Etiopathogenesis of ovarian cancer. An inflamm-aging entity?

Sánchez‐Prieto, Manuel; Sánchez-Borrego, Rafael; Lubián-López, Daniel Maria; Pérez‐López, Faustino R.

doi:10.1016/j.gore.2022.101018

Cited by 11 publications

(11 citation statements)

References 63 publications

(83 reference statements)

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“… 35 , 58 , 59 , 60 This microenvironment has potential ramifications for pathologies such as ovarian cancer. 61 , 62 , 63 To our knowledge, this is the first report showing the effect of CD38 genetic ablation in shaping the immune landscape during aging.…”

Section: Discussionmentioning

confidence: 78%

CD38 regulates ovarian function and fecundity via NAD+ metabolism

Perrone,

Ashok Kumaar,

Haky

et al. 2023

iScience

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Section: Discussionmentioning

confidence: 78%

CD38 regulates ovarian function and fecundity via NAD+ metabolism

Perrone,

Ashok Kumaar,

Haky

et al. 2023

iScience

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“…This observation is particularly relevant given that ovarian aging, as a result of continuous follicle atresia and clearance as well as repeated cycles of ovulation-associated inflammation, wound repair and remodeling, is associated with increased ovarian inflammation, fibrosis, and stiffness 35,[56][57][58] . This microenvironment has potential ramifications for pathologies such as ovarian cancer 59,60,61 . To our knowledge, this is the first report showing the effect of CD38 genetic ablation in shaping the immune landscape during aging.…”

Section: Discussionmentioning

confidence: 99%

CD38 regulates ovarian function and fecundity via NAD⁺metabolism

Perrone,

Ashok Kumaar,

Haky

et al. 2023

Preprint

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SummaryMammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, a NAD+ consuming enzyme, is expressed in the ovarian extrafollicular space, primarily in immune cells, and its levels increase with reproductive age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated ovarian NAD+ levels, and increased fecundity relative to wild type controls. This larger ovarian reserve results from a prolonged window of follicle formation during early development. However, the beneficial effect of CD38 loss on reproductive function is not maintained at advanced age. Our results demonstrate a novel role of CD38 in regulating ovarian NAD+ metabolism and establishing the ovarian reserve, a critical process that dictates a female’s reproductive lifespan.

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“…Chronic low-grade inflammation is considered as one of the etiologic factors contributing to survival of neoplastic growth and malignancy in ovarian cancer 17 , 18 . In a previous study, women having higher serum levels of BDNF, PDGFAA and PDGFABBB, had improved PFS 19 .…”

Section: Discussionmentioning

confidence: 99%

Ovarian recurrence risk assessment using machine learning, clinical information, and serum protein levels to predict survival in high grade ovarian cancer

Mysona,

Purohit,

Richardson

et al. 2023

Sci Rep

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In ovarian cancer, there is no current method to accurately predict recurrence after a complete response to chemotherapy. Here, we develop a machine learning risk score using serum proteomics for the prediction of early recurrence of ovarian cancer after initial treatment. The developed risk score was validated in an independent cohort with serum collected prospectively during the remission period. In the discovery cohort, patients scored as low-risk had a median time to recurrence (TTR) that was not reached at 10 years compared to 10.5 months (HR 4.66, p < 0.001) in high-risk patients. In the validation cohort, low-risk patients had a median TTR which was not reached compared to 4.7 months in high-risk patients (HR 4.67, p = 0.009). In advanced-stage patients with a CA125 < 10, low-risk patients had a median TTR of 68 months compared to 6 months in high-risk patients (HR 2.91, p = 0.02). The developed risk score was capable of distinguishing the duration of remission in ovarian cancer patients. This score may help guide maintenance therapy and develop innovative treatments in patients at risk at high-risk of recurrence.

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Etiopathogenesis of ovarian cancer. An inflamm-aging entity?

Cited by 11 publications

References 63 publications

CD38 regulates ovarian function and fecundity via NAD+ metabolism

CD38 regulates ovarian function and fecundity via NAD+ metabolism

CD38 regulates ovarian function and fecundity via NAD⁺metabolism

Ovarian recurrence risk assessment using machine learning, clinical information, and serum protein levels to predict survival in high grade ovarian cancer

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Etiopathogenesis of ovarian cancer. An inflamm-aging entity?

Cited by 11 publications

References 63 publications

CD38 regulates ovarian function and fecundity via NAD+ metabolism

CD38 regulates ovarian function and fecundity via NAD+ metabolism

CD38 regulates ovarian function and fecundity via NAD+metabolism

Ovarian recurrence risk assessment using machine learning, clinical information, and serum protein levels to predict survival in high grade ovarian cancer

Contact Info

Product

Resources

About

CD38 regulates ovarian function and fecundity via NAD⁺metabolism