2019
DOI: 10.1111/ene.13950
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European Academy of Neurology guideline on trigeminal neuralgia

Abstract: Background and purpose Trigeminal neuralgia (TN) is an extremely painful condition which can be difficult to diagnose and treat. In Europe, TN patients are managed by many different specialities. Therefore, there is a great need for comprehensive European guidelines for the management of TN. The European Academy of Neurology asked an expert panel to develop recommendations for a series of questions that are essential for daily clinical management of patients with TN. Methods A systematic review of the literatu… Show more

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Cited by 415 publications
(598 citation statements)
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References 104 publications
(149 reference statements)
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“…80,81 Moreover, for long-term treatment, CBZ and OXC are recommended as the first choice. 79 CBZ blocks VGSCs resulting in inhibition of action potentials, reduction of synaptic transmission, and stabilization of the membrane potential in hyperexcitable neurons. 77,82,83 This effect is achieved in a use-and voltage-dependent manner because CBZ binds to the inactivated channels with higher affinity than to channels in the open or resting state.…”
Section: Studies On Heterologously Expressed Channelsmentioning
confidence: 99%
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“…80,81 Moreover, for long-term treatment, CBZ and OXC are recommended as the first choice. 79 CBZ blocks VGSCs resulting in inhibition of action potentials, reduction of synaptic transmission, and stabilization of the membrane potential in hyperexcitable neurons. 77,82,83 This effect is achieved in a use-and voltage-dependent manner because CBZ binds to the inactivated channels with higher affinity than to channels in the open or resting state.…”
Section: Studies On Heterologously Expressed Channelsmentioning
confidence: 99%
“…126,127 While CBZ and OXC are the first-line drugs recommended for TN, there is not much known about their comparative efficacy in TN. 79 Furthermore, both drugs are associated with frequent and/or severe side effects, but the latter is suggested to have greater tolerability. [128][129][130][131][132][133] A systematic review of the effectiveness and safety of CBZ in different pain conditions concluded that 40% to 60% of the patients would exhibit adverse events, mainly impaired cognition, somnolence, dizziness, gastrointestinal symptoms, headaches, dry mouth or taste change, and mood changes.…”
Section: In Vivo Effectsmentioning
confidence: 99%
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“…Success rate is lower and the recurrence rate higher than those of microvascular decompression [29]. For a treatment algorithm, we further refer to a recently published review article and an even more recent guideline of the European Academy of Neurology [30,31]. PTN is clinically characterized by a more constant burning sensation in the trigeminal area and may be accompanied by sensory changes in this area or even weakness in the masticatory muscles.…”
Section: Neuralgiasmentioning
confidence: 99%