This paper presents the numerical and analytical investigations on the distortional buckling of perforated cold-formed steel channel-section beams with circular holes in web. The numerical investigation involves the use of finite element methods. In the analytical analysis the distortional buckling model recommended in EN1993-1-3 is employed. The influence of the web holes on the distortional buckling behaviour and corresponding critical stress and moment of perforated cold-formed steel channel-section beams are discussed. Finally, a simple analytical formulation is proposed for evaluating the effect of hole size on the reduction of critical stress and critical moment of the channel-section beams with circular holes in web.