Etiopathogenetic methods of treating patients with chronic inflammatory-destructive periodontal diseases

Abstract

This article presents the etiopathogenetic-based methods of treating patients with chronic generalized inflammatory-destructive periodontal diseases periodontitis, which are mostly multicomponent and are performed in stages. The comprehensive therapy of inflammatory-destructive periodontal diseases should include the identification of common and local endogenous and exogenous parodontopathogenic factors and disease predictors, with the aim of normalizing the microbioprofile in periodontal pockets, providing osteoregeneratory, biostimulating, and normalizing effects on the microhemocirculation, relying on the achievements of genetics and epigenetics, personalized, and meet the requirements of evidence.

Pharmacocorrection of Disturbances in the no System in Experimental Chronic Generalized Periodontitis

“…According to the WHO in 2016, periodontal diseases, which lead to tooth loss, became the 11 th most important among the spread of diseases on the planet [1]. In the light of modern views on the pathogenesis of inflammatory diseases of the oral cavity, a promising direction is the use of agents with metabolitotropic, endothelioprotective, and especially with an antioxidant action (Mexidol, selenites, α-tocopherol, propolis preparations, and SODrec) [2], [3], [4]. Recently, it has been established that an important link in the pathogenesis of inflammatory processes in the oral mucosa is the expression of proinflammatory cytokines -IL-1b, TNF-a, an increase in iNOS activity and activation of nitrosative stress, accompanied by an increase in cytotoxic forms of NO.…”