2017
DOI: 10.1016/j.bjp.2016.11.002
|View full text |Cite
|
Sign up to set email alerts
|

Euphorbia umbellata bark extracts – an in vitro cytotoxic study

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
13
0

Year Published

2017
2017
2022
2022

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 13 publications
(13 citation statements)
references
References 39 publications
0
13
0
Order By: Relevance
“…This effect has been observed for the hexane extract of the latex from E. umbellata and other matrices obtained from Euphorbia species, against leukemia cell lineages. [10,12,14,25,26] The cell cycle analysis demonstrated that the treatment with Dcm increased S and G2/M population (compared with the negative control), as observed to doxorubicin ( Figure 4). Similar data already demonstrated the same effect of doxorubicin in HL-60 cell and some lymphoma cell line cycle, showing an increase of S and G2/M phase cell population, which appears to be related with the upregulation of cyclin B1 and cyclin A2, and expression of topoisomerase IIα.…”
Section: Cytotoxic Assaymentioning
confidence: 68%
See 3 more Smart Citations
“…This effect has been observed for the hexane extract of the latex from E. umbellata and other matrices obtained from Euphorbia species, against leukemia cell lineages. [10,12,14,25,26] The cell cycle analysis demonstrated that the treatment with Dcm increased S and G2/M population (compared with the negative control), as observed to doxorubicin ( Figure 4). Similar data already demonstrated the same effect of doxorubicin in HL-60 cell and some lymphoma cell line cycle, showing an increase of S and G2/M phase cell population, which appears to be related with the upregulation of cyclin B1 and cyclin A2, and expression of topoisomerase IIα.…”
Section: Cytotoxic Assaymentioning
confidence: 68%
“…It is already established in literature the influence of terpenes on cytotoxic activity, especially diterpenes, which are present in Dcm and Eth. [15] Intermediate polarity fractions were more cytotoxic to tumoral cells, including leukemia cell lines; [12,22,23] this may be a result of the chemical affinity of terpenes (di-and triterpenes) with such solvents. [15] Therefore, some mechanisms were evaluated for these two fractions against HL-60 lineage cells trying to increase the Figure 3).…”
Section: Cytotoxic Assaymentioning
confidence: 99%
See 2 more Smart Citations
“…6 It is known for its high medicinal value and have strong anti-plasmodial, antibacterial, antifungal activity. 7,8 Extracts of S. glauca have been used for treatment of gastrointestinal disorders. 9 Thus, in order to deeply comprehend, we evaluated S. glauca leaf extract for preliminary phytochemical screening, total phenolic content, and in vitro antioxidant potential was analyzed by ferric ion reducing antioxidant power assay, phosphomolybdenum assay, DPPH assay and in vitro anticancer activity was evaluated on T-24 bladder cancer cells by MTT assay.…”
Section: Introductionmentioning
confidence: 99%