Etlingera pavieana extract attenuates TNF-α induced vascular adhesion molecule expression in human endothelial cells through NF-κB and Akt/JNK pathways

Acute and subchronic oral toxicity assessment of extract from Etlingera pavieana rhizomes

“…This is the first report of the acute and subchronic toxicity of E. pavieana rhizome extract (EPE) in rats. To date, evidence pertaining to toxicity of this extract or its potential active constituents has been reported in several different cell lines including mouse macrophages [10] , [12] , [14] , mouse microglia [21] , and human endothelial cells [11] , [13] . One of the bioactive compounds in E. pavieana rhizomes, MCC, has been evaluated in acute oral toxicity study in mice, and found to be nontoxic after acute exposure [15] .…”

“…E. pavieana rhizomes are widely used in traditional medicine and consumed as food [7] , [8] . Several pharmacological studies of E. pavieana have been reported [10] , [11] , [13] , [17] , [21] . In this study, the highest dose of EPE was set at 2,000 mg/kg for both acute and subchronic toxicity tests, since E. pavieana rhizome is commonly used as food and a dose limit in traditional medicine has not yet been established.…”

“…Phytochemical studies of E. pavieana have identified several phenylpropanoids and the major components, trans -4-methoxycinnamaldehyde (MCD) and 4-methoxycinnamyl p-coumarate (MCC) [9] , [10] , possess several pharmacological activities, including antioxidant [11] , anti-inflammatory [10] , [11] , [12] , [13] , [14] , [15] , antimicrobial [16] , and anticancer [17] effects. Moreover, the single oral administration of MCC at a dose of 2,000 mg/kg body weight did not produce any acute toxic effects or mortality in mice, indicating the relative safety of this bioactive compound from E. pavieana rhizomes [15] .…”

Pharmacological Activities and Phytochemicals of Etlingera pavieana (Pierre ex Gagnep) R.M.Sm

“…Moreover, Akt activation by E. pavieana rhizome is associated with negative regulation of inflammation. This anti-vascular inflammatory activity was attributed in part due to the presence of the two most active phenolic compounds of which were 4-methoxycinnamyl p-coumarate and trans-4-methoxycinnamaldehyde [50].…”

Anti-oral streptococci and anti-biofilm properties of Etlingera pavieana essential oil and its bioactive compounds proposed for an alternative herbal mouthwash

“…In folk medicine, E. pavieana rhizome has been used as anti-pyretic, anti-flatulence, anti-emetic, and diuretics in southeastern Thailand and Cambodia. Previous studies showed the pharmacological activity of E. pavieana rhizome including antibacterial, anticancer, antioxidant, anti-inflammation, and anti-atherosclerosis [ [1] , [2] , [3] , [4] , [5] ]. Chemotaxonomic studies revealed that E. pavieana was grouped to species containing mainly phenylpropanoids.…”