Etudes sur la pigmentation

Robert, P; H, Zurcher; Schmidli, B.

doi:10.1159/000256846

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Iron and Alterations In Cutaneous Pigmentation1

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2000

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Cited by 11 publications

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“…Generalized metallic grey or brown cutaneous pigmentation, which is more pronounced in sun-exposed areas, occurs in approximately 90% of affected persons. The exact cause of the hyperpigmentation is controversial, though likely due to both the presence of iron deposits and increased melanogenesis that may be triggered by iron, acting as a catalyst [5]. Other causes of systemic iron overload are generally less severe and are referred to as secondary iron overload.…”

Section: Iron and Alterations In Cutaneous Pigmentationmentioning

confidence: 99%

Role of Iron in Dermatology

Simonart

Vooren²,

Parent³

et al. 2000

Dermatology

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Iron is involved in several biological reactions and is essential to almost all forms of life. In contrast, iron is potentially toxic. It may participate in many dermatological disorders, including pigmentation changes, inflammation, porphyrias, infections and cancers. The involvement of iron in these disorders entails a variety of mechanisms, including among others simple deposition processes, activation or inactivation of enzymatic systems, impairment of phagocyte functions and interference with apoptosis. A better understanding of the role of iron might provide novel therapeutic strategies based on iron-chelating and/or anti-oxidant agents.

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Section: Iron and Alterations In Cutaneous Pigmentationmentioning

confidence: 99%