Euphorbetin: a new bicoumarin from L.

Dutta, Prasun; Banerjee, D.; Dutta, N.L.

doi:10.1016/s0040-4039(01)84388-4

Cited by 22 publications

(8 citation statements)

References 13 publications

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“…The overall isolation yield was about 0.25−0.30 g/kg of seeds. An unexpected asset of the KCN method is that precipitation of L 1 ( 2 ) takes place during the transesterification of the ingenol-based L-factors, allowing the recovery of the major L-factor by simple filtration (Scheme ) . A certain selectivity in the hydrolysis step could also be achieved with Zemplén methanolysis under carefully controlled conditions (see Experimental Section).…”

Section: Resultsmentioning

confidence: 99%

An Expeditious Procedure for the Isolation of Ingenol from the Seeds of Euphorbia lathyris

et al. 1998

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Section: Resultsmentioning

confidence: 99%

An Expeditious Procedure for the Isolation of Ingenol from the Seeds of Euphorbia lathyris

et al. 1998

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“…Peaks 42 and 43 were identified as umbelliferone and scopoletin by spiking experiments with authentic standards. Peak 2 with a pseudomolecular ion at m / z 353.02919 was identified as the dicoumarin euphorbetin ( Figure S1b ) [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert

et al. 2018

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Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several constituents of this plant have gastroprotective activity, and particularly, p-coumaroyloxytremetone could be considered as a lead molecule to explore new gastroprotective agents. This plant is a rich source of biologically active tremetones and terpenoids which can support the ethnobotanical use of the plant.

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“…Using co-elution procedures with already identified samples, we were able to identify peaks 10 and 13 as umbelliferone and scopoletin (3). Subject to further confirmation, peak 12 was identified as the dicoumarin euphorbetin because of its parent deprotonated ion at m/z 353.02919 [35,36]…”

Section: Coumarinsmentioning

confidence: 99%

Polyphenolic Composition and Hypotensive Effects of Parastrephia quadrangularis (Meyen) Cabrera in Rat

et al. 2019

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Parastrephia quadrangularis (Pq), commonly called “Tola”, is widely used in folk medicine in the Andes, including for altitude sickness. In this study, polyphenolic composition was determined, and hypotensive effects were measured; the ethnopharmacological use as hypotensive was related to the presence of phenolic compounds. For this purpose, male Sprague-Dawley rats (6 to 8 weeks of age, 160 to 190 g) were fed Pq extract (10 to 40 mg/kg) for 10 days through gavage. Blood pressures and heart rate were significantly (p < 0.01) reduced in normotensive rats receiving Pq extract (40 mg/kg body weight). Pq extract induced a negative inotropic effect, and endothelium-dependent vasodilation mediated by nitric oxide (NO). Furthermore, preincubation with Pq extract significantly decreased the cytosolic calcium on vascular smooth muscle cells A7r5 in response to L-phenylephrine (PE). Seven metabolites were isolated from the Pq extract, but three flavonoids (10−4 M) showed similar vasodilation to the extract in intact rat aorta as follows: 5,3′,4′-trihydroxy-7-methoxyflavanone (2); 3,5,4′-trihydroxy-7,8,3′-trimethoxyflavone (6); and 5,4′-dihydroxy-3,7,8,3′-tetramethoxyflavone (7). The Pq extract and compounds 2 and 7 significantly (p < 0.05) reduced the contraction to Bay K8644 (10 nM, an agonist of CaV1.2 channels). Administration of Pq decreased cardiac contractility and increased endothelium-dependent and -independent vasodilation.

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Euphorbetin: a new bicoumarin from L.

Cited by 22 publications

References 13 publications

An Expeditious Procedure for the Isolation of Ingenol from the Seeds of Euphorbia lathyris

An Expeditious Procedure for the Isolation of Ingenol from the Seeds of Euphorbia lathyris

Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert

Polyphenolic Composition and Hypotensive Effects of Parastrephia quadrangularis (Meyen) Cabrera in Rat

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