Eudesmane derivatives from pluchea odorata

Arriaga-Giner, F. J.; Borges-del-Castillo, J.; Manresa-Ferrero, M.T.; Vázquez-Bueno, P.; Rodríguez-Luis, Francisco; Valdés-Iraheta, S.

doi:10.1016/s0031-9422(00)80267-8

Cited by 35 publications

(17 citation statements)

References 4 publications

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“…It was shown that it contains flavonoids, triterpenes (28,29), phytosterols (44), and Plucheinol, an eudesmane type sesquiterpene unique to P. odorata (30,31). A comparison between two P. odorata populations from Mexico and El Salvador showed that the Mexican population contained a greater number of triterpenes and flavonoids, whereas the plants from El Salvador contained a greater number of sesquiterpenes (29,45). Whether the different P. odorata populations also exhibit different anti-cancer activity needs to be established and could elucidate which type(s) of the plant constituents may be responsible for the here described effects.…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-cancer activity of two ethno-pharmacological healing plants from Guatemala Pluchea odorata and Phlebodium decumanum

Gridling

Stark²,

Madlener³

et al. 2009

Int J Oncol

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Abstract. Many traditional healing plants successfully passed several hundred years of empirical testing against specific diseases and thereby demonstrating that they are well tolerated in humans. Although quite a few ethnopharmacological plants are applied against a variety of conditions there are still numerous plants that have not been cross-tested in diseases apart from the traditional applications. Herein we demonstrate the anti-neoplastic potential of two healing plants used by the Maya of the Guatemala/Belize area against severe inflammatory conditions such as neuritis, rheumatism, arthritis, coughs, bruises and tumours. Phlebodium decumanum and Pluchea odorata were collected, dried and freeze dried, and extracted with five solvents of increasing polarity. We tested HL-60 and MCF-7 cells, the inhibition of proliferation and the induction of cell death were investigated as hallmark endpoints to measure the efficiency of anti-cancer drugs. Western blot and FACS analyses elucidated the underlying mechanisms. While extracts of P. decumanum showed only moderate anti-cancer activity and were therefore not further analysed, particularly the dichloromethane extract of P. odorata inhibited the cell cycle in G2-M which correlated with the activation of checkpoint kinase 2, and down-regulation of Cdc25A and cyclin D1 as well as inactivation of Erk1/2. In HL-60 and MCF-7 cells this extract was a very strong inducer of cell death activating caspase-3 followed by PARP signature type cleavage. The initiating death trigger was likely the stabilization of microtubules monitored by the rapid acetylation of ·-tubulin, which was even more pronounced than that triggered by taxol. The dichloromethane extract of P. odorata contains apolar constituents which inhibit inflammatory responses and exhibit anti-cancer activity. The strong proapoptotic potential warrants further bioassay-guided fractionation to discover and test the active principle(s).

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Section: Discussionmentioning

confidence: 99%

In vitro anti-cancer activity of two ethno-pharmacological healing plants from Guatemala Pluchea odorata and Phlebodium decumanum

Gridling

Stark²,

Madlener³

et al. 2009

Int J Oncol

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“…(200 ≤ MIC 100 ≤ 400 mg/ml), and the hexanic extract of P. carolinensis showed a low anti-Pneumocystis activity (MIC 100 = 100 mg/ml). The identification of some sesquiterpenes (eudesmane and cuathemone structure), phenolic compounds (flavonols, phenolic acids) and triterpenes has been reported (Ahmed et al, 1998;Arriaga and Borges-Del-Castillo, 1983;Arriaga and Borges-Del-Castillo, 1985;Dominguez and Zamudio, 1972;Gupta, 1995;Perera et al, 2007 ;Perera Córdova et al, 2010;Wollenweber et al, 1985).…”

Section: Resultsmentioning

confidence: 99%

Antifungal Activity of 10 Guadeloupean Plants

Biabiany

Roumy

Hennebelle

et al. 2012

Phytotherapy Research

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Screening of the antifungal activities of ten Guadeloupean plants was undertaken to find new extracts and formulations against superficial mycoses such as onychomycosis, athlete's foot, Pityriasis versicolor, as well as the deep fungal infection Pneumocystis pneumonia. For the first time, the CMI of these plant extracts [cyclohexane, ethanol and ethanol/water (1:1, v/v)] was determined against five dermatophytes, five Candida species, Scytalidium dimidiatum, a Malassezia sp. strain and Pneumocystis carinii. Cytotoxicity tests of the most active extracts were also performed on an HaCat keratinocyte cell line. Results suggest that the extracts of Bursera simaruba, Cedrela odorata, Enterolobium cyclocarpum and Pluchea carolinensis have interesting activities and could be good candidates for developing antifungal formulations.

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“…The CH 2 Cl 2 extract exhibited antimalarial activity (IC 50 = 3.6 g/ml), which was considered promissory according present endpoint criteria for medicinal plants extracts (Huber and Koella, 1993;Soh and Benoit-Vical, 2007). After several separation steps, the most bioactive fractions were deeper studied until yielding seven pure metabolites which were identified as eudesmin (1) (Latip et al, 1999), magnolin (2) (Seo, 2010), epimagnolin A (3) (Seo, 2010), aschantin (4) (Ahmed et al, 2002), kobusin (5) (Latip et al, 1999), sesamin (6) (Kuropka and Glombitza, 1987) and artemetin (7) (Arriaga-Giner et al, 1983), respectively based on spectroscopic analyses and comparison with reported NMR data (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%