Estimation of the incidence of hospitalisation for non-invasive pneumococcal pneumonia in the Norwegian population aged 50 years and older

Abstract

The purpose of this study was to estimate simple measures of the burden of non-invasive pneumococcal pneumonia (PnPn) hospitalisations in those aged 50 years and older (50+) in Norway. We conducted a retrospective register-based study and used discharge codes from the Norwegian Patient Register (NPR). We identified episodes of non-invasive PnPn in 2015 to 2016 and predicted its incidence from 2015 to 2019 based on the trend found in notified invasive pneumococcal disease cases. Overall, we identified 45–46 hospital episodes per 100 000 population of non-invasive PnPn in 2015 and 2016, each episode taking 6–8 days, and with increasing incidence with higher age. Among all identified PnPn episodes, 3 out of 4 were classified as non-invasive. We predicted that the monthly number of non-invasive PnPn episodes ranges from 39 [95% confidence interval (CI) 24–55] in August to 97 (95% CI 74–134) in December. No annual trend was identified. This study indicates that the burden of non-invasive PnPn hospitalisation has a substantial impact on the health and health care use of the 50+ population in Norway, despite the childhood immunisation programme. Many hospitalisations may be prevented through vaccination.

Cost-utility analysis of a universal pneumococcal vaccination programme for older adults in Norway

“…CAP inpatient estimates were based on hospital discharge data from the Norwegian Patient Register (NPR). 18 CAP was defined as a first-listed discharge diagnosis of pneumonia according to the listed ICD10-codes. Episodes per person were defined as one or several admissions for CAP within the same 30 days.…”

“…Episodes per person were defined as one or several admissions for CAP within the same 30 days. Further details and description of the data compilation can be found elsewhere 18 In line with the Swedish study, we assumed that 30% of the cases would be caused by pneumococci. 19 Norwegian CAP data including only noninvasive episodes from 2015 was used to estimate the incidence of PnCAP.…”

Burden of Hospitalizations Related to Pneumococcal Infection in Spain (2016–2020)

“…This is consistent with the data offered by another study in 2015 on the impact of four vaccine-preventable diseases in older adults in Spain [5] and Italy, where, despite reductions in pneumococcal disease-related expenditures following the introduction of PCV13, there continues to be an important economic burden associated with pneumococcal disease [21]. In Norway, a recent study indicated that the burden of noninvasive pneumococcal pneumonia hospitalization had a substantial impact on the health and health care use of the 50+ population in Norway, despite the childhood immunization program [22].…”