of pathogenic and opportunistic microorganisms (30), including S. aureus (31). SDP supplementation did not modify the percentage of B lymphocytes in Peyer's patches, which is consistent with previous results in young rats (32).…”

Section: Discussionsupporting

confidence: 90%

Dietary supplementation with spray-dried animal plasma improves vaccine protection in aged mice

Miró

Rosell-Cardona²,

Amat³

et al. 2023

Front. Nutr.

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BackgroundSenescence is characterized by an aggravated inflammatory state that reduces vaccine responsiveness. Dietary supplementation with spray-dried porcine plasma (SDP) exerts anti-inflammatory effects in different mucosal areas. We aimed to determine if the anti-inflammatory properties of SDP improve the efficiency of immunization in senescent animals.MethodsExperiments were performed in 2-month-old and 6-month-old male SAMP8 mice fed control or SDP (8%) feeds for 4 months. The mice received nasal doses of 2.5 μg of Staphylococcus aureus enterotoxin B (SEB) or vehicle every 15 days (i.e., 3 times). Fifteen days after the last dose, a lethal shock was induced by intraperitoneal administration of SEB and LPS.ResultsImmunization increased anti-SEB IgA in intestinal and bronchoalveolar fluid (p < 0.05). After the lethal shock, all immunized aged mice that were supplemented with SDP survived, in contrast to only 66% of those fed the control feed (p < 0.05). Moreover, after the lethal challenge, aged mice showed higher expression levels of pro-inflammatory cytokines (Il-6, Tnf-α, Ifn-γ, and Il-1β) in jejunal and (Tnf-α, and Il-1β) in lung tissues (p < 0.05), which were reduced by SDP supplementation (p < 0.05). Furthermore, in senescent mice, SDP supplementation augmented Il-4 and Il-10 expression in both tissues (p < 0.05).ConclusionSDP reduces the mucosal inflammation associated with aging, improving vaccine protection in senescent mice.

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Section: Discussionsupporting

confidence: 90%

Dietary supplementation with spray-dried animal plasma improves vaccine protection in aged mice

Miró

Rosell-Cardona²,

Amat³

et al. 2023

Front. Nutr.

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“…The VITAL project has published a review of gaps of data and potential data sources for burden of disease. However, PnPn specific data is lacking for Norway as well as for most European countries [13].…”

Section: Introductionmentioning

confidence: 99%

Estimation of the incidence of hospitalisation for non-invasive pneumococcal pneumonia in the Norwegian population aged 50 years and older

et al. 2022

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The purpose of this study was to estimate simple measures of the burden of non-invasive pneumococcal pneumonia (PnPn) hospitalisations in those aged 50 years and older (50+) in Norway. We conducted a retrospective register-based study and used discharge codes from the Norwegian Patient Register (NPR). We identified episodes of non-invasive PnPn in 2015 to 2016 and predicted its incidence from 2015 to 2019 based on the trend found in notified invasive pneumococcal disease cases. Overall, we identified 45–46 hospital episodes per 100 000 population of non-invasive PnPn in 2015 and 2016, each episode taking 6–8 days, and with increasing incidence with higher age. Among all identified PnPn episodes, 3 out of 4 were classified as non-invasive. We predicted that the monthly number of non-invasive PnPn episodes ranges from 39 [95% confidence interval (CI) 24–55] in August to 97 (95% CI 74–134) in December. No annual trend was identified. This study indicates that the burden of non-invasive PnPn hospitalisation has a substantial impact on the health and health care use of the 50+ population in Norway, despite the childhood immunisation programme. Many hospitalisations may be prevented through vaccination.

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Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain

López-Lacort,

Amini,

Emborg

et al. 2024

The Journal of Infectious Diseases

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Determining pneumococcal pneumonia (PP) burden in the elderly population is challenging due to limited data on invasive PP (IPP) and, in particular, noninvasive PP (NIPP) incidence. Using retrospective cohorts of adults aged ≥50 years in Denmark (2 782 303) and the Valencia region, Spain (2 283 344), we found higher IPP hospitalization rates in Denmark than Valencia (18.3 vs 9/100 000 person-years [PY], respectively). Conversely, NIPP hospitalization rates were higher in Valencia (48.2 vs 7.2/100 000 PY). IPP and NIPP rates increased with age and comorbidities in both regions, with variations by sex and case characteristics (eg, complications, mortality). The burden of PP in adults is substantial, yet its true magnitude remains elusive. Discrepancies in clinical practices impede international comparisons; for instance, Valencia employed a higher frequency of urinary antigen tests compared to Denmark. Additionally, coding practices and prehospital antibiotic utilization may further influence these variations. These findings could guide policymakers and enhance the understanding of international disparities in disease burden assessments.

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European data sources for computing burden of (potential) vaccine-preventable diseases in ageing adults

Cited by 3 publications

References 29 publications

Dietary supplementation with spray-dried animal plasma improves vaccine protection in aged mice

Dietary supplementation with spray-dried animal plasma improves vaccine protection in aged mice

Estimation of the incidence of hospitalisation for non-invasive pneumococcal pneumonia in the Norwegian population aged 50 years and older

Incidence of Invasive and Noninvasive Pneumococcal Pneumonia Hospitalizations in People Aged ≥50 Years: Assessing Variability Across Denmark and Spain

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